Gonadal function in young adult males with metabolic syndrome

Choudhury, Bipul Kumar; Choudhury, Saswati Sanyal; Saikia, Uma Kaimal; Sarma, Debajit

doi:10.1016/j.dsx.2013.06.013

Cited by 7 publications

(5 citation statements)

References 23 publications

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“…[67] Hypogonadism with low testosterone and low sex hormone-binding globulin (SHBG) levels in young adults with MetS have been reported previously from our centre. [8] Data on the defects in spermatogenesis in adult males with the MetS are lacking from North East India. The present study was designed to assess the presence of hypogonadism and Sertoli cell dysfunction in young adult males with MetS.…”

Section: Introductionmentioning

confidence: 99%

Sertoli cell function in young males with metabolic syndrome

Saikia

Sarma

et al. 2019

Indian J Endocr Metab

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Context: The last few decades have witnessed an alarming increase in the prevalence of the metabolic syndrome (MetS) worldwide including India. Apart from the known risks of MetS in terms of cardiovascular risk and mortality, there is increasing evidence that it also leads to alteration in testicular function and fertility. Aims: To assess the presence of hypogonadism and Sertoli cell dysfunction in young adult males with MetS and correlate these parameters with different components of the MetS. Settings and Design: Cross-sectional study conducted in the Department of Endocrinology, Gauhati Medical College, a tertiary care hospital in North East India. Subjects and Methods: Young adult males with MetS aged 20–40 years and age-matched healthy males who served as controls were examined clinically. Laboratory investigations done in the fasting state included blood glucose, lipid profile, serum follicle-stimulating hormone (FSH), inhibin B and total testosterone (Te). Semen was collected after 3 days abstinence and analysis done. Statistical Analysis: Baseline parameters were presented as median and ‘Kruskal–Wallis’ test was used to compare them. Pearson test and multiple regression analysis were used to assess the correlation and association between variables. Results: Fifty cases with MetS and 30 controls were included in the study. Subjects with MetS had significantly lower levels of total Te, FSH and inhibin B. They also had significantly lower semen volume, sperm count and total as well as progressive motility. There was a significant negative correlation of waist circumference and positive correlation of inhibin B with total sperm count. A significant negative association of serum triglycerides with semen volume was also found. Conclusion: MetS is a state of hypogonadotropic hypogonadism as reflected by low total Te, FSH and inhibin B levels with semen abnormalities reflecting Sertoli cell dysfunction.

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Section: Introductionmentioning

confidence: 99%

Sertoli cell function in young males with metabolic syndrome

Saikia

Sarma

et al. 2019

Indian J Endocr Metab

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“…On the other hand, it is thought that MS may threaten reproductive health due to its adverse effects on fertility in males (Cheung et al, 2015; Rovira‐Llopis et al, 2017). Moreover, previous researches have indicated that MS leads to reduced FSH, LH and T levels (Choudhury et al, 2013; El‐Mehi & Faried, 2020; Hart et al, 2019; Yildirim et al, 2019). Our findings that demonstrated the decreased hormone levels due to MS in male rats are consistent with the data in the literature.…”

Section: Discussionmentioning

confidence: 99%

The therapeutic effects of distinct exercise types on metabolic syndrome‐induced reproductive system impairment in male rats: Potential contribution of mitochondria‐related genes

Karaman

Tektemur

2022

Andrologia

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A sedentary lifestyle and high fructose dietary habits cause diseases, such as metabolic syndrome (MS). The study was aimed to investigate the potential ameliorative effects of different exercise interventions on high fructose‐induced MS‐mediated reproductive system disruption of male rats. Rats were divided into four groups (n = 6): Control, MS, MS+aerobic exercise (AE) and MS+anaerobic exercise (ANE). MS was induced by using tap water containing 30% fructose for 8 weeks. After the induction of MS, AE/ANE implementations were started for 6 weeks. Testis tissue and serum samples of rats were stored for biochemical and molecular analyses. Serum total antioxidant status level increased in the MS+AE group compared to all groups. Also, serum total oxidant status level, which increased by MS, decreased with AE, but not altered with ANE. Moreover, MS markedly decreased serum luteinizing hormone, but not changed the follicle‐stimulating hormone. However, serum hormone levels were similar to the control group in both MS+AE and MS+ANE groups. MS upregulated mitochondria‐related genes' mRNA expressions (MFN2, PGC1A, PPARG, PARP2 and TXNL4B). These increases, except for PPARG, were normalized with both exercise types. These results revealed that mitochondria‐related genes may have a crucial role in MS‐mediated male reproductive impairment and therapeutic effects of exercises.

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“…Studies have shown that SHBG, as well as serum testosterone levels, increases continuously during childhood and gradually decreases in both genders between the ages of 20 and 30 years (53). A survey of men aged 20–40 years with MetS showed significantly lower SHBG levels compared to controls (54). Men with MetS had lower levels of total testosterone, bioavailable testosterone, free testosterone, or SHBG than men without MetS.…”

Section: Discussionmentioning

confidence: 99%

Gender Differences in the Prevalence and Clinical Correlates of Metabolic Syndrome in First-Episode and Drug-Naïve Patients With Major Depressive Disorder

Zhang,

Wang,

Wang

et al. 2024

Psychosom Med

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Objective Major depressive disorder (MDD) is a severe psychiatric symptom worldwide, and the coexistence of MDD with metabolic syndrome (MetS) is common in clinical practice. However, gender differences in comorbid MetS in first-episode and drug-naïve (FEDN) MDD patients have not been reported. Here, we explored potential gender differences in the prevalence and clinical correlates of comorbid MetS in FEDN MDD patients. Methods A cross-sectional study of 1718 FEDN MDD patients was conducted. Demographic and clinical data were collected. The Hamilton depression scale (HAMD), Hamilton anxiety scale (HAMA), and Positive and Negative Syndrome Scale (PANSS) positive subscale were used to evaluate depression, anxiety, and psychotic symptoms, respectively. Results The prevalence of MetS was 1.645-fold higher in female MDD patients (38.50%) than in male patients (26.53%). Patients with MetS had higher HAMD score, HAMA score, and PANSS positive subscale score than patients without MetS (p's < 0.001). Furthermore, suicide attempts (male: OR = 1.706, p = 0.034; female: OR = 1.639, p = 0.004) and HAMD score (male: OR = 1.251, p < 0.001; female: OR = 1.148, p < 0.001) were independently associated with MetS in male and female patients, whereas age of onset was independently associated with MetS only in female patients (OR = 1.744, p = 0.047). Conclusion Our findings suggest significant gender differences in the prevalence and clinical correlates of comorbid MetS in FEDN MDD patients. Clinical variables (suicide attempts and HAMD scores) may be independently associated with MetS in MDD patients.

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Gonadal function in young adult males with metabolic syndrome

Cited by 7 publications

References 23 publications

Sertoli cell function in young males with metabolic syndrome

Sertoli cell function in young males with metabolic syndrome

The therapeutic effects of distinct exercise types on metabolic syndrome‐induced reproductive system impairment in male rats: Potential contribution of mitochondria‐related genes

Gender Differences in the Prevalence and Clinical Correlates of Metabolic Syndrome in First-Episode and Drug-Naïve Patients With Major Depressive Disorder

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