Gold Nanoparticles/Carbon Nanotubes Composite Film Modified Glassy Carbon Electrode Determination of Meclofenoxate Hydrochloride

Li, Kang; Zhu, Xiaohua; Liang, Yong

doi:10.4236/pp.2012.33036

Cited by 11 publications

(3 citation statements)

References 17 publications

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“…Recently,it is used as a dietary supplement and drug in the treatment of symptoms of senile dementia and Alzheimer's disease [3]. Various methods have been used for MFX determination including HPLC [4,5], proton magnetic resonance spectroscopy [6], cyclic voltammetry [7] and scattering method coupled with flow injection technique [8]. It is obvious that these methods are highly sensitive; however, these techniques are highly expensive due to involving several manipulation steps before reaching the final result of analysis, long analysis time as well as complex instrument setup.…”

Section: Introductionmentioning

confidence: 99%

Novel potentiometric sensors based on carbon and TiO2 nano tubes/ β-cyclodextrin for meclofenoxate hydrochloride micro determination in spiked surface water and urine samples

Khalil

Aleem

2018

Egypt. J. Chem.

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Section: Introductionmentioning

confidence: 99%

Novel potentiometric sensors based on carbon and TiO2 nano tubes/ β-cyclodextrin for meclofenoxate hydrochloride micro determination in spiked surface water and urine samples

Khalil

Aleem

2018

Egypt. J. Chem.

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“…Enhancement of the electrochemical signal, due to introduction of selected nanostructures into electrochemical sensor system, was the goal of many studies described in the literature. [37][38][39][40][41] Introduction of graphene, gold and silica nanoparticles into one system have been investigated many times as well, especially toward catalytic applications. [42][43][44] Due to their properties they are also potentially attractive in the field of electrochemical sensing.…”

mentioning

confidence: 99%

Three-Component EC-SPR Biosensor Based on Graphene Oxide, SiO₂and Gold Nanoparticles in NADH Determination

Breczko

Regulska

Basa

et al. 2016

ECS J. Solid State Sci. Technol.

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The main goal of this paper was to develop a biosensor containing three types of structures: graphene oxide (GO), silica nanoparticles (SNs) and gold nanoparticles (GNPs) for effective electrochemical and optical determination of dihydronicotinamide adenine dinucleotide dehydrogenase (NADH). The subsequent steps in biosensor formation, the manner of structure organization and the layer thickness were verified by different methods. Electrochemical oxidation of NADH was performed with the usage of differential pulse voltammetry method (DPV). Results show that obtained biosensor catalyzes the process of NADH electrochemical oxidation. The shift of oxidation potential toward less positive values and the increment of oxidation current were clearly noted. Additionally, the oxidized NAD form was found to exhibit an electrostatic affinity to the top layer of sensor giving a possibility to SPR detection. DPV and SPR signals registered for different amount of NADH were correlated with its concentration into linear relationship: y = 8.6388x − 0.0109; R2 = 0.9997 and y = 1305.8x − 74.098; R2 = 0.9913, respectively. Enhancement of the electrochemical sensitivity toward NADH, as a result of electrode modification, was proved by lower values of LOD (0.0236 mM) and LOQ (0.0707 mM) in comparison with corresponding parameters calculated for non-modified gold electrode.

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“…17,18 Gold nanoparticles (AuNPs) are one of the most stable metal nanoparticles that provide advantages such as narrow size distribution, large surface to volume ratio, efficient surface modification, enhancement of electron transfer kinetics and desirable biocompatibility. 19 Establishing thermodynamic parameters for electron transfer reactions involving redox process is essential for a complete description of these reactions. The analyte response can be affected by the thermodynamic and kinetic parameters of adsorption, the rate of mass transport and electrochemical behavior of the adsorbed specious.…”

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confidence: 99%

Kinetic and Thermodynamic Approach in the Development of a Voltammetric Sensor for Sunset Yellow

