Gold nanoparticles as a contrast agent for<i>in vivo</i>tumor imaging with photoacoustic tomography

Zhang, Q.; Iwakuma, Nobutaka; Sharma, Prashant; Moudgil, Brij M.; Wu, Changfeng; McNeill, Jason; Jiang, Huabei; Grobmyer, Stephen R.

doi:10.1088/0957-4484/20/39/395102

Cited by 227 publications

(111 citation statements)

References 31 publications

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“…In addition to their biocompatibility, Au nanoparticles have longer in vivo circulation times during the imaging process and in some cases faster elimination time post-procedure [356,[363][364][365]. Additionally, since the atomic number of Au is higher than that of iodine, Au nanostructures have higher absorption efficiencies which means that in vivo contrast will be enhanced [35,356,364,366].…”

Section: Imagingmentioning

confidence: 99%

Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

2016

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By electrodeposition and galvanic replacement reaction, we developed a facile, time-saving, cost-effective, and environmentally friendly, two-step synthesis route to obtain a controllable cobalt oxide/Au hierarchically nanostructured electrode for glucose sensing. The nanomaterials were characterized by transmission electron microscopy, scanning electron microscopy, Raman spectroscopy, energy-dispersive spectrometry, and X-ray photoelectron spectroscopy, meanwhile, the sensing performance was investigated by cyclic voltammetry and amperometric response. The results revealed that this novel electrode exhibited excellent electrocatalytic performance toward glucose oxidation, with a wide double-linear range from 0.2 μM to 20 mM and a low detection limit of 0.1 μM based on a signal-to-noise ratio of 3, which was mainly attributed to the ability of loading a small amount of Au with good electron conductivity on the surface of cobalt oxide nanosheets with large active surface area and synergistic electrocatalytic activity of Au and cobalt oxide toward glucose electrooxidation. This facile, sensitive, and selective glucose sensor is also proven to be suitable for the detection of glucose in human serum.

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Section: Imagingmentioning

confidence: 99%

Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

2016

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“…Macrophages are known as 'big eaters', that phagocytose nanomaterials like GNP with high rate [86]. The GNP have long been used in the detection and imaging of biological processes and diseases [46,47,61,62,70,87]. The broad range of GNP applications is based on their unique chemical and physical properties and, in particular, on their optical properties from the visible to the IR region, depending on the particle size, shape, and structure [88,89].…”

Section: Magnetic Particlesmentioning

confidence: 99%

Nanoparticle uptake by macrophages in vulnerable plaques for atherosclerosis diagnosis

Melzer

Ankri

Fixler

et al. 2015

Journal of Biophotonics

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The composition of atherosclerotic (AS) plaques is crucial concerning rupture, thrombosis and clinical events. Two plaque types are distinguished: stable and vulnerable plaques. Vulnerable plaques are rich in inflammatory cells, mostly only M1 macrophages, and are highly susceptible to rupture. These plaques represent a high risk particularly with the standard invasive diagnosis by coronary angiography. So far there are no non‐invasive low‐risk clinical approaches available to detect and distinguish AS plaque types in vivo. The perspective review introduces a whole work‐flow for a novel approach for non‐invasive detection and classification of AS plaques using the diffusion reflection method with gold nanoparticle loaded macrophages in combination with flow and image cytometric analysis for quality assurance. Classical biophotonic methods for AS diagnosis are summarized. Phenotyping of monocytes and macrophages are discussed for specific subset labelling by nanomaterials, as well as existing studies and first experimental proofs of concept for the novel approach are shown.

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“…PAI has the advantages of high optical contrast and good ultrasound penetration, and can provide multidimensional tumor data, including structural, functional, metabolic, and molecular information 7. To date, most work has been focused on solid tumor detection at the macroscopic level 7, 8, 9, 10, 11, 12, 13, 14, 15, 16. However, solid tumor usually evolves from a single cell 17.…”

Section: Introductionmentioning

confidence: 99%

“…AuNPs have already been used in PAI to image and diagnose a variety of cancers,7, 9, 10, 11, 12, 13, 14, 15, 16 such as melanoma,9 squamous cell carcinoma,10 prostate cancer,11 colon carcinoma,12 breast cancer,13 and circulating tumor cells 14, 15, 16. Several parameters, such as size, shape, and surface chemistry, are critical for their photoacoustic applications 34.…”

Section: Introductionmentioning

confidence: 99%

Plasmonic Nanoparticles with Quantitatively Controlled Bioconjugation for Photoacoustic Imaging of Live Cancer Cells

Tian

Qian²,

Shao

et al. 2016

Advanced Science

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Detection and imaging of single cancer cells is critical for cancer diagnosis and understanding of cellular dynamics. Photoacoustic imaging (PAI) provides a potential tool for the study of cancer cell dynamics, but faces the challenge that most cancer cells lack sufficient endogenous contrast. Here, a type of colloidal gold nanoparticles (AuNPs) are physically fabricated and are precisely functionalized with quantitative amounts of functional ligands (i.e., polyethyleneglycol (PEG) and (Arginine(R)–Glycine(G)–Aspartic(D))4 (RGD) peptides) to serve as an exogenous contrast agent for PAI of single cells. The functionalized AuNPs, with a fixed number of PEG but different RGD densities, are delivered into human prostate cancer cells. Radioactivity and photoacoustic analyses show that, although cellular uptake efficiency of the AuNPs linearly increases along with RGD density, photoacoustic signal generation efficiency does not and only maximize at a moderate RGD density. The functionalization of the AuNPs is in turn optimized based on the experimental finding, and single cancer cells are imaged using a custom photoacoustic microscopy with high‐resolution. The quantitatively functionalized AuNPs together with the high‐resolution PAI system provide a unique platform for the detection and imaging of single cancer cells, and may impact not only basic science but also clinical diagnostics on a range of cancers.

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Gold nanoparticles as a contrast agent forin vivotumor imaging with photoacoustic tomography

Cited by 227 publications

References 31 publications

Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

Nanoparticle uptake by macrophages in vulnerable plaques for atherosclerosis diagnosis

Plasmonic Nanoparticles with Quantitatively Controlled Bioconjugation for Photoacoustic Imaging of Live Cancer Cells

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