Gold nanostars for cancer cell-targeted SERS-imaging and NIR light-triggered plasmonic photothermal therapy (PPTT) in the first and second biological windows

Song, Chunyuan; Li, Fang; Guo, Xiangyin; Chen, Wenqiang; Dong, Chen; Zhang, Jingjing; Zhang, Jieyu; Wang, Lianhui

doi:10.1039/c9tb00061e

Cited by 96 publications

(72 citation statements)

References 51 publications

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“…As a result, the limit of detection (LOD) reached femtomolar. Furthermore, Wang's group synthesized 3D flower-like hierarchical gold nanostructures and gold nanostars for cancer therapy (Song et al, 2016, 2018, 2019). The SERS-active gold nanomaterials could use as SERS tags and nanocarriers for cell imaging and drug delivery, which were suitable candidates for promising SERS-imaging.…”

Section: Sers Imagingmentioning

confidence: 99%

Gold Nanomaterials for Imaging-Guided Near-Infrared in vivo Cancer Therapy

Tian

Sheng

Wang

2019

Front. Bioeng. Biotechnol.

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In recent years, tremendous efforts have been devoted into the fields of valuable diagnosis and anticancer treatment, such as real-time imaging, photothermal, and photodynamic therapy, and drug delivery. As promising nanocarriers, gold nanomaterials have attracted widespread attention during the last two decades for cancer diagnosis and therapy due to their prominent properties. With the development of nanoscience and nanotechnology, the fascinating bio-applications of functionalized gold nanomaterials have been gradually developed from in vitro to in vivo. This mini-review emphasizes some recent advances of photothermal imaging (PTI), surface-enhanced Raman scattering (SERS) imaging, and photoacoustic imaging (PAI)-guided based on gold nanomaterials in vivo therapy in near infrared region (>800 nm). We focus on the fundamental strategies, characteristics of bio-imaging modalities involving the advantages of multiples imaging modalities for cancer treatment, and then highlight a few examples of each techniques. Finally, we discuss the perspectives and challenges in gold nanomaterial-based cancer therapy.

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Section: Sers Imagingmentioning

confidence: 99%

Gold Nanomaterials for Imaging-Guided Near-Infrared in vivo Cancer Therapy

Tian

Sheng

Wang

2019

Front. Bioeng. Biotechnol.

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“…AuNSt exhibit a photothermal effect owing to the high molar extinction coefficient in the NIR range [10]. These render AuNSt as suitable agents for photothermal therapy with tunable and adjustable properties [11]. The resonance scattering of visible and near-infrared light upon excitation of their surface plasmon oscillation can be used for optical imaging.…”

Section: Introductionmentioning

confidence: 99%

Au nanostar nanoparticle as a bio-imaging agent and its detection and visualization in biosystems

Perevedentseva

Ali

Lin

et al. 2020

Biomed. Opt. Express

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In the present work, we report the imaging of Au nanostars nanoparticles (AuNSt) and their multifunctional applications in biomedical research and theranostics applications. Their optical and spectroscopic properties are considered for the multimodal imaging purpose. The AuNSt are prepared by the seed-meditated method and characterized for use as an agent for bio-imaging. To demonstrate imaging with AuNSt, penetration and localization in different biological models such as cancer cell culture (A549 lung carcinoma cell), 3D tissue model (multicellular tumor spheroid on the base of human oral squamous carcinoma cell, SAS) and murine skin tissue are studied. AuNSt were visualized using fluorescence lifetime imaging (FLIM) at two-photon excitation with a pulse duration 140 fs, repetition rate 80 MHz and 780 nm wavelength femtosecond laser. Strong emission of AuNSt at two-photon excitation in the near infrared range and fluorescence lifetime less than 0.5 ns were observed. It allows using AuNSt as a fluorescent marker at two-photon fluorescence microscopy and lifetime imaging (FLIM). It was shown that AuNSt can be observed inside a thick sample (tissue and its model). This is the first demonstration using AuNSt as an imaging agent for FLIM at two-photon excitation in biosystems. Increased scattering of near-infrared light upon excitation of AuNSt surface plasmon oscillation was also observed and rendered using a possible contrast agent for optical coherence tomography (OCT). AuNSt detection in a biological system using FLIM is compared with OCT on the model of AuNSt penetrating into animal skin. The AuNSt application for multimodal imaging is discussed.

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“…The main contact surface with the cells are the star arms, causing changes in the cells and leading to cell death [31,32]. However, the toxicity effect of AuS NPs depends also on the concentration of gold nanostars [33]. Therefore, in our experiment, we used the same concentration of AuS1–AuS4 NPs; thus, we can assume that the length of star arms is responsible for the differences in cells death.…”

Section: Resultsmentioning

confidence: 99%

Control of Arms of Au Stars Size and its Dependent Cytotoxicity and Photosensitizer Effects in Photothermal Anticancer Therapy

Depciuch

Stec

Maximenko

et al. 2019

IJMS

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Gold nanostars (AuS NPs) are a very attractive nanomaterial, which is characterized by high effective transduction of the electromagnetic radiation into heat energy. Therefore, AuS NPs can be used as photosensitizers in photothermal therapy (PTT). However, understanding the photothermal conversion efficiency in nanostars is very important to select the most appropriate shape and size of AuS NPs. Therefore, in this article, the synthesis of AuS NPs with different lengths of star arms for potential application in PTT was investigated. Moreover, the formation mechanism of these AuS NPs depending on the reducer concentration is proposed. Transmission electron microscopy (TEM) with selected area diffraction (SEAD) and X-ray diffraction (X-Ray) showed that all the obtained AuS NPs are crystalline and have cores with similar values of the diagonal (parameter d), from 140 nm to 146 nm. However, the widths of the star arm edges (parameter c) and the lengths of the arms (parameter a) vary between 3.75 nm and 193 nm for AuS1 NPs to 6.25 nm and 356 nm for AuS4 NPs. Ultraviolet-visible (UV-Vis) spectra revealed that, with increasing edge widths and lengths of the star arms, the surface plasmon resonance (SPR) peak is shifted to the higher wavelengths, from 640 nm for AuS1 NPs to 770 nm for AuS4 NPs. Moreover, the increase of temperature in the AuS NPs solutions as well as the values of calculated photothermal efficiency grew with the elongation of the star arms. The potential application of AuS NPs in the PTT showed that the highest decrease of viability, around 75%, of cells cultured with AuS NPs and irradiated by lasers was noticed for AuS4 NPs with the longest arms, while the smallest changes were visible for gold nanostars with the shortest arms. The present study shows that photothermal properties of AuS NPs depend on edge widths and lengths of the star arms and the values of photothermal efficiency are higher with the increase of the arm lengths, which is correlated with the reducer concentration.

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Gold nanostars for cancer cell-targeted SERS-imaging and NIR light-triggered plasmonic photothermal therapy (PPTT) in the first and second biological windows

Abstract: Gold nanostars were developed for cancer cell-targeted NIR-I/II SERS-imaging and PPTT.

Cited by 96 publications

References 51 publications

Gold Nanomaterials for Imaging-Guided Near-Infrared in vivo Cancer Therapy

Gold Nanomaterials for Imaging-Guided Near-Infrared in vivo Cancer Therapy

Au nanostar nanoparticle as a bio-imaging agent and its detection and visualization in biosystems

Control of Arms of Au Stars Size and its Dependent Cytotoxicity and Photosensitizer Effects in Photothermal Anticancer Therapy

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