Gonadal hormones and body temperature in rats: Effects of estrous cycles, castration and steroid replacement

Marrone, Babetta L.; Gentry, R. Thomas; Wade, George N.

doi:10.1016/0031-9384(76)90101-3

Cited by 100 publications

(58 citation statements)

References 17 publications

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“…Hence lowered leptin levels, in lactation, seem an unlikely candidate to stimulate T b . However, T b was significantly suppressed by the removal of the adrenal glands and the ovaries from female rats Leon et al, 1985;Marrone et al, 1976), pointing to additional hormonal drivers that could be involved.…”

Section: Physical Activity and Body Temperature In Lactating Micementioning

confidence: 97%

Limits to sustained energy intake XX: body temperatures and physical activity of female mice during lactation

Gamo

Troup

Mitchell

et al. 2013

Journal of Experimental Biology

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SUMMARYLactating animals consume greater amounts of food than non-reproductive animals, but energy intake appears to be limited in late lactation. The heat dissipation limit theory suggests that the food intake of lactating mice is limited by the capacity of the mother to dissipate heat. Lactating mice should therefore have high body temperatures (T b ), and changes in energy intake during lactation should be reflected by variation in T b . To investigate these predictions, 26 mice (Mus musculus) were monitored daily throughout lactation for food intake, body mass, litter size and litter mass. After weaning, 21days postpartum, maternal food intake and body mass were monitored for another 10days. Maternal activity and T b were recorded every minute for 23h a day using implanted transmitters (vital view). Energy intake increased to a plateau in late lactation (days 13-17). Daily gain in pup mass declined during this same period, suggesting a limit on maternal energy intake. Litter size and litter mass were positively related to maternal energy intake and body mass. Activity levels were constantly low, and mice with the largest increase in energy intake at peak lactation had the lowest activity. T b rose sharply after parturition and the circadian rhythm became compressed within a small range. T b during the light period increased considerably (1.1°C higher than in baseline), and lactating mice faced chronic hyperthermia, despite their activity levels in lactation being approximately halved. Average T b increased in relation to energy intake as lactation progressed, but there was no relationship between litter size or litter mass and the mean T b at peak lactation. These data are consistent with the heat dissipation limit theory, which suggests performance in late lactation is constrained by the ability to dissipate body heat. Supplementary material available online at

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Section: Physical Activity and Body Temperature In Lactating Micementioning

confidence: 97%

Limits to sustained energy intake XX: body temperatures and physical activity of female mice during lactation

Gamo

Troup

Mitchell

et al. 2013

Journal of Experimental Biology

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“…Thermic effect of food is known to increase energy 82 expenditure and thermogenesis (Rothwell & Stock 1979, Cannon & Nedergaard 2004 whereas stress causes an increase both in blood glucose concentration and body temperature 84 via stress hormones and stress related behaviour (Vachon & Moreau 2001, Blanchard, 85 Griebel & Blanchard 2001. In females, the stage of estrous cycle is known to affect the body 86 temperature; temperature increases during proestrus, when progesterone and estrogen 87 concentrations are highest, while during estrus there is a drop in body temperature (Kent, 88 Hurd & Satinoff 1991, Marrone, Gentry & Wade 1976). 89 90…”

Section: Voluntary Running Aids To Maintain High Thermo-genesis Inmentioning

confidence: 99%

Effects of intrinsic aerobic capacity, aging and voluntary running on skeletal muscle sirtuins and heat shock proteins

Karvinen

Silvennoinen

Vainio

et al. 2016

Experimental Gerontology

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“…A speculative possibility is that the correlation between ingestive behavior and T b is blunted on E because hormonal changes related to estrus provide an added source of thermogenesis on E (13,20), perhaps including the thermal consequences of increased locomotor activity (9,18). However, there was evidence of greater thermogenesis in the dark phase of E only for SHR.…”

