2020
DOI: 10.1016/j.ejps.2020.105235
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Gold nanoparticles promote a multimodal synergistic cancer therapy strategy by co-delivery of thermo-chemo-radio therapy

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Cited by 78 publications
(35 citation statements)
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“…The level of ROS within KB cells receiving tri-modal therapy was 4.4 times higher than that in control group cells. It also proved the downregulation of Bcl-2 anti-apoptotic factor and the upregulation of a Bax pro-apoptotic factor through analyzing related gene expression [154]. 4.6.2.…”
Section: Trimodal Synergetic Rtmentioning
confidence: 90%
“…The level of ROS within KB cells receiving tri-modal therapy was 4.4 times higher than that in control group cells. It also proved the downregulation of Bcl-2 anti-apoptotic factor and the upregulation of a Bax pro-apoptotic factor through analyzing related gene expression [154]. 4.6.2.…”
Section: Trimodal Synergetic Rtmentioning
confidence: 90%
“…It was widely recognized that AuNPs could be applied for radio-enhancement [19] . Also, it has been identified that AuNPs enhanced a multimodal synergistic cancer therapy strategy by co-delivering thermo-chemo-radio therapy [20] . Besides, radio-sensitization efficacy of AuNPs has been clarified in inhalational nanomedicine of lung cancer treatment [21] .…”
Section: Discussionmentioning
confidence: 99%
“…The gene expression in trimodal therapy group up-regulation of Bax pro-apoptotic factor (by 4.5-fold) and the down-regulation of Bcl-2 anti-apoptotic factor (by 0.3-fold). [ 132 ] Ultrafine AuNPs Modulating microenvironment / Cancer-associated fibroblasts (CAFs) Blocking dominant cells in the microenvironment to eradicate tumors [ 133 ] AuNPs PTT and PDT Black phosphorous nanosheets and cisplatin OSCC Effectively inhibit the metastasis and growth of OSCC, Combination therapy can improve the overall survival rate of golden hamsters. [ 134 ] AuNPs Gum Arabic-encapsulated OTSCC As a promising carrier for chemotherapies to diminish intratumoral hypoxia-stimulated resistance [ 135 ] …”
Section: Application In Oral Cancer Treatmentmentioning
confidence: 99%
“…In recent years, AuNPs-based combination treatment for cancer had been developed [ 42 , 127 ]. Recent reports from the literature had found that AuNPs-based combination therapies, including radiotherapy, chemotherapy, drug delivery, gene therapy, PTT, or PDT are more effective in oral cancer treatment [ 42 , [127] , [128] , [129] , 131 , 132 ]. Here, we have reviewed the recently developed AuNPs-based combination therapy for oral cancer treatment.…”
Section: Application In Oral Cancer Treatmentmentioning
confidence: 99%