Vikraman

Thomas

Cyriac

et al. 2014

J. Electrochem. Soc.

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An electrochemical sensor was developed for the determination of synthetic food color, sunset yellow (SY), based on the electrocatalytic properties of multiwalled carbon nanotube and gold nanoparticle (MWCNT/AuNP) composite. The glassy carbon electrode (GCE) modified with MWCNT/AuNP nanocomposite film exhibited excellent electron transfer ability toward the oxidation of SY with high sensitivity and stability. A pair of well defined quasi-reversible cyclic voltammetric peaks were observed with the formal potential (E 0 = −108 mV) vs. Ag/AgCl in phosphate buffer solution (PBS). Various kinetic and thermodynamic parameters of the redox reaction such as standard heterogeneous rate constant (k s = 7.944 × 10 −1 s −1 ), electron transfer coefficient (α = 0.487), number of electrons (n = 1) exchanged and free energy of activation ( G) were calculated. Under optimum conditions, the nanocomposite film modified electrode showed a linear response in the range from 1 × 10 −6 to 1 × 10 −5 M, with a limit of detection 4.03 × 10 −8 M. Analytical application of the developed sensor for quantitative determination of SY in commercially available soft drink samples were discussed.Synthetic colourants are usually added to foodstuffs and soft drinks to make them more attractive 1,2 and the use of these dyes in food industry, is strictly controlled by different national legislations. 3 If the colourants are consumed above the acceptable daily level, it may result in allergic reactions, migraine, eczema, anxiety, diarrhea and even cancer. 4,5 Sunset yellow, E 110 (SY) is one of the most commonly used synthetic dye which is added to many food products. The maximum permissible level of SY in food stuffs should not be more than 100 μgmL −1 either individually or in combination with other dyes. 5 Consequently, accurate and reliable methods for the determination of SY are essential for ensuring the quality and safety of food products.Several analytical methods based on spectrophotomery, 6,7 high performance liquid chromatography, 8,9 thin layer chromatography, 10 capillary electrophoresis 11 and column chromatography 12 for the determination of SY individually or in combination with other dyes have been reported. But they are prone to many drawbacks, such as expensiveness, cumbersome procedures and not suitable for field use. Electrochemical methods are also used for the determination of SY and their advantages include high sensitivity, simplicity and low cost and suitability for in-situ determination over conventional classic methods. 4,5,13,14 Integration of nanotechnology with electrochemistry is expected to bring about significant progress in the field of electrochemical sensors. 15 Carbon nanotubes (CNTs), especially multiwalled carbon nanotubes (MWCNTs) have wide applications in electrochemistry due to their small dimensions, high surface area, excellent electrical conductivity, unique structures, significant mechanical strength and good chemical stability, 16 therefore regarded as a potential material to modify the electrode. Recentl...

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Gold Nanoparticles/Carbon Nanotubes Composite Film Modified Glassy Carbon Electrode Determination of Meclofenoxate Hydrochloride

Cited by 11 publications

References 17 publications

Novel potentiometric sensors based on carbon and TiO2 nano tubes/ β-cyclodextrin for meclofenoxate hydrochloride micro determination in spiked surface water and urine samples

Novel potentiometric sensors based on carbon and TiO2 nano tubes/ β-cyclodextrin for meclofenoxate hydrochloride micro determination in spiked surface water and urine samples

Three-Component EC-SPR Biosensor Based on Graphene Oxide, SiO₂and Gold Nanoparticles in NADH Determination

Kinetic and Thermodynamic Approach in the Development of a Voltammetric Sensor for Sunset Yellow

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Gold Nanoparticles/Carbon Nanotubes Composite Film Modified Glassy Carbon Electrode Determination of Meclofenoxate Hydrochloride

Cited by 11 publications

References 17 publications

Novel potentiometric sensors based on carbon and TiO2 nano tubes/ β-cyclodextrin for meclofenoxate hydrochloride micro determination in spiked surface water and urine samples

Novel potentiometric sensors based on carbon and TiO2 nano tubes/ β-cyclodextrin for meclofenoxate hydrochloride micro determination in spiked surface water and urine samples

Three-Component EC-SPR Biosensor Based on Graphene Oxide, SiO2and Gold Nanoparticles in NADH Determination

Kinetic and Thermodynamic Approach in the Development of a Voltammetric Sensor for Sunset Yellow

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Three-Component EC-SPR Biosensor Based on Graphene Oxide, SiO₂and Gold Nanoparticles in NADH Determination