Section: Relationship Between Ingestive Behavior and T Bmentioning

confidence: 99%

“…Because both strains were housed in standard laboratory cages, we expected a sawtooth pattern in T b on nonestrous days, as previously reported for SD rats in similar housing conditions (18), and we predicted that peaks in the sawtooth pattern would be closely related to ingestive activity as suggested by studies showing elevated T b during eating. Because hormonal changes surrounding E are thermogenic (13,20,23), we also predicted that the relationship between ingestive behavior and T b may be weakened on E.…”

mentioning

confidence: 98%

Ingestive behavior and body temperature during the ovarian cycle in normotensive and hypertensive rats

Rashotte¹,

Ackert²,

Overton

2002

American Journal of Physiology-Regulatory, Integrative and Comp

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Rashotte, Michael E., Allison M. Ackert, and J. Michael Overton. Ingestive behavior and body temperature during the ovarian cycle in normotensive and hypertensive rats. Am J Physiol Regulatory Integrative Comp Physiol 282: R216-R225, 2002; 10.1152/ajpregu.00676.2000.-The relationship between ingestive behavior (eating ϩ drinking) and core body temperature (Tb) in naturally cycling female rats was compared in a normotensive strain (Sprague-Dawley; SD) and a hypertensive strain reputed to have chronically elevated Tb (spontaneously hypertensive rats; SHR). Tb (by telemetry) and ingestive behavior (automated recording) were quantified every 30 s. Ingestive behavior and Tb were related on all days of the ovarian cycle in both strains, but the strength of that relationship was reduced on the day of estrus (E) compared with nonestrous days. Several strain differences in Tb were found as well. In SHR, dark-phase Tb was elevated on E, whereas SD remained at the lower nonestrous values. Fluctuations in dark-phase Tb were correlated with ingestive behavior in both strains but had greater amplitude in SHR except on E. Short-term fasting or sucrose availability did not eliminate elevated dark-phase Tb on E in SHR. We propose that estrus-related changes unique to SHR may indicate heightened thermal reactivity to hormonal changes, ingestive behavior, and general locomotor activity.spontaneously hypertensive rat; Sprague-Dawley rat; estrus; telemetry; feeding; drinking; fasting; sucrose THE RELATIONSHIP between ingestive behavior (eating and drinking) and body temperature (T b ), of interest for decades (1,3,4,15), has been studied in several species. For example, brain temperature in rats and cats begins to increase a few minutes after eating or drinking is initiated (16), skin and liver temperature become elevated during eating in rats (7), and skin temperature in the vicinity of the liver increases in normal-weight humans during consumption of a meal (32). Ingestive behavior and T b have separately been shown to vary across days of the ovarian cycle, but there is no information about the relationship between the two measures during the cycle. The present study, which characterizes the relationship between ingestive behavior and T b in naturally cycling female rats from two strains, provides the first data on whether the relationship is constant during the cycle and whether it is similar in different strains.It is well known that the ovarian cycle influences ingestive behavior in rats of several strains. Daily intake of food and water is relatively invariant on the preestrous days of a typical 4-day cycle [diestrus 1 (D1), diestrus 2 (D2), and proestrus (P)], but on the day of estrus (E) intake of both food and water, it decreases (5, 9, 11, 29, 31). The decrease in food consumption on E is always associated with a decrease in the size of individual feeding bouts, but the frequency of bouts has been reported to increase on E (2, 9, 19, 30) or to remain the same as on other days in the cycle (8, 10). Changes in drinking-bout...

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Gonadal hormones and body temperature in rats: Effects of estrous cycles, castration and steroid replacement

Cited by 100 publications

References 17 publications

Limits to sustained energy intake XX: body temperatures and physical activity of female mice during lactation

Limits to sustained energy intake XX: body temperatures and physical activity of female mice during lactation

Effects of intrinsic aerobic capacity, aging and voluntary running on skeletal muscle sirtuins and heat shock proteins

Ingestive behavior and body temperature during the ovarian cycle in normotensive and hypertensive rats

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