Gold Nanoparticles in Biosensing Analyses

Abstract

Monitoring biomolecular interactions has become a constituent element of various medical and clinical applications. The importance of measuring the biomolecular interaction is evident as a potpourri of sensing strategies is currently and continuously devised. One of the strategies that can immensely enhance the sensitivity of the interaction is the one mediated by nanoparticles. Among the various nanoparticles, gold nanoparticle (AuNP) is opted for due to its capacity to improve the sensitivity and selectivity of biomolecular interactions. In addition to this, AuNP is easy to be manufactured, chemically inert, have uniform dispersibility and are able to react with chemically modified biomolecules. In this overview, the roles adopted by AuNP in various biosensing applications are discussed.

Synthesis of gold nanoparticles using Platycodon grandiflorum extract and its antipathogenic activity under optimal conditions

“…Therefore, there is an urgent need to synthesize effective Au nanoparticles that can combat the growth of various pathogenic bacterial strains. In this study, the antibacterial activity of the synthesized PgAuNPs against E. coli and B. subtilis was assessed at various concentrations of the NP sample (5,10,15, and 20 mg mL À1 ) using the agar diffusion method. Figure 7(a)-(c) shows the diameter of the inhibitory zone produced by PgAuNPs around the disc.…”

“…4,[11][12][13] In addition, AuNPs have applications in chemical and biochemical sensing. 14,15 For the downstream applications with AuNPs, different gold (Au)-mediated nanostructures, such as Au nanourchin, nanofilm, nanostar, nanorod, and other Au-based zerothree-dimensional nanostructures, were generated.…”