Gold nanoparticles-decorated graphene field-effect transistor biosensor for femtomolar MicroRNA detection

Emerging Biosensing Approaches for microRNA Analysis

“…The sensing mechanism of FETs is illustrated in Figure 10C. Recent efforts have aimed at demonstrating the versatility of this transducer through the use of CMOS-compatible silicon nanowire transistors, 154 gold nanoparticle functionalized graphene FETs, 155 and p19 functionalized FETs, 156 with LODs of 0.13 fM, 10 fM, and 1 aM, respectively. The main drawback of this assay is the shallow sensing depth in solution, which is limited by the Debye length.…”

Biomimetic nanochannels based biosensor for ultrasensitive and label-free detection of nucleic acids

“…Nowadays, various biosensors have been used for nucleic acids detection such as electrochemical sensors (Pollet et al, 2009;Yang et al, 2014;Daniels et al, 2007;Pourmand and Fan, 2008;Berggren et al, 1998), field-effect transistor (FET) biosensor (Cai et al, 2014;Zheng et al, 2015;Cai et al, 2015;Zhang et al, 2010), optical systems (Huang et al, 2011;Akhavan et al, 2012;Panke et al, 2007;Aoki and Tao, 2007;Feng et al, 2008). In particular, most of them usually introduce one dimensional (1D) or two dimensional (2D) nanomaterials to improve sensitivity, and realize label-free detection, because of nanostructure's unique properties.…”

DNA sequencing via Z-shaped graphene nano ribbon field effect transistor decorated with nanoparticles using first-principle transport simulations

“…Decorating graphene membrane with metal nanoparticles affects the membrane sensitivity and selectivity [14]. Various nanoparticles (NPs) such as gold (Au) are commonly used to enhance its performance due to their recognized easy functionalization chemistry [15].…”