Gold Nanoparticles Enhance Radiation Therapy at Low Concentrations, and Remain in Tumors for Days

Sah, Bindeshwar; Shrestha, Samana; Wu, Jing; Vanasse, Adam; Cooper, Leon N.; Antosh, Michael

doi:10.1166/jbn.2019.2816

Cited by 7 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mice were anesthetized (isoflurane gas anesthesia) each injected with approximately 1.5 million JC murine adenocarcinoma cells (purchased from American Type Culture Collection (ATCC), Manassas, USA) in cell medium (Roswell Park Memorial Institute). When tumors reached an approximate length of 5–8 mm, similar to [ 20 , 32 , 33 ], mice were anesthetized and injected intratumorally with a 20 μL solution containing 16 μg of Cu-Cy nanoparticles (conjugated to pHLIP) in phosphate buffer solution. Each mouse was given one of three different sizes of nanoparticles: mean size 40, 100, and 300 nm (see Figure 1 A–C below).…”

Section: Methodsmentioning

confidence: 99%

Effects of Nanoparticle Size and Radiation Energy on Copper-Cysteamine Nanoparticles for X-ray Induced Photodynamic Therapy

Sah

Vanasse

et al. 2020

Nanomaterials

Self Cite

View full text Add to dashboard Cite

The Copper-cysteamine (Cu-Cy) nanoparticle is a novel sensitizer with a potential to increase the effectiveness of radiation therapy for cancer treatment. In this work, the effect of nanoparticle size and the energy of X-rays on the effectiveness of radiation therapy are investigated. The effect of the particle size on their performance is very complicated. The nanoparticles with an average size of 300 nm have the most intense photoluminescence, the nanoparticles with the average size of 100 nm have the most reactive oxygen species production upon X-ray irradiation, while the nanoparticles with the average size of 40 nm have the best outcome in the tumor suppression in mice upon X-ray irradiation. For energy, 90 kVp radiation resulted in smaller tumor sizes than 250 kVp or 350 kVp radiation energies. Overall, knowledge of the effect of nanoparticle size and radiation energy on radiation therapy outcomes could be useful for future applications of Cu-Cy nanoparticles.

show abstract

Section: Methodsmentioning

confidence: 99%

Effects of Nanoparticle Size and Radiation Energy on Copper-Cysteamine Nanoparticles for X-ray Induced Photodynamic Therapy

Sah

Vanasse

et al. 2020

Nanomaterials

Self Cite

View full text Add to dashboard Cite

show abstract

“…In vivo studies in tumor-bearing mice revealed efficient tumor-targeted delivery of the gold–pHLIP nanosensitizers and significant reduction in tumor volume at a low administered dosage (10 mg/kg) of the nanosensitizers exposed to 20 Gy of radiation. Biodistribution measurements also demonstrated the enhanced tumor retention of the targeted nanoparticles . Recently, Ding et al demonstrated advanced tumor targeting of ultrasmall gold nanoparticles (Au NPs) by conjugating a multifunctional peptide Tat-R-EK, consisting of the cell-penetrating peptide Tat, a tumor-microenvironment responsive cathepsin B cleavable linker, and a zwitterionic antifouling block.…”

Section: In Situ Activation Via External Triggermentioning

confidence: 99%

“…Biodistribution measurements also demonstrated the enhanced tumor retention of the targeted nanoparticles. 139 Recently, Ding et al demonstrated advanced tumor targeting of ultrasmall gold nanoparticles (Au NPs) by conjugating a multifunctional peptide Tat-R-EK, consisting of the cellpenetrating peptide Tat, a tumor-microenvironment responsive cathepsin B cleavable linker, and a zwitterionic antifouling block. Once targeted within the tumor microenvironment, the locally overexpressed cathepsin B cleaves the peptide linker to expose the cell-penetrating Tat peptide on the Au NP surface, leading to enhanced internalization within the tumor cells.…”

