Gonadal defects in Cited2 -mutant mice indicate a role for SF1 in both testis and ovary differentiation

Combes, Alexander N.; Spiller, Cassy M.; Harley, Vincent R.; Sinclair, Andrew H.; Dunwoodie, Sally L.; Wilhelm, Dagmar; Koopman, Peter

doi:10.1387/ijdb.092920ac

Cited by 48 publications

(37 citation statements)

References 64 publications

(63 reference statements)

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“…The hsamiR-200c targets were further enriched in several categories of transcription and transcription co-factor activity. Among the transcription cofactors targeted by hsa-miR-200c is Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 (Cited2), which is important in testis development (Combes et al 2010).…”

Section: Discussionmentioning

confidence: 99%

MicroRNA expression profiling of carcinoma in situ cells of the testis

Novotny

Belling²,

Bramsen

et al. 2012

Endocrine-Related Cancer

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Testicular germ cell tumours, seminoma (SE) and non-seminoma (NS), of young adult men develop from a precursor cell, carcinoma in situ (CIS), which resembles foetal gonocytes and retains embryonic pluripotency. We used microarrays to analyse microRNA (miRNA) expression in 12 human testis samples with CIS cells and compared it with miRNA expression profiles of normal adult testis, testis with Sertoli-cell-only that lacks germ cells, testis tumours (SE and embryonal carcinoma (EC), an undifferentiated component of NS) and foetal male and female gonads. Principal components analysis revealed distinct miRNA expression profiles characteristic for each of the different tissue types. We identified several miRNAs that were unique to testis with CIS cells, foetal gonads and testis tumours. These included miRNAs from the hsa-miR-371-373 and -302-367 clusters that have previously been reported in germ cell tumours and three miRNAs (hsa-miR-96, -141 and -200c) that were also expressed in human epididymis. We found several miRNAs that were upregulated in testis tumours: hsa-miR-9, -105 and -182-183-96 clusters were highly expressed in SE, while the hsa-miR-515-526 cluster was high in EC. We conclude that the miRNA expression profile changes during testis development and that the miRNA profile of adult testis with CIS cells shares characteristic similarities with the expression in foetal gonocytes.

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Section: Discussionmentioning

confidence: 99%

MicroRNA expression profiling of carcinoma in situ cells of the testis

Novotny

Belling²,

Bramsen

et al. 2012

Endocrine-Related Cancer

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“…The developmental expression of FOXL2 is also reduced in Cited2 K/K mice. It has been suggested that this could be an indirect effect via the effect of CITED2 on Nr5a1 (Combes et al 2010) required for gonadal and other steroidogenic tissue formation. However, the observed effect on FOXL2 Asterisks represent a Student's t-test P value !10 K3 between the indicated condition and control condition.…”

Section: Regulation Of Foxl2 Expression and Functionmentioning

confidence: 99%

FOXL2: a central transcription factor of the ovary

Georges¹,

Auguste²,

Bessière³

et al. 2013

Journal of Molecular Endocrinology

139

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Forkhead box L2 (FOXL2) is a gene encoding a forkhead transcription factor preferentially expressed in the ovary, the eyelids and the pituitary gland. Its germline mutations are responsible for the blepharophimosis ptosis epicanthus inversus syndrome, which includes eyelid and mild craniofacial defects associated with primary ovarian insufficiency. Recent studies have shown the involvement of FOXL2 in virtually all stages of ovarian development and function, as well as in granulosa cell (GC)-related pathologies. A central role of FOXL2 is the lifetime maintenance of GC identity through the repression of testis-specific genes. Recently, a highly recurrent somatic FOXL2 mutation leading to the p.C134W subtitution has been linked to the development of GC tumours in the adult, which account for up to 5% of ovarian malignancies. In this review, we summarise data on FOXL2 modulators, targets, partners and post-translational modifications. Despite the progresses made thus far, a better understanding of the impact of FOXL2 mutations and of the molecular aspects of its function is required to rationalise its implication in various pathophysiological processes.

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“…One such example involves the transcription factor SF1 (which is commonly considered a marker for the Sertoli cell lineage) and its cofactor Cbp/p300-interacting transactivator 2 (CITED2). By looking at a Cited2 -/-mouse and the resulting decrease in SF1 activity, researchers discovered that in XY mice SF1/CITED2 function is important for proper testis architecture, but in XX gonads SF1/CITED2 signaling is also crucial for female patterning and without it there is ectopic mesonephric cell migration (Combes et al 2010) (Fig. 4.4).…”

Section: Fgf9mentioning

confidence: 99%

Mesonephric Cell Migration into the Gonads and Vascularization Are Processes Crucial for Testis Development

Romereim

Cupp

2016

Results and Problems in Cell Differentiation

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Testis morphogenesis requires the integration and reorganization of multiple cell types from several sources, one of the more notable being the mesonephric-derived cell population. One of the earliest sex-specific morphogenetic events in the gonad is a wave of endothelial cell migration from the mesonephros that is crucial for (1) partitioning the gonad into domains for testis cords, (2) providing the vasculature of the testis, and (3) signaling to cells both within the gonad and beyond it to coordinately regulate testis development. In addition to endothelial cell migration, there is evidence that precursors of peritubular myoid cells migrate from the mesonephros, an event which is also important for testis cord architecture. Investigation of the mesonephric cell migration event has utilized histology, lineage tracing with mouse genetic markers, and many studies of the signaling molecules/pathways involved. Some of the more well-studied signaling molecules involved include vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and neurotrophins. In this chapter, the morphogenetic events, relevant signaling pathways, mechanisms underlying the migration, and the role of the migratory cells within the testis will be discussed. Overall, the migration of mesonephric cells into the early testis is indispensable for its development and future functionality.

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Gonadal defects in Cited2 -mutant mice indicate a role for SF1 in both testis and ovary differentiation

Cited by 48 publications

References 64 publications

MicroRNA expression profiling of carcinoma in situ cells of the testis

MicroRNA expression profiling of carcinoma in situ cells of the testis

FOXL2: a central transcription factor of the ovary

Mesonephric Cell Migration into the Gonads and Vascularization Are Processes Crucial for Testis Development

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