As transhumanist technologies modify human traits, HRM must adapt to new problems and opportunities. This empirical study examines HR policy-making and transhumanist workplace enhancements. The research uses HR professional surveys and case studies from several industries to highlight the limitations of standard techniques in staffing, deploying, and retaining talent. Research suggests ethical principles, inclusivity, and effects on employee performance, health, and workplace attitudes. Very beneficial from a Human Resources viewpoint to understand how complicated transhumanism concerns may be understood in the future and propose policy solutions for more intelligent decision making..