Gold nanorod-mediated hyperthermia enhances the efficacy of HPMA copolymer-90Y conjugates in treatment of prostate tumors

Buckway, Brandon; Frazier, Nick; Gormley, Adam J.; Ray, Abhijit; Ghandehari, Hamidreza

doi:10.1016/j.nucmedbio.2013.12.002

Cited by 45 publications

(26 citation statements)

References 30 publications

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“…MTCP was purchased from Frontier Scientific (UT, USA). HPMA comonomer was synthesized by procedure previously described . Chlorpromazine, Dynasore, Methyl‐β‐cyclodextrin (MβCD), Genistein, Nystatin, Wortmannin, LY294002, Cholchicine, and Elacridar were obtained from Sigma (St. Louis, MO).…”

Section: Experimental Methodsmentioning

confidence: 99%

Comparative Endocytosis Mechanisms and Anticancer Effect of HPMA Copolymer‐ and PAMAM Dendrimer‐MTCP Conjugates for Photodynamic Therapy

Mohammadpour

Safarian

Buckway

et al. 2016

Macromolecular Bioscience

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Polymer architecture can influence biodistribution and the mode of presentation of bioactive agents to cells. Herein, we examined delivery, loading efficiency and mode of cellular entry of polymer conjugates of the photosensitizer Meso-Tetra (4-Carboxyphenyl) Porphyrine (MTCP) when attached to hyper-branched amine terminated poly(amido amine) (PAMAM) dendrimer or random coil linear N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer containing free amines in the side chains. The in vitro dark cytotoxicity and phototoxicity of MTCP and related conjugates were assessed on mouth epidermal carcinoma (KB) and human adenocarcinoma alveolar basal epithelial (A549) cells. Phototoxicity of polymeric conjugates increased by approximately 100 and 4,000 fold in KB and A549 cells compared with non-conjugated MTCP. The increase in phototoxicity activity was shown to result from increased rate of cellular uptake, whereas, cellular internalization of MTCP was negligible in comparison with the conjugated forms. Our results suggest the superiority of amine-terminated HPMA copolymer vs PAMAM dendrimer under study for delivery of MTCP. Treatment with various pharmacological inhibitors of endocytosis showed that polymer architecture influenced the mechanism of cellular uptake of the conjugated photosensitizer. Results show that polymeric conjugates of MTCP improved solubility, influenced the route and the rate of cellular internalization and drastically enhanced the uptake of the photosensitizer.

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Section: Experimental Methodsmentioning

confidence: 99%

Comparative Endocytosis Mechanisms and Anticancer Effect of HPMA Copolymer‐ and PAMAM Dendrimer‐MTCP Conjugates for Photodynamic Therapy

Mohammadpour

Safarian

Buckway

et al. 2016

Macromolecular Bioscience

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“…Several other methods to increase the EPR effect have been investigated, including the use of hyperthermia, PTT, radiofrequency energy and convection-enhanced delivery 144–147 . Despite great promise, more studies are needed to assess the side effects of these treatments, including toxicity to normal tissue and circulation occlusion.…”

Section: Challenges and New Opportunitiesmentioning

confidence: 99%

Rethinking cancer nanotheranostics

et al. 2017

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Advances in nanoparticle synthesis and engineering have produced nanoscale agents affording both therapeutic and diagnostic functions that are often referred to by the portmanteau ‘nanotheranostics’. The field is associated with many applications in the clinic, especially in cancer management. These include patient stratification, drug-release monitoring, imaging-guided focal therapy and post-treatment response monitoring. Recent advances in nanotheranostics have expanded this notion and enabled the characterization of individual tumours, the prediction of nanoparticle–tumour interactions, and the creation of tailor-designed nanomedicines for individualized treatment. Some of these applications require breaking the dogma that a nanotheranostic must combine both therapeutic and diagnostic agents within a single, physical entity; instead, it can be a general approach in which diagnosis and therapy are interwoven to solve clinical issues and improve treatment outcomes. In this Review, we describe the evolution and state of the art of cancer nanotheranostics, with an emphasis on clinical impact and translation.

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“…Recently, 90 Y labeled N-(2-hydroxypropyl) methacrylamide (HPMA) nanoparticle was developed and its treatment efficacy was evaluated in prostate tumor (DU145) bearing mice (101). HPMA copolymer-DOTA conjugates demonstrated efficient labeling and stability for 90 Y and a marked accumulation of these radiolabeled copolymers was observed within prostate tumors.…”

Section: Therapeutic Applicationsmentioning

confidence: 99%

Radio-nanomaterials for biomedical applications: state of the art

Hong

Cai

2016

European Journal of Nanomedicine

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The incorporation of radioactive isotope(s) into conventional nanomaterials can bring extra properties which are not possessed by original materials. The resulting radioactive nanomaterials (radio-nanomaterials), with added physical/chemical properties, can be used as important tools for different biomedical applications. In this review, our goal is to provide an up-to-date overview on these applications using radio-nanomaterials. The first section illustrates the utilization of radionanomaterials for understanding of in vivo kinetics of their parent nano-materials. In the second section, we focus on two primary applications of radio-nanomaterials: imaging and therapeutic delivery. With various methods being used to form radio-nanomaterials, they can be used for positron emission tomography (PET), single-photon emission computed tomography (SPECT), and multimodal imaging. Therapeutic isotopes-loading radio-nanomaterials can possess selective killing efficacy of diseased cells (e.g. tumor cells) and can provide promises for certain isotopes which are not able to be used in a conventional manner. The successful and versatile biomedical applications of radio-nanomaterials warrants further investigations of those materials and their optimizations can pave the way to future imaging guidable, personalized treatments in patients.

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Gold nanorod-mediated hyperthermia enhances the efficacy of HPMA copolymer-90Y conjugates in treatment of prostate tumors

Cited by 45 publications

References 30 publications

Comparative Endocytosis Mechanisms and Anticancer Effect of HPMA Copolymer‐ and PAMAM Dendrimer‐MTCP Conjugates for Photodynamic Therapy

Comparative Endocytosis Mechanisms and Anticancer Effect of HPMA Copolymer‐ and PAMAM Dendrimer‐MTCP Conjugates for Photodynamic Therapy

Rethinking cancer nanotheranostics

Radio-nanomaterials for biomedical applications: state of the art

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