Gold nanoshells with gain-assisted silica core for ultra-sensitive bio-molecular sensors

Tao, Yifei; Guo, Zhongyi; Zhang, Anjun; Zhang, Jingran; Wang, Benyang; Qu, Shiliang

doi:10.1016/j.optcom.2015.03.061

Cited by 25 publications

(10 citation statements)

References 19 publications

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“…However, among all types of gold nanoparticles, gold nanoshells are the ones that consist of an outer gold shell and an inner dielectric core with strong optical properties of absorption and scattering. Their LSPR absorption peak can be adjusted by changing the ratio of the inner and outer diameters [27,28]. Thus, their LSPR absorption band can extend to the near-infrared wavelength (up to 1600 nm) by proper design.…”

Section: Introductionmentioning

confidence: 99%

Label-free and specific detection of soluble programmed death ligand-1 using a localized surface plasmon resonance biosensor based on excessively tilted fiber gratings

Luo

Wang

et al. 2019

Biomed. Opt. Express

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Programmed death ligand-1 (PD-L1) plays an important role in tumor evasion from the host immune system. The level of soluble PD-L1 (sPD-L1) in serum is closely related to tumor aggressiveness and outcomes. This study aimed to propose a localized surface Plasmon resonance (LSPR) biosensor based on excessively tilted fiber grating (ExTFG) coated with large-sized (∼160 nm) gold nanoshells for label-free and specific detection of sPD-L1. The experimental results showed that the limit of detection (LOD) of the immunosensor for sPD-L1 in buffer solutions was ∼1 pg/mL due to the enhanced LSPR effect resulting from the interaction between sPD-L1 molecules and anti-sPD-L1 monoclonal antibodies. The detection of sPD-L1 in complex serum media, such as fetal bovine serum, confirmed that the label-free immunosensor was extremely specific to sPD-L1 and could identify it at a concentration as low as 5 pg/mL. Therefore, it can be potentially applied in clinic for the fast and early diagnosis of cancer.

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Section: Introductionmentioning

confidence: 99%

Label-free and specific detection of soluble programmed death ligand-1 using a localized surface plasmon resonance biosensor based on excessively tilted fiber gratings

Luo

Wang

et al. 2019

Biomed. Opt. Express

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“…In recent years, many researchers have demonstrated that metal nanoparticles, 1 semiconductor nanoparticles 2 and dielectricmetal core-shell nanoparticles (CSNs) 3 have unique and tunable localized surface plasmon resonance (LSPR). [4][5][6][7][8] In particular, the LSPR peaks exhibit red-shi or blue-shi behavior as the structure of the nanoparticle and the refractive index (RI) of the surrounding medium change. The LSPR shis caused by the RI changes have proven useful to detect a variety of chemical changes taking place at the molecular scale, including protein interactions, 9 antigen-antibody binding, 10 inorganic ion sensing, 11 as well as Alzheimer's biomarker recognition.…”

Section: Introductionmentioning

confidence: 99%

Double-exponential refractive index sensitivity of metal–semiconductor core–shell nanoparticles: the effects of dual-plasmon resonances and red-shift

et al. 2018

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“…On another front, introducing active materials (such as dye molecules, rare earth ions, or semiconductor nanocrystals) is an effective method to reduce or compensate the intrinsic losses in plasmonic structures 26 – 31 . In an active nanostructure, when the gain coefficient approaches a critical value, which is called gain threshold, the plasmonic losses can be exactly compensated and thus super-resonance occurs 28 , 32 , 33 . At the gain threshold, the strong coupling between the gain medium and the metal structure will transfer the energy from the gain medium to the SP modes at the resonant frequencies.…”

Section: Introductionmentioning

confidence: 99%

Enhanced Second Harmonic Generation by Mode Matching in Gain-assisted Double-plasmonic Resonance Nanostructure

Pan

Yang

Zhou

et al. 2017

Sci Rep

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We theoretically study the gain-assisted double plasmonic resonances to enhance second harmonic generation (SHG) in a centrosymmetric multilayered silver-dielectric-gold-dielectric (SDGD) nanostructure. Introducing gain media into the dielectric layers can not only compensate the dissipation and lead to giant amplification of surface plasmons (SPs), but also excite local quadrupolar plasmon which can boost SHG by mode matching. Specifically, as the quadrupolar mode dominates SHG in our nanostructure, under the mode matching condition, the intensity of second harmonic near-field can be enhanced by 4.43 × 102 and 1.21 × 105 times when the super-resonance is matched only at the second harmonic (SH) frequency or fundamental frequency, respectively. Moreover, the intensity of SHG near-field is enhanced by as high as 6.55 × 107 times when the nanostructure is tuned to double super-resonances at both fundamental and SH frequencies. The findings in this work have potential applications in the design of nanosensors and nanolasers.

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Gold nanoshells with gain-assisted silica core for ultra-sensitive bio-molecular sensors

Cited by 25 publications

References 19 publications

Label-free and specific detection of soluble programmed death ligand-1 using a localized surface plasmon resonance biosensor based on excessively tilted fiber gratings

Label-free and specific detection of soluble programmed death ligand-1 using a localized surface plasmon resonance biosensor based on excessively tilted fiber gratings

Double-exponential refractive index sensitivity of metal–semiconductor core–shell nanoparticles: the effects of dual-plasmon resonances and red-shift

Enhanced Second Harmonic Generation by Mode Matching in Gain-assisted Double-plasmonic Resonance Nanostructure

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