Goldenberry (Physalis peruviana) alleviates hepatic oxidative stress and metabolic syndrome in obese rats

Abstract

The objective of this study was to investigate the effect of goldenberry (GB) (Physalis peruviana) extract supplementation on fat accumulation, hepatic oxidative damage, hepatic fat deposition, inflammation, and hepatic scarring, as well as metabolic syndrome in obese rats. Obesity was induced by feeding rats a high-fat diet for 12 weeks. Female Wister rats were divided into four groups (eight each): control group, obese group, obese + a lowdose GB (200 mg/kg), and obese + a high-dose GB (400 mg/kg). Body mass index (BMI), adipose tissue hormones, lipid profile, liver enzymes, hepatic oxidative stress parameters, and hepatic histopathological changes were assessed. Treating obese rats with GB supplementation reduced their increased body weight, BMI, leptin level, cholesterol, triglycerides, glucose, and insulin resistance index (homeostatic model assessment for insulin resistance). Moreover, the GB regime significantly improved the antioxidant parameters in the liver. In addition, it has shown a significant antiobesity impact by lessening body weight, oxidative damage, BMI, lipids, and insulin insensitivity. Eventually, administration of GB extracts reduced markers of inflammation [tumor necrosis factor-alpha, interleukin (IL)-2, IL-6, and C-reactive protein], fat deposition, steatosis, and fibrosis in the liver of the obese rats. Moreover, GB intake can be used in coupling with a healthy diet to assist obese rats suffering from metabolic syndrome.

Zinc nanoparticles ameliorated obesity-induced cardiovascular disease: role of metabolic syndrome and iron overload

“…Obesity is viewed as a risk agent for several metabolic illnesses, such as hypertension, dyslipidemia, and diabetes, which are closely related to the growth of cardiovascular diseases (CVDs) that lead to abnormalities of the heart and blood vessels 1 , 2 . Obesity is linked with an increased chance of developing insulin resistance that collaborates to generate CVD via atheroma plaque development, ventricular hypertrophy, and diastolic abnormalities 3 .…”

Role of Goldenberry (Fruits with Husk) Extract in Ameliorating the Architecture and Osmotic Fragility of Red Blood Cells in Obese Rats

“…The other two groups of GB extract at a modest dose of 200 or 400 mg DW/kg b.w. (body weight) [ 25 , 26 ] were given orally to obese rats for 2 months.…”

Current investigations for liver fibrosis treatment: between repurposing the FDA-approved drugs and the other emerging approaches

“…As a result, several antioxidants are being examined in clinical studies with positive results, including "S-adenosyl-L-methionine (SAMe), silymarin, phosphatidylcholine, resveratrol, quercetin, N-acetylcysteine (NAC), s-allylcysteine (SAC), oroxylin A, methyl ferulic acid (MFA), vitamin E" and so on [55,56]. In animal models and cell cultures, quercetin, daidzein, resveratrol, cyperus, curcumin, thymol, apigenin, rice bran oil, red yeast rice golden berry, and N-acetylcysteine (NAC) have effectively prevented liver injury and inhibited stellate cell activation [37,[57][58][59][60][61][62][63][64][65][66].…”