Gold nanozyme: Biosensing and therapeutic activities

Sharifi, Majid; Hosseinali, Sara Haji; Yousefvand, Pedram; Salihi, Abbas; Shekha, Mudhir Sabir; Aziz, Falah Mohammad; JouyaTalaei, Amir; Hasan, Anwarul; Falahati, Mojtaba

doi:10.1016/j.msec.2019.110422

“…Some of these studies are more generic [80][81][82][83][84], while some others are specific for gold nanomaterials [14], metal-organic frameworks (MOFs) [85,86] or metal-oxide nanomaterials (MONMs) [87]. Although similar reviews have been published elsewhere, e.g., covering either the factors controlling the activity of gold nanozymes [88] or their potential biosensing and therapeutic applications [89], this review is presented as a comprehensive analysis intending to link both sections, from the fabrication of gold nanozymes, their catalytic mechanisms, potential applications and obstacles in the biomedical field.…”

Section: Catalytic Properties Of Gold Nanoparticlesmentioning

confidence: 99%

Gold Nanozymes: From Concept to Biomedical Applications

Lou-Franco

¹

,

Das

²

,

Elliott

³

et al. 2020

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In recent years, gold nanoparticles have demonstrated excellent enzyme-mimicking activities which resemble those of peroxidase, oxidase, catalase, superoxide dismutase or reductase. This, merged with their ease of synthesis, tunability, biocompatibility and low cost, makes them excellent candidates when compared with biological enzymes for applications in biomedicine or biochemical analyses. Herein, over 200 research papers have been systematically reviewed to present the recent progress on the fundamentals of gold nanozymes and their potential applications. The review reveals that the morphology and surface chemistry of the nanoparticles play an important role in their catalytic properties, as well as external parameters such as pH or temperature. Yet, real applications often require specific biorecognition elements to be immobilized onto the nanozymes, leading to unexpected positive or negative effects on their activity. Thus, rational design of efficient nanozymes remains a challenge of paramount importance. Different implementation paths have already been explored, including the application of peroxidase-like nanozymes for the development of clinical diagnostics or the regulation of oxidative stress within cells via their catalase and superoxide dismutase activities. The review also indicates that it is essential to understand how external parameters may boost or inhibit each of these activities, as more than one of them could coexist. Likewise, further toxicity studies are required to ensure the applicability of gold nanozymes in vivo. Current challenges and future prospects of gold nanozymes are discussed in this review, whose significance can be anticipated in a diverse range of fields beyond biomedicine, such as food safety, environmental analyses or the chemical industry.

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“…Metallic NPs such as Fe, manganese (Mn), copper (Cu), etc. as nanozymes are able to perform chemical reactions in biological solutions [9,41,42]. On the other hand, it has been con rmed that amorphous metallic NZs especially Fe NZs perform better Fenton reactions than bare NZs due to higher ionization and release of metal ions [43].…”

Section: Discussionmentioning

confidence: 99%

Laser-triggered combined chemotherapy and photodynamic therapy enabled by iron sulfide-doxorubicin@bovine lactoferrin nanozymes for breast cancer therapy

Ning¹,

Zheng²,

Qiao³

et al. 2021

Preprint

0

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BackgroundThe use of magnetic nanozymes with the ability to synchronize gas therapy through photodynamic and chemotherapy in the treatment of breast cancer has received much attention. ResultsHence, in this study, we designed a bovine lactoferrin-coated iron sulfide nanozymes containing doxorubicin (FeS-Dox@bLf NZs) by wet chemical synthesis that can respond to tumor acidity. Then, the physicochemical properties of synthesized NZs were investigated by TEM, SEM, DLS and spectroscopic methods. Likewise, the level of Fe2+ release, H2S and Dox from FeS-Dox@Lf NZs under acidic conditions was evaluated. It was observed that Fe2+ and S2- caused significant OH and H2S release through the Fenton reaction. Also, the toxic effects of FeS-Dox@Lf NZs on 4T1 cancerous cells were investigated by MTT and flow cytometry assays. After intravenous injections of NZs and laser irradiation, significant effects of FeS-Dox@Lf NZs on mice weight and tumor status were observed. Afterwards, not only the distribution of Dox in the body was examined by fluorescent, but also the time of Fe clearance and the amount of Dox and Fe retention in vital tissues were determined. The findings confirm that FeS-Dox@Lf NZs, in addition to targeted drug distribution in tumor tissue, resulted in superior therapeutic performance compared to free Dox due to reduced Dox side effects in vital tissues, and increased level of free radicals in 4T1 cells. ConclusionOverall, FeS-Dox@Lf nanozymes with the ability to synchronize chemotherapy and gas therapy raised hopes for more effective treatment of breast cancer.

