2023
DOI: 10.3390/mi14020451
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Gold Nanoparticles as Drug Carriers: The Role of Silica and PEG as Surface Coatings in Optimizing Drug Loading

Abstract: The use of gold nanoparticles as drug delivery systems has received increasing attention due to their unique properties, such as their high stability and biocompatibility. However, gold nanoparticles have a high affinity for proteins, which can result in their rapid clearance from the body and limited drug loading capabilities. To address these limitations, we coated the gold nanoparticles with silica and PEG, which are known to improve the stability of nanoparticles. The synthesis of the nanoparticles was car… Show more

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Cited by 8 publications
(3 citation statements)
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“…It can be functionalised by attaching a range of ligands, biological molecules, or polymers to the nanoparticle surface. Gold nanoparticles (AuNPs) have multiple applications as a drug carrier, imaging probe, catalyst, or sensor material [12][13][14]. Nanogold specifically exhibits amplified surface activity, chemical reactivity, and modified optical properties compared to larger gold particles [15].…”
Section: Introductionmentioning
confidence: 99%
“…It can be functionalised by attaching a range of ligands, biological molecules, or polymers to the nanoparticle surface. Gold nanoparticles (AuNPs) have multiple applications as a drug carrier, imaging probe, catalyst, or sensor material [12][13][14]. Nanogold specifically exhibits amplified surface activity, chemical reactivity, and modified optical properties compared to larger gold particles [15].…”
Section: Introductionmentioning
confidence: 99%
“…While current standard treatments are effective in treating malignant gliomas, it remains unsettling to improve the effectiveness of these tried-and-true methods. In addition to integrating the development of innovative drug delivery techniques, tools, and materials, some recent researcheshave resolved numerous issues related to drug delivery towards malignant gliomas [57].…”
Section: Aunps In Drug Deliverymentioning
confidence: 99%
“…Some stabilizers are also added to tailor the size of the nanoparticles (Nguyen and Bruce 2014). González et al (2023) discovered that gold nanoparticles had a strong affinity for proteins, resulting in quick clearance from the body and restricted drug-loading capacities. To overcome these constraints, they coated the gold nanoparticles with silica and PEG to improve nanoparticle stability.…”
Section: Introductionmentioning
confidence: 99%