Gold nanoparticles assisted colorimetric sensing of paroxetine, duloxetine, and olanzapine in aqueous and micellar systems with improved sensitivity

Laghari, Sana; Khuhawar, Muhammad Yar; Jahangir, Taj Muhammad; Jamil, Waqas

doi:10.1016/j.microc.2024.110749

Microchemical Journal

2024

DOI: 10.1016/j.microc.2024.110749

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Gold nanoparticles assisted colorimetric sensing of paroxetine, duloxetine, and olanzapine in aqueous and micellar systems with improved sensitivity

Sana Laghari,

Muhammad Yar Khuhawar,

Taj Muhammad Jahangir

et al.

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2024

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Cited by 1 publication

References 43 publications

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Anti-fibrillation Effect of Gold Nanoparticles Conjugated with Boswellic Acid on α-synuclein

Gharb,

Mozafari,

Arghavani

et al. 2024

Preprint

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Neurodegenerative diseases such as Alzheimer’s and Parkinson’s are characterized by the death of neurons in specific brains. α-synuclein (α-Syn) is a key factor in Parkinson’s disease (PD), forming toxic fibrils when misfolded. Natural products, such as Boswellia serrata, have shown promise in treating neurodegenerative diseases. However, the poor pharmacological performance of Boswellia acids (BAs) limits their effectiveness. Enhancing the bioavailability of BAs through nanocarriers could be a solution. This study explores the potential of β-Boswellic acid conjugated to gold nanoparticles (GNPs) as a novel PD treatment. Covalent and noncovalent conjugations of β-Boswellic acid to GNPs (GNP-BA) were developed to study their impact on α-Syn fibrillation in vitro. The successful synthesis of spherical GNPs (< 32 nm) was confirmed using high-resolution transmission electron microscopy (HR-TEM) and field emission scanning electron microscopy (FESEM). UV-visible and Fourier-transform infrared (FTIR) spectroscopies confirmed the conjugation of BA to GNPs. Specific interactions between α-Syn and GNP-BA conjugates were observed, with GNPs noncovalently bound to BA effectively inhibiting fibril formation. Thioflavin T (ThT) assay and atomic force microscopy (AFM) further supported the inhibitory effect of designed GNPs on α-Syn fibrillation, suggesting a potential therapeutic approach for PD treatment.

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Anti-fibrillation Effect of Gold Nanoparticles Conjugated with Boswellic Acid on α-synuclein

Gharb,

Mozafari,

Arghavani

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

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Gold nanoparticles assisted colorimetric sensing of paroxetine, duloxetine, and olanzapine in aqueous and micellar systems with improved sensitivity

Cited by 1 publication

References 43 publications

Anti-fibrillation Effect of Gold Nanoparticles Conjugated with Boswellic Acid on α-synuclein

Anti-fibrillation Effect of Gold Nanoparticles Conjugated with Boswellic Acid on α-synuclein

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