GOLGA7 rs11337, a Polymorphism at the MicroRNA Binding Site, Is Associated with Glioma Prognosis

Zhou, Linghui; Dong, Shanshan; Deng, Yao; Yang, Pengfei; Zheng, Yi; Yao, Li; Zhang, Ming; Yang, Shuanying; Wu, Ying; Zhai, Zhen; Li, Na; Kang, Huafeng; Dai, Zhijun

doi:10.1016/j.omtn.2019.08.006

Cited by 15 publications

(14 citation statements)

References 32 publications

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“…Genomic DNA was extracted from peripheral blood using the Universal Genomic DNA Extraction Kit (TaKaRa, Kyoto, Japan) 37 and measured by spectrophotometry (DU530 UV-visible [vis] spectrophotometer; Beckman Instruments, Fullerton, CA, USA). 38 The Multiplexed SNP Mass Extend assay was designed using Sequenom Mass Array Assay Design (version 3.0; Agena Bioscience, San Diego, CA, USA). 39 Sequenom Mass Array RS1000 and Sequenom Typer 4.0 were used for SNP genotyping and data analyses.…”

Section: Methodsmentioning

confidence: 99%

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miR-499 rs3746444 and miR-196a-2 rs11614913 Are Associated with the Risk of Glioma, but Not the Prognosis

Yang

Zheng

Zhou

et al. 2020

Molecular Therapy - Nucleic Acids

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Previous studies of correlations of microRNA (miR)-499 rs3746444 and miR-196a-2 rs11614913 polymorphisms with glioma risk have yielded inconsistent results. In this study, relationships between these two polymorphisms and glioma risk and survival were evaluated. In total, 605 patients and 1,300 controls were genotyped. rs3746444 increased glioma risk in five genetic models (GA versus AA, odds ratio [OR], 95% confidence interval [CI] = 1.31 [1.05–1.66], p = 0.02; GG versus AA, OR [95% CI] = 10.70 [6.13–18.69], p < 0.0001; GA + GG versus AA, OR [95% CI] = 1.82 [1.47–2.24], p < 0.0001; GG versus AA + GA, OR [95% CI] = 9.99 [5.74–17.40], p < 0.0001; G versus A, OR [95% CI] = 2.18 [1.82–2.60], p < 0.0001). rs11614913 decreased glioma risk in a recessive model (OR [95% CI] = 0.79 [0.64–0.97], p = 0.03). No relationships between either SNP and survival were found. rs3746444 in the miR-499 seed region could affect target recognition. Bioinformatics analyses indicated that miR-499 rs3746444 is involved in various biological processes and pathways, including “cell adhesion molecule binding,” “positive regulation of catabolic process,” “NF-kappa B pathway,” and “PI3K-Akt pathway,” by targeting mRNAs. Our results suggested that miR-499 rs3746444 and miR-196a-2 rs11614913 have crucial roles in glioma susceptibility.

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Section: Methodsmentioning

confidence: 99%

“…Data analyses were conducted using R (version 3.5.1). Hardy-Weinberg equilibrium (HWE) was assessed using χ 2 tests, 38 where p >0.05 indicated a balanced equilibrium. Five genetic models were used to evaluate relationships between SNPs and glioma risk.…”

Section: Methodsmentioning

confidence: 99%

miR-499 rs3746444 and miR-196a-2 rs11614913 Are Associated with the Risk of Glioma, but Not the Prognosis

Yang

Zheng

Zhou

et al. 2020

Molecular Therapy - Nucleic Acids

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“…Non-coding RNAs include short hairpin RNA, small interfering RNA, antisense RNA, microRNA (miRNA), long non-coding RNA (lncRNA), circular RNA (circRNA) and extracellular RNAs (18)(19)(20)(21)(22)(23)(24)(25). Increasing evidence suggests that miRNAs, lncRNAs and circRNAs have a vital regulatory function in the pathological process of several diseases, such as cancer (26)(27)(28)(29)(30)(31), cardiac disease (32)(33)(34)(35) and IVDD (36)(37)(38)(39)(40)(41). The structures of miRNAs, lncRNAs and circRNAs are presented in Fig.…”

Section: Introductionmentioning

confidence: 99%

The role of miRNA, lncRNA and circRNA in the development of intervertebral disk degeneration (Review)