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“…Metallic NPs such as Fe, manganese (Mn), copper (Cu), etc. as nanozymes are able to perform chemical reactions in biological solutions [9,41,42]. On the other hand, it has been con rmed that amorphous metallic NZs especially Fe NZs perform better Fenton reactions than bare NZs due to higher ionization and release of metal ions [43].…”

Section: Discussionmentioning

confidence: 99%

“…In this regard, the use of magnetic nanoparticles (NPs) with enzyme-like behaviors for producing radicals [3,4] along with the provision of imaging [5], photothermal therapy (PTT) [6], photodynamic therapy (PDT) [7] and chemotherapy [8] have received much attention. The enzymatic-like activity of magnetic NPs induces apoptosis by persuading radicals in cancerous cells through damage of fat, protein and DNA [9,10]. For this purpose, several papers have been published based on iron nanozymes (Fe NZs) that show the formation of radicals through the Fenton reaction on hydrogen peroxide (H 2 O 2 ) inside and outside of cells [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Laser-triggered combined chemotherapy and photodynamic therapy enabled by iron sulfide-doxorubicin@bovine lactoferrin nanozymes for breast cancer therapy

Ning

¹

,

Zheng

²

,

Qiao

³

et al. 2021

Preprint

0

View full text Add to dashboard Cite

BackgroundThe use of magnetic nanozymes with the ability to synchronize gas therapy through photodynamic and chemotherapy in the treatment of breast cancer has received much attention. ResultsHence, in this study, we designed a bovine lactoferrin-coated iron sulfide nanozymes containing doxorubicin (FeS-Dox@bLf NZs) by wet chemical synthesis that can respond to tumor acidity. Then, the physicochemical properties of synthesized NZs were investigated by TEM, SEM, DLS and spectroscopic methods. Likewise, the level of Fe2+ release, H2S and Dox from FeS-Dox@Lf NZs under acidic conditions was evaluated. It was observed that Fe2+ and S2- caused significant OH and H2S release through the Fenton reaction. Also, the toxic effects of FeS-Dox@Lf NZs on 4T1 cancerous cells were investigated by MTT and flow cytometry assays. After intravenous injections of NZs and laser irradiation, significant effects of FeS-Dox@Lf NZs on mice weight and tumor status were observed. Afterwards, not only the distribution of Dox in the body was examined by fluorescent, but also the time of Fe clearance and the amount of Dox and Fe retention in vital tissues were determined. The findings confirm that FeS-Dox@Lf NZs, in addition to targeted drug distribution in tumor tissue, resulted in superior therapeutic performance compared to free Dox due to reduced Dox side effects in vital tissues, and increased level of free radicals in 4T1 cells. ConclusionOverall, FeS-Dox@Lf nanozymes with the ability to synchronize chemotherapy and gas therapy raised hopes for more effective treatment of breast cancer.

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Gold nanozyme: Biosensing and therapeutic activities

Cited by 95 publications

References 94 publications

Gold Nanozymes: From Concept to Biomedical Applications

Gold Nanozymes: From Concept to Biomedical Applications

Laser-triggered combined chemotherapy and photodynamic therapy enabled by iron sulfide-doxorubicin@bovine lactoferrin nanozymes for breast cancer therapy

Laser-triggered combined chemotherapy and photodynamic therapy enabled by iron sulfide-doxorubicin@bovine lactoferrin nanozymes for breast cancer therapy

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