Golytely lavage versus a standard colonoscopy preparation

Pockros, Paul J.; Foroozan, Parviz

doi:10.1016/0016-5085(85)90519-0

Cited by 79 publications

(29 citation statements)

References 24 publications

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“…Recruited patients underwent rectal biopsy 8 cm from the anal verge at 0, 3 and 12 months using no bowel preparation or after preparation with polyethyklne glycol and electrolytes (Klean Prep, Norgine, Oxford, UK), which we and others have shown to have no effect on rectal mucosal proliferation and histological appearance (Pockros and Foroozan, 1985;Fireman et al, 1989;Rooney et al, 1993b). A number of samples (usually four or five) were taken, with one being sent for histological confirmation of normality.…”

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confidence: 99%

The effect of calcium supplements on rectal mucosal proliferation

Armitage

Rooney²,

Gifford³

et al. 1995

Br J Cancer

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S rySeventy-nine patients with colorctal adenomata were randomised to receve calcium carbonate (3,000 mg) or plaebo in a double-blnd randomised trial to assms the short-and long-term effects on rectal mucosal proiferation mesued by the in vitro aas arrt technique crypt cell producton rate (CCPR). There was no signifkant difference in mean CCPR between the groups before treatment or after 3 or 12 months. In those paients randonised to calcium, CCPR fel at both 3 months [9.0 (2.8) It is becoming clear that while genetic changes play an important part in the genesis of colorectal cancer the major influences are likely to be dietary (Armstrong, 1975;Fearon and Vogelstein, 1990;Willett et al., 1990). Diet is complex in most societies, and identifying those constituents which substantially influence the risk of colorectal cancer is the subject of much study (Armstrong, 1975;Willett et al., 1990;Thun et al., 1993). The results of such studies are not as yet clear and are often conflicting, but it would appear that a diet which is high in animal fat and low in fibre is associated with a high risk; conversely, a diet low in fat and high in fibre appears to be protective (Armstrong, 1975;Willett et al., 1990).An attempt to modify diet in order to reduce cancer risk is seen as a possible goal. However, there are two major difficulties in determining efficacy in diet intervention. The first is deciding which element of the diet to modify and the second is the end point required. Clarly the best end point is the reduction in mortality from colorectal cancer. However, this would require very large numbers of individuals to be recruited and studied over decades. Intermediate end points have therefore been sought, the most obvious of which is the adenoma, widely held as the benign precursor of most cancers (Morson, 1974). The incidence of new adenomas or the change in size of existing adenomas may be useful, since intervention may cause either a reduction in the number of new adenomas formed in a 'clean colon' or reduction in growth or regression of existing adenomas. Fmally, one can utilise changes in rectal mucosal proliferation. An increase in mucosal proliferation is thought to be an early step in the genesis of colorectal neoplasia (Fearon and Vogelstein, 1990). We have previously shown that individuals at increased risk of colorectal cancer have elevated mucosal proliferation (Rooney et al., 1993a), and this finding has been confirmed by others (Terpstra et al., 1987; Anti et al., 1993). Reduction of rectal mucosal proliferation by an intervention may be evidence of an effect on reduction of risk of colorectal cancer and perhaps a modification of the progression to cancer.A number of investigators have studied the effect of calcium on the risk of colorectal cancer. There is some epidemiological evidence that diets high in calcium may be protective for colorectal cancer (Garland et al., 1985;Sorenson et al., 1988). There is no ckar mechanism of action, but much of its action is thought to be by binding faecal bile acids ...

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confidence: 99%

The effect of calcium supplements on rectal mucosal proliferation

Armitage

Rooney²,

Gifford³

et al. 1995

Br J Cancer

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“…These alterations may be introduced at any point in the acquisition or processing of tissue. Some artifacts are related to the biopsy procedure: edema from colonoscopy preparation, 1 pseudolipomatosis from the colonoscopy procedure, 2 or electrocautery from obtaining the specimen. Other artifacts are induced by the pathologist's handling of the tissue, such as the changes produced by performing a frozen section.…”

Section: We Describe a Distinctive Tissue Artifact That Results From mentioning

confidence: 99%

Biopsy Bag Artifact

1998

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A b s t r a c tArtifacts are an intrinsic component of surgical pathology. In a sense, the standard H&E stain is an intentional artifact, but artifacts are generally regarded as unintentional and typically undesirable alterations of the tissue. These alterations may be introduced at any point in the acquisition or processing of tissue. Some artifacts are related to the biopsy procedure: edema from colonoscopy preparation, 1 pseudolipomatosis from the colonoscopy procedure, 2 or electrocautery from obtaining the specimen. Other artifacts are induced by the pathologist's handling of the tissue, such as the changes produced by performing a frozen section. Still others are introduced through tissue processing.Recently we have observed a distinctive artifact that results from the use of biopsy bags.Biopsy bags are marketed as a convenient means for holding and protecting tissue specimens during histologic processing. With the increasing frequency of small specimens, the use of these bags has become commonplace in many pathology laboratories. We describe the pattern and frequency of this biopsy bag artifact in our practice. Materials and MethodsIn our practice, standard-sized biopsy bags llmage II are routinely used for submitting endometrial biopsy specimens, endocervical curettings, and assorted other small specimens. The specimens are typically received in 10% neutral buffered formalin, having been in fixative for 4 to 18 hours. The contents of the specimen container are then filtered through the tissue specimen bag, the mouth of the bag is closed by folding, and the closed bag is placed in a labeled cassette for standard processing.To assess the frequency, distribution, and severity of the biopsy bag artifact, we reviewed 100 consecutive endometrial samplings (biopsy specimens and curettings) and 100 consecutive endocervical curettings. The slides were assessed for the presence or absence of the artifact, the 2 2 4

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“…Bowel preparation using PEG or other agents has been reported to have negative histopathologic effects on colonic tissue [18][19][20][21]. This detrimental effect of PEG was observed in the human colonic mucosa in a colonoscopy setting, with biopsies taken within a few hours after bowel preparation [18,19]. Histopathologic damage was also observed in rat colonic tissue 4-8 hours after PEG administration [20,21].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, some studies indicated that polyethylene glycol (PEG) and other agents used for bowel preparation may have negative effects on the histopathologic constituency of colonic tissue [18][19][20][21]. Little is known about the effect of PEG on the mechanical properties of the colon and on anastomotic healing.…”

Section: Introductionmentioning

confidence: 99%