Jiang

Sun

et al. 2021

Exp Ther Med

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Intervertebral disc degeneration (IVDD) is a degenerative musculoskeletal disorder with multiple causative factors, such as age, genetics, mechanics and life style. IVDD contributes to non-specific lower back pain (NLBP), which is a globally prevalent and debilitating musculoskeletal disorder. NLBP has a substantial impact on medical resources and creates an economic burden for the public. Dysregulated phenotypes of nucleus pulposus (NP) cells and endplate chondrocytes, such as proliferation, senescence and apoptosis, along with aberrant expression of extracellular matrix components, including type II collagen and aggrecan, are involved in the pathological process of IVDD. Evidence indicates that non-coding RNAs, mainly microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), play a vital role in the development of IVDD. In the present review, the potential molecular mechanisms of miRNAs, lncRNAs and circRNAs in the initiation and progression of IVDD were described based on the latest literature. Furthermore, ways to influence the functions of NP cells and endplate chondrocytes in IVDD were also summarized. The presented insights suggested that non-coding RNAs may function as potential targets for the treatment of IVDD.

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“…For example, single nucleotide polymorphisms (SNPs) within 3′‐UTRs have been shown to affect miRNA‐binding sites 11 or stability 12 of mRNAs, thereby modulating the rate of translation. More in general, polymorphic 3′‐UTRs (p3UTR) could affect gene expression with a variety of phenotypic effects, including a differential predisposition to cancer or a prolonged survival of cancer patients, as it has been shown for glioma, and for breast, gastric, renal and colorectal carcinoma 13‐15 …”

Section: Introductionmentioning

confidence: 99%

“…More in general, polymorphic 3 0 -UTRs (p3UTR) could affect gene expression with a variety of phenotypic effects, including a differential predisposition to cancer or a prolonged survival of cancer patients, as it has been shown for glioma, and for breast, gastric, renal and colorectal carcinoma. [13][14][15] In the present study, we extended the investigation to a set of candidate genes (namely KRAS, VEGFA, SPP1, IRF4, and IL10) involved in pathways relevant for MM pathogenesis, such as apoptosis, B cell differentiation, bone resorption and immunoglobulin production. To this end, we performed a case-control association study within the framework of the International Multiple Myeloma rESEarch (IMMeNSE) consortium, and we found that the p3UTR of IL10 was associated with MM risk and prognosis.…”

mentioning

confidence: 99%

Common gene variants within 3′‐untranslated regions as modulators of multiple myeloma risk and survival

Macauda

Sáinz

Calvetti

et al. 2020

Intl Journal of Cancer

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We evaluated the association between germline genetic variants located within the 3′‐untranlsated region (polymorphic 3′UTR, ie, p3UTR) of candidate genes involved in multiple myeloma (MM). We performed a case‐control study within the International Multiple Myeloma rESEarch (IMMEnSE) consortium, consisting of 3056 MM patients and 1960 controls recruited from eight countries. We selected p3UTR of six genes known to act in different pathways relevant in MM pathogenesis, namely KRAS (rs12587 and rs7973623), VEGFA (rs10434), SPP1 (rs1126772), IRF4 (rs12211228) and IL10 (rs3024496). We found that IL10‐rs3024496 was associated with increased risk of developing MM and with a worse overall survival of MM patients. The variant allele was assayed in a vector expressing eGFP chimerized with the IL10 3′‐UTR and it was found functionally active following transfection in human myeloma cells. In this experiment, the A‐allele caused a lower expression of the reporter gene and this was also in agreement with the in vivo expression of mRNA measured in whole blood as reported in the GTEx portal. Overall, these data are suggestive of an effect of the IL10‐rs3024496 SNP on the regulation of IL10 mRNA expression and it could have clinical implications for better characterization of MM patients in terms of prognosis.

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GOLGA7 rs11337, a Polymorphism at the MicroRNA Binding Site, Is Associated with Glioma Prognosis

Cited by 15 publications

References 32 publications

miR-499 rs3746444 and miR-196a-2 rs11614913 Are Associated with the Risk of Glioma, but Not the Prognosis

miR-499 rs3746444 and miR-196a-2 rs11614913 Are Associated with the Risk of Glioma, but Not the Prognosis

The role of miRNA, lncRNA and circRNA in the development of intervertebral disk degeneration (Review)

Common gene variants within 3′‐untranslated regions as modulators of multiple myeloma risk and survival

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