Gold Nanoparticles and Chemotherapeutic Agents

Avram, Alexandra; Tomoaia, Gheorghe; Mocanu, Aurora; Tomoaia-Cotişel, Maria

doi:10.56082/annalsarsciphyschem.2020.2.23

“…An addition of some secondary nanoparticles such as gold nanoparticles (GNPs, AuNPs) [130][131][132][133][134][135][136][137][138][139][140][141][142][143][144][145] could also be of interest due to their outstanding surface functionalization chemistry that allows them to be functionalized with almost all electron-donating molecules [146]. Moreover, different formulations of GNPs have been proven as quite efficacious against some pathogenic strains such as E. coli, S. aureus, B. subtilis, K. pneumoniae, C. albicans or P. aeruginosa [147][148][149].…”

Section: Future Trendsmentioning

confidence: 99%

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2022

AnnalsARSciPhysChem

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Synthetic hydroxyapatite (Ca10(PO4)6(OH)2, HAP) is widely used in regards to orthopedic applications due to its similarity to the mineral component in bone. However, while HAP aids with osseointegration it does nothing when it comes to orthopedic infections. Moreover, the prevalence of antibiotic resistance makes treatment even more difficult. In view of this, adding silver to hydroxyapatite has been a focus of many studies due to the combined bioactivity of HAP and excellent antibacterial properties of Ag. The present work brings a brief introduction to more recent studies regarding the HAP-silver combination and its effect on different pathogenic strains. The effect of silver on benign cells is also discussed based on in vitro cultures and in vivo studies.

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“…An addition of some secondary nanoparticles such as gold nanoparticles (GNPs, AuNPs) [130][131][132][133][134][135][136][137][138][139][140][141][142][143][144][145] could also be of interest due to their outstanding surface functionalization chemistry that allows them to be functionalized with almost all electron-donating molecules [146]. Moreover, different formulations of GNPs have been proven as quite efficacious against some pathogenic strains such as E. coli, S. aureus, B. subtilis, K. pneumoniae, C. albicans or P. aeruginosa [147][148][149].…”

Section: Future Trendsmentioning

confidence: 99%

Antibacterial Effect of Hydroxyapatite and Silver

Avram¹,

Mocanu²,

Horovitz³

et al. 2022

AnnalsARSciPhysChem

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Synthetic hydroxyapatite (Ca10(PO4)6(OH)2, HAP) is widely used in regards to orthopedic applications due to its similarity to the mineral component in bone. However, while HAP aids with osseointegration it does nothing when it comes to orthopedic infections. Moreover, the prevalence of antibiotic resistance makes treatment even more difficult. In view of this, adding silver to hydroxyapatite has been a focus of many studies due to the combined bioactivity of HAP and excellent antibacterial properties of Ag. The present work brings a brief introduction to more recent studies regarding the HAP-silver combination and its effect on different pathogenic strains. The effect of silver on benign cells is also discussed based on in vitro cultures and in vivo studies.

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“…Another study niche could be the functionalization of forsterite with different metallic nanoparticles [113][114][115][116][117][118][119][120][121][122][123][124][125][126][127][128][129][130][131] and biologically active molecules, which improve upon forsterite properties.…”

Section: Future Trendsmentioning

confidence: 99%

Forsterite as an Alternative for Orthopaedic Implants – Short Review

Avram¹,

Mocanu²,

Tomoaia³

et al. 2021

AnnalsARSciPhysChem

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The research to find an ideal bone substitute material is still ongoing. The majority of research is focused on calcium phosphates and predominantly on hydroxyapatite. However, forsterite, a magnesium silicate (FS, Mg2SiO4), has recently received a large attention in regards to biomedical applications due to its high bioactivity. Its superior mechanical properties also recommend it for load-bearing applications. This work focusses on the significance of the properties of FS as a promising candidate for bone substitutions.

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Gold Nanoparticles and Chemotherapeutic Agents

Cited by 6 publications

References 178 publications

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Antibacterial Effect of Hydroxyapatite and Silver

Forsterite as an Alternative for Orthopaedic Implants – Short Review

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