Gold Nanoparticles Encapsulated Resveratrol as an Anti-Aging Agent to Delay Cataract Development

Abstract

Nanoparticle-based drug delivery systems, which can overcome the challenges associated with poor aqueous solubility and other harmful side effects of drugs, display potent applications in cataract treatment. Herein, we designed a nanosystem of gold nanoparticles containing resveratrol (RGNPs) as an anti-aging agent to delay cataracts. The spherical RGNPs had a superior ability to inhibit hydrogen peroxide-mediated oxidative stress damage, including reactive oxygen species (ROS) production, malondialdehyde (MDA) generation, and glutathione (GSH) consumption in the lens epithelial cells. Additionally, the present data showed that RGNPs could delay cellular senescence induced by oxidative stress by decreasing the protein levels of p16 and p21, reducing the ratio of BAX/BCL-2 and the senescence-associated secretory phenotype (SASP) in vitro. Moreover, the RGNPs could also clearly relieve sodium selenite-induced lens opacity in a rat cataract model. Our data indicated that cell senescence was reduced and cataracts were delayed upon treatment with RGNPs through activating the Sirt1/Nrf2 signaling pathway. Our findings suggested that RGNPs could serve as an anti-aging ingredient, highlighting their potential to delay cataract development.

Effects of Gold Nanoparticles Phytoreduced with Rutin in an Early Rat Model of Diabetic Retinopathy and Cataracts

“…Gold nanoparticles (AuNPs) have been used in previous medical studies due to their ease of functionalisation with various active molecules [ 20 ]. A recent study [ 21 ] demonstrated significant uptake of AuNPs functionalised with resveratrol, a stilbene from the subclass of dietary polyphenols, in ocular lens epithelial cells, in both in vitro and in vivo models of CA, with no dose-dependent toxicity. Similarly, improvements were demonstrated in a Wistar rat model of diabetic retinopathy when treated with AuNPs phytoreduced with resveratrol [ 22 ].…”

Effects of Gold Nanoparticles Phytoreduced with Rutin in an Early Rat Model of Diabetic Retinopathy and Cataracts

“…Gold nanoparticles (AuNPs) have been used in previous medical studies due to their ease of functionalisation with various active molecules [20]. A recent study [21] demonstrated significant uptake of AuNPs functionalised with resveratrol, a stilbene from the subclass of dietary polyphenols, in ocular lens epithelial cells, in both in vitro and in vivo models of CA, with no dosedependent toxicity. Similarly, improvements were demonstrated in a Wistar rat model of diabetic retinopathy when treated with AuNPs phytoreduced with resveratrol [22].…”

Discovery of a 4-Hydroxy-3′-Trifluoromethoxy-Substituted Resveratrol Derivative as an Anti-Aging Agent

“…Resveratrol, a stilbene derivative, is a natural nutrient in grapes, which possesses many biological characteristics, such as anti-inflammatory, neuroprotective, anti-cancer, anti-oxidative, and anti-diabetic effects [ 11 , 12 , 13 ]. In recent years, the anti-aging potential of resveratrol has been one of the most eye-catching biological activities [ 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ]. Resveratrol is a potential candidate as an anti-aging agent, which can exert its anti-aging and health benefits via anti-oxidative, calorie-restrictive, and anti-inflammatory effects through activating the nuclear factor erythroid 2-related factor 2 (Nrf2), sirtuin 1 (Sirt1), and AMP-activated protein kinase (AMPK) signaling pathways.…”