Golgin A7 family member B (
 GOLGA7B
 ) is a plausible novel gene associating high glycaemic index diet with acne vulgaris

Say, Yee-How; Sio, Yang Yie; Heng, Anna Hwee Sing; Ng, Yu Ting; Matta, Sri Anusha; Pang, Sze Lei; Teh, Keng Foo; Wong, Yi Ru; Shah, Smyrna Moti Rawanan; Reginald, Kavita; Chew, Fook Tim

doi:10.1111/exd.14575

Cited by 7 publications

(6 citation statements)

References 47 publications

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“…In darker skin phototypes, there appears to be a greater subclinical inflammatory response, even in noninflammatory lesions, which is thought to trigger an exaggerated post inflammatory hyperpigmentation (PIH) response and keloid scarring (31), this study found that adolescents of indigenous ethnicity had fewer repercussions from acne. Among the adolescents studied aged 12-17 years, moreover, those who had a parent or siblings with acne also had more acne-related repercussions, knowing that positive family history is a strong predisposing factor in influencing acne presentation, severity and scarring (32). Parental acne was significantly associated with acne presentation and moderate/severe acne, while sibling acne was significantly associated with grade 3/4 scarring (33).…”

Section: Discussionmentioning

confidence: 93%

Factors affecting the quality of life of acne-suffering adolescents in Honduras, Central America, and its repercussions

Espinoza-Turcios

Chinchilla-Castañeda

Sosa-Mendoza

et al. 2023

Preprint

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Introduction: Adolescence is a stage of physical, psychological, and social changes, which determine the personality of the individual, which can be influenced by physical appearance because of alterations in the skin texture of adolescents. Patients with dermatosis have a higher risk of developing depression, anxiety and suicidal ideas. Acne is an important factor for quality of life and affects adolescents both physically and psychosocially. Objective : To determine the factors associated with the repercussions of acne in adolescents in Honduras. Methodology: Analytical cross-sectional study. The Cardiff Acne Disability Index (CADI) scale was used through a questionnaire in Google Forms. Descriptive and analytical statistics were obtained. Results: Of the 3,272 young participants, with respect to quality of life, 25.8% (845) had medium or high repercussions, 5.3% were very depressed by the appearance of their skin in the month prior to filling out the questionnaire. When multivariate analysis was performed, it was found that those who had medium or high repercussions due to acne were women (RPa: 1.33; 95%CI: 1.20-1.48; p-value<0.001), those of indigenous ethnicity (RPa: 1.36; 95%CI: 1.05-1.75; p-value=0.019), those who had scars on the face (RPa: 13.08; 95%CI: 10.02-17.05; p-value<0.001) or those who had the father (RPa: 1.13; 95%CI: 1.01-1.25; p-value=0.031) or siblings with acne (RPa: 1.16; 95%CI: 1.04-1.28; p-value=0.005). Conclusion: It was found that gender, belonging to an indigenous ethnicity, having scars on the face or that having a close relative who had suffered from acne were associated with medium or high repercussions on the quality of life; it is important to take care of acne in this stage of life to avoid repercussions in adulthood.

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Section: Discussionmentioning

confidence: 93%

Factors affecting the quality of life of acne-suffering adolescents in Honduras, Central America, and its repercussions

Espinoza-Turcios

Chinchilla-Castañeda

Sosa-Mendoza

et al. 2023

Preprint

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“…Woodley et al. showed that S-acylated GOLGA7B could interact with and stabilize DHHC5 at the plasma membrane to enhance cell adhesion and restrain cell scatter ( 40 ). Loss of cell adhesion causes loss of contact inhibition, which results in increased cell migration, cell proliferation and cancer progression ( 41 , 42 ).…”

Section: Discussionmentioning

confidence: 99%

Identification of therapeutic targets and prognostic biomarkers in cholangiocarcinoma via WGCNA

Xiao

et al. 2022

Front. Oncol.