Section: Nanocarriers For Radionuclidesmentioning

confidence: 99%

Transforming Nuclear Medicine with Nanoradiopharmaceuticals

et al. 2022

View full text Add to dashboard Cite

Nuclear medicine is expected to make major advances in cancer diagnosis and therapy; tumor-targeted radiopharmaceuticals preferentially eradicate tumors while causing minimal damage to healthy tissues. The current scope of nuclear medicine can be significantly expanded by integration with nanomedicine, which utilizes nanoparticles for cancer diagnosis and therapy by capitalizing on the increased surface area-to-volume ratio, the passive/active targeting ability and high loading capacity, the greater interaction cross section with biological tissues, the rich surface properties of nanomaterials, the facile decoration of nanomaterials with a plethora of functionalities, and the potential for multiplexing several functionalities within one construct. This review provides a comprehensive discussion of nuclear nanomedicine using tumor-targeted nanoparticles for cancer radiation therapy with either pre-embedded radionuclides or nonradioactive materials which can be extrinsically triggered using various external nuclear particle sources to produce in situ radioactivity. In addition, it describes the prospect of combining nuclear nanomedicine with other modalities to enable synergistically enhanced combination therapies. The review also discusses advances in the fabrication of radionuclides as well as describes laser ablation technologies for producing nanoradiopharmaceuticals, which combine the ease of production with exceptional purity and rapid biodegradability, along with additional imaging or therapeutic functionalities. From a practical standpoint, these attributes of nanoradiopharmaceuticals may provide distinct advantages in diagnostic/therapeutic sensitivity and specificity, imaging resolution, and scalability of turnkey platforms. Coupling image-guided targeted radiation therapy with the possibility of in situ activation of nanomaterials as well as combining with other therapeutic modalities using a multifunctional nanoplatform could herald an era of exciting technological and therapeutic advances to radically transform the landscape of nuclear medicine. The review concludes with a discussion of current challenges and presents the authors’ views on future opportunities to stimulate further research in this rewarding field of high societal impact.

show abstract

“…Gold nanoparticles (NPs) are metallic nanomaterials used widely in the biomedical fields for diagnosis, therapy, and medical imaging together with other industrial applications specially radio biosensors (Chen et al, 2007; Huff et al, 2007; Jain et al, 2007; Sharma et al, 2008). In addition, these nanomaterials have also been used in drug delivery, gene delivery, photothermal therapy, and cancer treatment with special usage in the treatment of benign prostatic hyperplasia and renal cell carcinoma (Al-Trad et al, 2019; Hu et al, 2020; Sah et al, 2019; Yahyaei et al, 2019). Moreover, Au NPs and Au nanoproducts are used in radiation therapy for the treatment of malignant tumors as a result of the high atomic number of gold and the Auger effect of these nanomaterials that facilitate the absorption of X-ray and electron release (Sah et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, these nanomaterials have also been used in drug delivery, gene delivery, photothermal therapy, and cancer treatment with special usage in the treatment of benign prostatic hyperplasia and renal cell carcinoma (Al-Trad et al, 2019; Hu et al, 2020; Sah et al, 2019; Yahyaei et al, 2019). Moreover, Au NPs and Au nanoproducts are used in radiation therapy for the treatment of malignant tumors as a result of the high atomic number of gold and the Auger effect of these nanomaterials that facilitate the absorption of X-ray and electron release (Sah et al, 2019). Also, cell labeling with Au NPs could be involved in molecular imaging in retinal cell therapy and diagnosis (Wang et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

On the toxicity of gold nanoparticles: Histological, histochemical and ultrastructural alterations

et al. 2022

View full text Add to dashboard Cite

Gold nanoparticles (Au NPs) are used in diagnostic and therapeutic applications together with a variety of industrial purposes and in many biomedical sectors with potential risks to human health. The present study aimed to the histological, histochemical, and ultrastructural alterations induced by Au NPS in vital organs. Healthy male Wistar Albino rats ( Rattus norvegicus) were subjected to 20 injections of 10-nm Au NPs at a daily dose of 2 mg/kg. Liver, kidney, heart, and lung biopsies from control and Au NPs-treated rats under study were subjected to histological and histochemical examinations. In comparison with the control rats, the renal tissue of Au NPs-treated rats demonstrated glomerular congestion, interstitial inflammatory cell infiltration, renal tubular hydropic degeneration, cloudy swelling, necrosis, and hyaline cast precipitation. In addition, Au NPs induced the following hepatic alterations: hepatocyte cytolysis, cytoplasmic vacuolation, hydropic degeneration, and nuclear alterations together with sinusoidal dilatation. Moreover, the hearts of the treated rats demonstrated myocarditis, cardiac congestion, hyalinosis, cardiomyocyte hydropic degeneration, myofiber disarray and cardiac congestion. The lungs of Au NPs-treated rats also exhibited the following pulmonary alterations: alectasis, emphysema, inflammatory cell inflammation, thickened alveolar walls, pulmonary interstitial edema, congestion, hypersensitivity, fibrocyte proliferation, and honeycombing. In conclusion, exposure to Au NPs induced histological, histochemical and ultrastructural alterations in the vital organs that may alter the function of these organs. Additional efforts are needed for better understanding the potential risks of Au NPs to human health.

show abstract

Gold Nanoparticles Enhance Radiation Therapy at Low Concentrations, and Remain in Tumors for Days

Cited by 7 publications

References 0 publications

Effects of Nanoparticle Size and Radiation Energy on Copper-Cysteamine Nanoparticles for X-ray Induced Photodynamic Therapy

Effects of Nanoparticle Size and Radiation Energy on Copper-Cysteamine Nanoparticles for X-ray Induced Photodynamic Therapy

Transforming Nuclear Medicine with Nanoradiopharmaceuticals

On the toxicity of gold nanoparticles: Histological, histochemical and ultrastructural alterations

Contact Info

Product

Resources

About