Gold Nanostars for Superficial Diseases: A Promising Tool for Localized Hyperthermia?

Abstract

hyperthermia has been revisited recently thanks to the ability to exploit nanotechnology to obtain in situ treatments and high heat release efficiency."

Synthetic mimetics of the endogenous gastrointestinal nanomineral: Silent constructs that trap macromolecules for intracellular delivery

“…Canonical activation of the inflammasome and IL-1β production usually require a two-signal process 29 but may also arise from lysosomal disruption preceding cell death which can be induced, for example, by the gorging of calcium phosphate nanoparticles 30 . To demonstrate the role of synthetic AMCP in inflammasome activation, blood-derived mononuclear cells were first subjected to vehicle or LPS pre-stimulation to induce pro-IL1β synthesis, and IL-1β production was measured 21 h after a 3 h-challenge with synthetic AMCP.…”

Gold Nanostar Synthesis and Functionalization with Organic Molecules

“…The GNS could also be decorated with mixed lipid-polymer coatings by exploiting thiol chemistry [ 101 ]. This multiple decoration would increase/modify their interaction with skin and enable the nanoparticles' drug delivery capabilities.…”

Applications of Gold Nanostars: Nanosensing, Thermal Therapy, Delivery Systems

“…Nonspherical gold nanoparticles are suitable prospects in this sense due to their capability to locally release heat efficiency when irradiated in NIR region where tissues are transparent [ 3 ]. It has already been mentioned that NIR plasmon resonance of GNS can be tuned in a wide NIR range up to 1250 nm [ 4 ]. Therefore, a brief overview of application of GNS for thermal treatment is made in this subchapter.…”

“…In addition their size and the shape anisotropy essentially determine the position and the amplitude of the NIR-localized surface plasmon resonance [ 3 ]. The shape of the gold nanostars (GNS), in particular, can be tuned from the shape of sea urchin to that of planar, highly regular penta-branched stars [ 4 ]. The NIR-localized surface plasmon resonance of GNS can be consequently tuned in a wide NIR range up to 1250 nm by varying the axial ratio of protruding branches and multiple LSPR band in the NIR can also be obtained [ 4 ].…”

“…The shape of the gold nanostars (GNS), in particular, can be tuned from the shape of sea urchin to that of planar, highly regular penta-branched stars [ 4 ]. The NIR-localized surface plasmon resonance of GNS can be consequently tuned in a wide NIR range up to 1250 nm by varying the axial ratio of protruding branches and multiple LSPR band in the NIR can also be obtained [ 4 ]. The possibility to easily decorate the surface of GNS, in combination with their optical properties…”