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BackgroundCholangiocarcinoma (CCA) is a highly aggressive malignant tumor for which limited treatment methods and prognostic signatures are available. This study aims to identify potential therapeutic targets and prognostic biomarkers for CCA.MethodsBased on differentially expressed genes (DEGs) identified from The Cancer Genome Atlas (TCGA) data, our study identified key gene modules correlated with CCA patient survival by weighted gene coexpression network analysis (WGCNA). Cox regression analysis identified survival-related genes in the key gene modules. The biological properties of the survival-related genes were evaluated by CCK-8 and transwell assays. Then, these genes were used to construct a prognostic signature that was internally and externally validated. Additionally, by combining clinical characteristics with the gene−based prognostic signature, a nomogram for survival prediction was built.ResultsWGCNA divided the 1531 DEGs into four gene modules, and the yellow gene module was significantly associated with overall survival (OS) and histologic neoplasm grade. Our study identified the lncRNA AGAP2−AS1 and a novel gene, GOLGA7B, that are closely related to survival. GOLGA7B downregulation promoted the invasion, migration and proliferation of CCA cells, but AGAP2−AS1 had the opposite effect. AGAP2−AS1 and GOLGA7B were integrated into a gene−based prognostic signature, and both internal and external validation studies confirmed that this two-gene prognostic signature and nomogram could accurately predict CCA patient prognosis.ConclusionAGAP2−AS1 and GOLGA7B are potential therapeutic targets and prognostic biomarkers for CCA.

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“…Furthermore, we derived a novel dietary score (QDGIS) to study the association between GI intake and AD. QDGIS is based on the summation of the GI value and intake frequency of the low and high GI foods that were classified with reference to the international tables of GI and glycaemic load values by Atkinson et al [25, 26]. A specific score was assigned for the frequency of GI foods consumption in terms of the number of times/week based on the rubrics by Manousos et al [27].…”

Section: Methodsmentioning

confidence: 99%

Burgers, Fast Foods, and Increased Associated Risk for Atopic Dermatitis: A Cross-Sectional Study of Dietary Habits among Young Chinese Adults in Singapore/Malaysia

Lim,

et al. 2023

Dermatology

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Background: We see increasing evidence that dietary and nutrients factors play a pivotal role in allergic diseases and recent global findings suggest that dietary habits influence the pathogenesis of atopic dermatitis (AD). Frequent consumption of fast food diets is associated with AD development. Despite the rising prevalence of AD in Asia, efforts in investigating the role of dietary habits and AD in adults are still lacking. Methods: We evaluated the association between the dietary intake of 16 food types and AD manifestations using our Singapore/Malaysia Cross-sectional Genetics Epidemiology Study (SMCGES) population. Dietary habits profiles of 11,494 young Chinese adults (1,550 AD cases/2,978 non-atopic controls/6,386 atopic controls) were assessed by an investigator-administered questionnaire. AD cases were further evaluated for their chronicity (550 chronic) and severity (628 moderate-to-severe). Additionally, we derived a novel food index, Quality of Diet based on Glycaemic Index Score (QDGIS), to examine the association between dietary intake of glycaemic index (GI) and various AD phenotypes. Results: The majority of AD subjects are distributed in the good (37.1%) and moderate (36.2%) QDGIS classes. From the multivariable analyses for age and gender, a moderate QDGIS class was significantly associated with a lower odds of AD (adjusted odds ratio (AOR): 0.844; 95% confidence interval (CI): 0.719–0.991; p < 0.05) and moderate-to-severe AD (AOR: 0.839; 95% CI: 0.714–0.985; p < 0.05). A good QDGIS class was only significantly associated with a lower odds of chronic AD (AOR: 0.769; 95% CI: 0.606–0.976; p < 0.05). Among high GI foods, frequent consumption of burgers/fast food was strongly associated with an increased risk of chronic and moderate-to-severe AD. Among low GI foods, increased intake frequencies of fruits, vegetables, and pulses decreased the odds of AD. Finally, we identified significant associations between frequent seafood, margarine, butter, and pasta consumption with an increased odds of AD despite them having little GI values. Conclusion: While genetic components are well-established in their risks associated with increased AD prevalence, there is still a lack of a focus epidemiology study associating dietary influence with AD. Based on the first allergic epidemiology study conducted here in Singapore and Malaysia, it laid the groundwork to guide potential dietary interventions from changing personal dietary habits.

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Golgin A7 family member B ( GOLGA7B ) is a plausible novel gene associating high glycaemic index diet with acne vulgaris

Cited by 7 publications

References 47 publications

Factors affecting the quality of life of acne-suffering adolescents in Honduras, Central America, and its repercussions

Factors affecting the quality of life of acne-suffering adolescents in Honduras, Central America, and its repercussions

Identification of therapeutic targets and prognostic biomarkers in cholangiocarcinoma via WGCNA

Burgers, Fast Foods, and Increased Associated Risk for Atopic Dermatitis: A Cross-Sectional Study of Dietary Habits among Young Chinese Adults in Singapore/Malaysia

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