2011
DOI: 10.1159/000332740
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Gonadal and Sex Differentiation Abnormalities of Dogs and Cats

Abstract: The molecular steps in normal sexual development were largely discovered by studying patients and animal models with disorders of sexual development (DSD). Although several types of DSD have been reported in the cat and dog, which are often strikingly similar to human DSD, these have been infrequently utilized to contribute to our knowledge of mammalian sexual development. Canine and feline cases of DSD with sufficient evidence to be considered as potential models are summarized in this report. The consensus D… Show more

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Cited by 100 publications
(123 citation statements)
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References 169 publications
(79 reference statements)
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“…More difficult to diagnose is a complete reversal of gender, i.e. the lack of phenotypic bisexual traits accompanied by disorders of reproductive function (infertility) (Christensen 2012, Meyers-Wallen 2012.…”
Section: Introductionmentioning
confidence: 99%
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“…More difficult to diagnose is a complete reversal of gender, i.e. the lack of phenotypic bisexual traits accompanied by disorders of reproductive function (infertility) (Christensen 2012, Meyers-Wallen 2012.…”
Section: Introductionmentioning
confidence: 99%
“…Among chromosomal aberrations altering sex development the most common are sex chromosome aneuploidies (mainly monosomy X and trisomy XXY). Also translocation of the Y chromosome fragment carrying the Sry gene into the X chromosome or autosome causes disorders of sex development in XX males (Poth et al 2010, Meyers-Wallen 2012.…”
Section: Introductionmentioning
confidence: 99%
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“…Numerous defects of sexual development in dogs were described by Meyers-Wallen (1993, 1999, who recognized anomalies of chromosomal, gonadal and phenotypic sex. In some situations, chromosomal and gonadal sex agree, but the internal and external genitalia are ambiguous or even alternative.…”
Section: Introductionmentioning
confidence: 99%
“…In some situations, chromosomal and gonadal sex agree, but the internal and external genitalia are ambiguous or even alternative. These cases are categorized as abnormalities of phenotypic sex: male or female pseudo-hermaphrodites (Meyers-Wallen, 1993, 1999.…”
Section: Introductionmentioning
confidence: 99%