Gold Nanorod Based Selective Identification of Escherichia coli Bacteria Using Two-Photon Rayleigh Scattering Spectroscopy

Singh, Anant Kumar; Senapati, Dulal; Wang, Shuguang; Griffin, Jelani; Neely, Adria; Candice, Perry; Naylor, Khaleah M.; Varisli, Birsen; Kalluri, Jhansi Rani; Ray, Paresh Chandra

doi:10.1021/nn9005494

Cited by 179 publications

(189 citation statements)

References 46 publications

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“…SHG, as well as HRS, from individual plasmonic nanospheres has been used to diagnose single-base-mismatch DNA hybridization [141], to detect Alzheimer's disease biomarkers [142], and to probe heavy metal ions [143]. HRS from gold nanorods are used to selectively detect and identify Escherichia coli bacteria [144]. Also, HRS from oval-shaped nanoparticles are used to detect breast cancer cells [145].…”

Section: Inherent Harmonic Generationsmentioning

confidence: 99%

Nonlinear plasmonic imaging techniques and their biological applications

et al. 2016

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Nonlinear optics, when combined with microscopy, is known to provide advantages including novel contrast, deep tissue observation, and minimal invasiveness. In addition, special nonlinearities, such as switch on/off and saturation, can enhance the spatial resolution below the diffraction limit, revolutionizing the field of optical microscopy. These nonlinear imaging techniques are extremely useful for biological studies on various scales from molecules to cells to tissues. Nevertheless, in most cases, nonlinear optical interaction requires strong illumination, typically at least gigawatts per square centimeter intensity. Such strong illumination can cause significant phototoxicity or even photodamage to fragile biological samples. Therefore, it is highly desirable to find mechanisms that allow the reduction of illumination intensity. Surface plasmon, which is the collective oscillation of electrons in metal under light excitation, is capable of significantly enhancing the local field around the metal nanostructures and thus boosting up the efficiency of nonlinear optical interactions of the surrounding materials or of the metal itself. In this mini-review, we discuss the recent progress of plasmonics in nonlinear optical microscopy with a special focus on biological applications. The advancement of nonlinear imaging modalities (including incoherent/ coherent Raman scattering, two/three-photon luminescence, and second/third harmonic generations that have been amalgamated with plasmonics), as well as the novel subdiffraction limit imaging techniques based on nonlinear behaviors of plasmonic scattering, is addressed.

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Section: Inherent Harmonic Generationsmentioning

confidence: 99%

Nonlinear plasmonic imaging techniques and their biological applications

et al. 2016

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“…Along this line, a range of fluorescent DNA sensors was developed using nanoscale metal surfaces. [49][50][51] For example, we constructed multicolor nanobeacons by immobilizing three stem-loop probes labeled with different fluorophores on the surface of 15-nm gold nanoparticles (AuNPs). Three probes labeled with FAM, Cy5 and Rox were designed to target three types of tumor-suppressor genes (exon segments of Scaffolded biosensors H Pei et al p16, p21 and p53), and the nanobeacons could respond to the specific target with negligible crosstalk.…”

Section: Scaffolded Biosensors H Pei Et Almentioning

confidence: 99%

Scaffolded biosensors with designed DNA nanostructures

et al. 2013

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In addition to its fundamental function as a genetic code carrier, the utilization of DNA in various material applications has been actively explored over the past several decades. DNA is intrinsically an excellent type of self-assembly nanomaterial owing to its predictable base-pairing, high chemical stability and the convenience it possesses for synthesis and modification. Because of these unparalleled properties, DNA is widely used as excellent recognition elements in biosensors and as unique building blocks in nanodevices. A critical challenge in surface-based DNA biosensors lies in the reduced accessibility of target molecules to the DNA probes arranged on heterogeneous surfaces, especially when compared to probe-target recognition in homogeneous solutions. To improve the recognition abilities of these heterogeneous surface-confined DNA probes, much effort has been devoted to controlling the surface chemistry, conformation and packing density of the probe molecules, as well as the size and geometry of the surface. In this review, we aim to summarize the recent progress on the improvement of the probetarget recognition properties by introducing DNA nanostructure scaffolds. A range of new strategies have proven to provide a significantly enhanced range in the spatial positioning and the accessibility of the probes to the surface over previously reported linear structures. We will also describe the applications of DNA nanostructure scaffold-based biosensors. INTRODUCTIONDetection of nucleic acids (DNA or RNA) is an integral step in many applications, including in clinical diagnosis, environmental monitoring and antibioterrorism. 1 With these applications in mind, significant efforts have been made to develop sensitive, selective, rapid and cost-effective DNA (or RNA) biosensors. In parallel, DNAbased devices have also attracted a significant, recent interest owing to their promising applications in nanoelectronics, 2,3 biomolecular computations, 4-8 cellular imaging 9 and drug delivery. [10][11][12] In a typical design of DNA biosensors and nanodevices, oligonucleotides are often used as the molecular recognition layer. Because DNA is comprised of only four bases with A-T and G-C pairing, DNA hybridization processes are highly predictable and can be finely tuned with a rational design of the sequence. In addition, DNA oligonucleotides are usually easy to design, chemically stable and cost-effective.Understanding the physical structure of a DNA probe immobilized on a surface is critical in applications using DNA as a molecular recognition element. The properties of the DNA molecular recognition layer (such as selectivity, sensitivity and reproducibility) highly depend on the structure of the self-assembled DNA film. Modeling studies with thiolated DNA have demonstrated that efficient hybridization occurs in the well-controlled condition of surface-attached probes with large interprobe distances and upright conformations. [13][14][15][16][17][18][19][20][21][22][23][24]

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“…Therefore, this sensor is designed to be a presumptive test for the presence or absence of organophosphate, rather than for quantitative analysis of organophosphate. Anti-E. coli antibody conjugated gold nanorods were used to detect E. coli bacteria in water at concentrations of 50 Colony Forming Units mL -1 (136). The detection mechanism was based on the increased two photon Rayleigh scattering observed after addition of E. coli bacteria to the NPs.…”

Section: Metal Nanoparticlesmentioning

confidence: 99%

Nanotechnology Solutions for Global Water Challenges

McGuinness

Garvey

Whelan

et al. 2015

ACS Symposium Series

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The lack of clean and safe drinking water is responsible for more deaths than war, terrorism and weapons of mass destruction combined. This suggests contaminated water poses a significant threat to human health and welfare. In addition, standard water disinfection approaches such as sedimentation, filtration, and chemical or biological degradation are not fully capable of destroying emerging contaminants (e.g. pesticides, pharmaceutical waste products) or certain types of bacteria (e.g. Cryptosporidium parvum). Nanomaterials and nanotechnology based devices can potentially be employed to solve the challenges posed by various contaminants and

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Gold Nanorod Based Selective Identification of Escherichia coli Bacteria Using Two-Photon Rayleigh Scattering Spectroscopy

Cited by 179 publications

References 46 publications

Nonlinear plasmonic imaging techniques and their biological applications

Nonlinear plasmonic imaging techniques and their biological applications

Scaffolded biosensors with designed DNA nanostructures

Nanotechnology Solutions for Global Water Challenges

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