Gold nanoparticles attenuate LPS-induced NO production through the inhibition of NF-κB and IFN-β/STAT1 pathways in RAW264.7 cells

Su, Ji Guo; Kim, Wan Jae; Kim, Jae Jin; Kim, Tack Joong; Ye, Sang Kyu; Song, Min Dong; Kang, Hunseung; Kim, Dong Woo; Moon, Won Kook

doi:10.1016/j.niox.2010.06.005

Cited by 96 publications

(75 citation statements)

References 39 publications

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“…12,24) Since overproduction of NO leads to a variety of diseases, including atherosclerosis, malignancy, rheumatoid arthritis, tissue injuries, and septic shock, 12,[25][26][27] downregulation of NO is very important for the regulation of these diseases. In the present study, we examined the anti-inflammatory activity and mechanism of action of the AGF extract in macrophages, and found that AGF decreased LPSinduced NO production in RAW 264.7 cells (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Previous reports have indicated that LPS-induced activation of MAPKs upregulated the production of pro-inflammatory cytokines (IL-6 and IL-1) and iNOS expression. 12,31,32) Also, recent studies have found that activation of the PI3K/Akt signal pathway leads to activation of NF-B through degradation of IB. LPS-induced activation of NF-B regulates the expression of a variety of inflammatory genes, such as inflammatory cytokines and iNOS, in macrophages.…”

Section: Discussionmentioning

confidence: 99%

“…NO has a range of biological functions, including host defense, neurotransmission, neurotoxicity, and vasodilation. 12) It is synthesized by nitric oxide synthase (NOS) enzymes, which are classified into three isoforms. The endothelial NOS (eNOS) and neuronal NOS (nNOS) isoforms are constitutively present.…”

mentioning

confidence: 99%

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<i>Anethum graveloens</i> Flower Extracts Inhibited a Lipopolysaccharide-Induced Inflammatory Response by Blocking iNOS Expression and NF-κB Activity in Macrophages

Kim

Shin

Kim

2012

Bioscience, Biotechnology, and Biochemistry

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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<i>Anethum graveloens</i> Flower Extracts Inhibited a Lipopolysaccharide-Induced Inflammatory Response by Blocking iNOS Expression and NF-κB Activity in Macrophages

Kim

Shin

Kim

2012

Bioscience, Biotechnology, and Biochemistry

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“…For example, they inhibit production of reactive nitrogen [36] and oxygen [37] species, as well as activation of NF-κB [36]. In addition, Au NPs do not induce secretion of the proinflammatory cytokines TNF-α and IL-1β [37].…”

Section: Introductionmentioning

confidence: 99%

An investigation into the interactions of gold nanoparticles and anti-arthritic drugs with macrophages, and their reactivity towards thioredoxin reductase

James

Sluyter

et al. 2015

Journal of Inorganic Biochemistry

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“…Furthermore, GNPs suppressed the LPSinduced activation of NF-kB through the inhibition of Akt activity. GNPs also inhibited the LPS-induced phosphorylation of signal transducer and activator of transcription-1 via the down-regulation of interferon-b expression (Ma et al, 2010).…”

Section: Discussionmentioning

confidence: 95%

Effects of phonophoresis with gold nanoparticles on oxidative stress parameters in a traumatic muscle injury model

et al. 2014

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The aim of this study was to evaluate the effects of therapeutic pulsed ultrasound with gold nanoparticles on oxidative stress parameters after traumatic muscle injury in Wistar rats. The animals were randomly divided into nine groups (n ¼ 6 each): sham (uninjured muscle); muscle injury without treatment; muscle injury and treatment with dimethyl sulfoxide (15 mg/kg); muscle injury and treatment with gold nanoparticles (27 mg); muscle injury and treatment with dimethyl sulfoxide + gold nanoparticles (Plus); muscle injury and therapeutic pulsed ultrasound; muscle injury and therapeutic pulsed ultrasound + dimethyl sulfoxide; muscle injury and therapeutic pulsed ultrasound + gold nanoparticles; and muscle injury and therapeutic pulsed ultrasound + Plus. Gastrocnemius injury was induced by a single-impact blunt trauma. Therapeutic pulsed ultrasound (6-min application, frequency 1.0 MHz, intensity 0.8 W/cm 2 ) was used 2, 12, 24, and 48 h after trauma. Mitochondrial superoxide generation, lipid peroxidation, and protein carbonylation, and the activities of superoxide dismutase, glutathione peroxidase, and catalase were evaluated. The increase in the superoxide production and TBARS and carbonyl levels observed in the control group after muscle damage were reduced in animals exposed to therapeutic pulsed ultrasound plus nanoparticles. Similarly, antioxidants enzymes showed a decreased activity with the same treatment. Our work suggest that therapeutic pulsed ultrasound + dimethyl sulfoxide + gold nanoparticles has beneficial effects on the muscle healing process by inducing a decrease in oxidative stress parameters and most likely decreasing the deleterious effects of the inflammatory response.

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Gold nanoparticles attenuate LPS-induced NO production through the inhibition of NF-κB and IFN-β/STAT1 pathways in RAW264.7 cells

Cited by 96 publications

References 39 publications

<i>Anethum graveloens</i> Flower Extracts Inhibited a Lipopolysaccharide-Induced Inflammatory Response by Blocking iNOS Expression and NF-κB Activity in Macrophages

<i>Anethum graveloens</i> Flower Extracts Inhibited a Lipopolysaccharide-Induced Inflammatory Response by Blocking iNOS Expression and NF-κB Activity in Macrophages

An investigation into the interactions of gold nanoparticles and anti-arthritic drugs with macrophages, and their reactivity towards thioredoxin reductase

Effects of phonophoresis with gold nanoparticles on oxidative stress parameters in a traumatic muscle injury model

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