Gold Nanoparticles in Chemical and Biological Sensing

Saha, Krishnendu; Agasti, Sarit S.; Kim, Chaekyu; Li, Xiaoning; Rotello, Vincent M.

doi:10.1021/cr2001178

Cited by 4,231 publications

(2,810 citation statements)

References 1,104 publications

(1,589 reference statements)

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“…According to the 3σ rule, the detection limit for human IgG is calculated to be 100 pg/mL, which is at least 1 order of magnitude lower than that of other plasmonic methods 39−41 and even comparable with the results obtained from many sensitive electrochemical methods. 42−45 Additionally, compared to other nanoparticle-based ELISA methods, this method also exhibits many advantages: (1) it is easier to adapt to the conventional ELISA platforms directly, since ALP-labeled antibodies are commercially available; 21,45,53,54 (2) there is no false positive signal coming from nanoparticles autoaggregation, 37,54 as the signal does not come from nanoparticle aggregation; (3) it is label-free for AuNRs, making it much easier to operate; 37,54 and (4) AuNRs are much more stable to light, temperature, and biological thiol than silver nanoprims. 21,22 Determination of Human IgG in Fetal Bovine Serum.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Iodine-Mediated Etching of Gold Nanorods for Plasmonic ELISA Based on Colorimetric Detection of Alkaline Phosphatase

Zhang

Chen

Wang

et al. 2015

ACS Appl. Mater. Interfaces

175

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Here, we propose a plasmonic enzyme-linked immunosorbent assay (ELISA) based on highly sensitive colorimetric detection of alkaline phosphatase (ALP), which is achieved by iodine-mediated etching of gold nanorods (AuNRs). Once the sandwich-type immunocomplex is formed, the ALP bound on the polystyrene microwells will hydrolyze ascorbic acid 2-phosphate into ascorbic acid. Subsequently, iodate is reduced to iodine, a moderate oxidant, which etches AuNRs from rod to sphere in shape. The shape change of AuNRs leads to a blue-shift of longitudinal localized surface plasmon resonance. As a result, the solution of AuNRs changes from blue to red. Benefiting from the highly sensitive detection of ALP, the proposed plasmonic ELISA has achieved an ultralow detection limit (100 pg/mL) for human immunoglobulin G (IgG). Importantly, the visual detection limit (3.0 ng/mL) allows the rapid differential diagnosis with the naked eye. The further detection of human IgG in fetal bovine serum indicates its applicability to the determination of low abundance protein in complex biological samples.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Iodine-Mediated Etching of Gold Nanorods for Plasmonic ELISA Based on Colorimetric Detection of Alkaline Phosphatase

Zhang

Chen

Wang

et al. 2015

ACS Appl. Mater. Interfaces

175

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“…10,11 In response to the challenging task for mercury detection, a variety of colorimetric nanosensors have flourished. 12−20 Those based on the typical DNA aptamer 13−15 or specific ligands, 16−18 functionalized nanomaterials, and the nanosurface oxidation reduction reaction 19,20 have become more and more attractive due to their simplicity, high sensitivity, and selectivity.…”

Section: ■ Introductionmentioning

confidence: 99%

Colorimetric Detection of Mercury Species Based on Functionalized Gold Nanoparticles

Chen

2014

ACS Appl. Mater. Interfaces

225

109

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The speciation analysis of heavy metal pollutants is very important because different species induce different toxicological effects. Nanomaterial-assisted optical sensors have achieved rapid developments, displaying wide applications to heavy metal ions but few to metal speciation analysis. In this work, a novel colorimetric nanosensor strategy for mercury speciation was proposed for the first time, based on the analyte-induced aggregation of gold nanoparticles (Au NPs) with the assistance of a thiol-containing ligand of diethyldithiocarbamate (DDTC). Upon the addition of mercury species, because Hg-DDTC was more stable than Cu-DDTC, a placedisplacement between Hg species and Cu 2+ would occur, and thereby the functionalized Au NPs would aggregate, resulting in a color change. Moreover, by virtue of the masking effect of ethylenediaminetetraacetic acid (EDTA), the nanosensor could readily discriminate organic mercury and inorganic mercury (Hg 2+ ), and it is thus anticipated to shed some light on the colorimetric sensing of organic mercury. So, a direct, simple colorimetric assay for selective determination of Hg species was obtained, presenting high detectability, such as up to 10 nM for Hg 2+ and 15 nM for methylmercury. Meanwhile, the strategy offered excellent selectivity toward mercury species against other metal ions. The simple, rapid, and sensitive label-free colorimetric sensor for the determination of Hg species provided an attractive alternative to conventional methods, which usually involve sophisticated instruments, complicated processes, and long periods of time. More importantly, by using mercury as a model, an excellent nanomaterial-based optical sensing platform can be developed for speciation analysis of trace heavy metals, which can lead to nanomaterials stability change through smart functionalization and reasonable interactions.

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“…In comparison to the maturely developed organic optical sensors, colorimetric assay based on gold nanoparticles (AuNPs) have recently emerged as a fascinating research field [22][23][24][25]. Various metal ions were detected by monitoring the color changes occurring upon aggregation of ligand-functionalized AuNPs through specific molecular interactions [26][27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Incorporation of the fluoride induced SiO bond cleavage and functionalized gold nanoparticle aggregation into one colorimetric probe for highly specific and sensitive detection of fluoride

Sun

Zhang

et al. 2014

Analytica Chimica Acta

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Gold Nanoparticles in Chemical and Biological Sensing

Cited by 4,231 publications

References 1,104 publications

Iodine-Mediated Etching of Gold Nanorods for Plasmonic ELISA Based on Colorimetric Detection of Alkaline Phosphatase

Iodine-Mediated Etching of Gold Nanorods for Plasmonic ELISA Based on Colorimetric Detection of Alkaline Phosphatase

Colorimetric Detection of Mercury Species Based on Functionalized Gold Nanoparticles

Incorporation of the fluoride induced SiO bond cleavage and functionalized gold nanoparticle aggregation into one colorimetric probe for highly specific and sensitive detection of fluoride

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