2007
DOI: 10.1111/j.1574-6968.2007.00850.x
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Gomesin, a peptide produced by the spiderAcanthoscurria gomesiana, is a potent anticryptococcal agent that acts in synergism with fluconazole

Abstract: Gomesin is an 18-residue cysteine-rich antimicrobial peptide produced by hemocytes of the spider Acanthoscurria gomesiana. In the present study, the antifungal properties of gomesin against Cryptococcus neoformans, the etiologic agent of cryptococcosis, were evaluated. Gomesin bound to the cell surface of cryptococci, which resulted in cell death associated with membrane permeabilization. Antifungal concentrations of gomesin were not toxic for human brain cells. Supplementation of cryptococcal cultures with th… Show more

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Cited by 45 publications
(61 citation statements)
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“…Gomesin bound to the surface of Cryptococcus neoformans, resulting in cell death by membrane permeabilization. Fungal growth, in the presence of the peptide, induced a decrease in capsule expression, rendering cells more susceptible to brain phagocytes and, in association with fluconazole, in concentrations with low antimicrobial activity (0.1-1μM), inhibited fungal growth and enhanced the antimicrobial activity of brain phagocytes (Barbosa et al 2007). One of the models described in the present review is that of gomesin cytotoxicity in murine and human tumor cells .…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Gomesin bound to the surface of Cryptococcus neoformans, resulting in cell death by membrane permeabilization. Fungal growth, in the presence of the peptide, induced a decrease in capsule expression, rendering cells more susceptible to brain phagocytes and, in association with fluconazole, in concentrations with low antimicrobial activity (0.1-1μM), inhibited fungal growth and enhanced the antimicrobial activity of brain phagocytes (Barbosa et al 2007). One of the models described in the present review is that of gomesin cytotoxicity in murine and human tumor cells .…”
Section: Introductionmentioning
confidence: 99%
“…The peptide is active against Grampositive and Gram-negative bacteria, filamentous fungi, yeast (Silva et al 2000), Cryptococcus neoformans (Barbosa et al 2007) and parasites, such as Plasmodium falciparum and Plasmodium berghei (Moreira et al 2007). …”
Section: A Model Of Antitumor Effect Of a Peptidementioning
confidence: 99%
“…Atualmente, a utilização de peptídeos antimicrobianos têm-se mostrado com um grande potencial para aplicações em humanos, outros animais e em plantas (SILVA; DAFFRE; BULET, 2000;BARBOSA et al, 2007;SARIKA;IQUEBAL;RAI, 2012). Trata-se de moléculas pequenas de até 5 kDa que apresentam um amplo espectro de atividade contra microorganismos.…”
Section: Introductionunclassified
“…A atividade antifúngica in vitro da gomesina, já foi reportada por nosso grupo de pesquisa e colaboradores (SILVA et al, 2000;BARBOSA et al, 2007). Entretanto, a atividade antifúngica in vitro da gomesina contra isolados clínicos de Candida albicans resistentes a antifúngicos da classe dos azóis ainda não foi analisada, assim como seu potencial terapêutico contra a candidíase.…”
Section: Discussionunclassified