Gonadal hormones and oxidative stress interaction differentially affects survival of male and female mice after lung<i>Klebsiella Pneumoniae</i>infection

Durrani, Faryal; Phelps, David S.; Weisz, Judith; Silveyra, Patricia; Hu, Sanmei; Mikerov, Anatoly N.; Floros, Joanna

doi:10.3109/01902148.2011.654045

Cited by 44 publications

(64 citation statements)

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“…We have shown that male and female mice differ in their abilities to combat infection, and that oxidative stress, in the form of acute ozone exposure, affects this response [18,21,22,26,27]. Our goal in the current study was to study BAL factors that may contribute to these differences.…”

Section: Discussionmentioning

confidence: 99%

“…In a series of publications we have described sex differences [18,21,22,26,27] in outcome after infecting mice with Klebsiella pneumoniae , with or without a prior oxidative stress in the form of an acute ozone exposure. The above studies include differences in survival and phagogcytosis of pathogens by alveolar macrophages [18,21,25] as well as differences in histopathology and dissemination of the resulting infection [22,27].…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, we have shown that the sex differences persist and are accentuated in mice lacking SP-A or after the oxidative modification of SP-A [18,21]. The sex differences in survival have been shown to be dependent upon gonadal hormones [26]. A further insight into the molecular basis of the sex differences has been gained via the study of the proteome of alveolar macrophages from mice lacking SP-A and after a “rescue” of these mice with exogenous SP-A [3,4].…”

Section: Introductionmentioning

confidence: 99%

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Effect of ozone exposure and infection on bronchoalveolar lavage: Sex differences in response patterns

et al. 2014

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Female mice exhibit a better survival rate than males after infection, but if infection follows an ozone-induced oxidative stress, male survival exceeds that of females. Our goal was to study bronchoalveolar lavage factors that contribute to these sex differences in outcome. We studied parameters at 4, 24, and 48 hours after ozone exposure and infection, including markers of inflammation, oxidative stress, and tissue damage, and surfactant phospholipids and surfactant protein A (SP-A). A multianalyte immunoassay at the 4 hr time point measured 59 different cytokines, chemokines, and other proteins. We found that: 1) Although some parameters studied revealed sex differences, no sex differences were observed in LDH, total protein, MIP-2, and SP-A. Males showed more intragroup significant differences in SP-A between filtered air- and ozone-exposed mice compared to females. 2) Oxidized dimeric SP-A was higher in FA-exposed female mice. 3) Surfactant phospholipids were typically higher in males. 4) The multianalyte data revealed differences in the exuberance of responses under different conditions - males in response to infection and females in response to oxidative stress. These more exuberant, and presumably less well-controlled responses associate with the poorer survival. We postulate that the collective effects of these sex differences in response patterns of lung immune cells may contribute to the clinical outcomes previously observed.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of ozone exposure and infection on bronchoalveolar lavage: Sex differences in response patterns

et al. 2014

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“…Exposure to air pollutants has been linked to negative lung health outcomes, and both male an important role in the predisposition of some respiratory infections [11,12]. Although some studies in animals have shown that females are more resistant than males to some bacterial infections [13,14], others have shown that these patterns are reversed if animals are pre-exposed to environmental pollutants, such as ozone [15][16][17][18][19][20]. Incidentally, some clinical studies have reported that men are more susceptible to developing CAP and receive more intensive care than women, and show increased risk to die from pneumonia [21].…”

Section: Introductionmentioning

confidence: 99%

Understanding the Intersection of Environmental Pollution, Pneumonia, and Inflammation: Does Gender Play a Role?

Silveyra¹,

Fuentes²,

Rivera³

2017

Contemporary Topics of Pneumonia

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Accumulating evidence indicates that exposure to air pollution is associated with increased mortality from respiratory disease. Exposure to ambient pollutants, such as ozone, particulate matter, sulfur dioxide, nitrogen dioxide, and other agents has been associated with decrease in lung function and immunity, and with increased rates of hospitalization for lung disease, including pneumonia. Furthermore, sex differences in frequency and severity of pulmonary disease and infection have been reported, suggesting a role of sex hormones in mediating these differences. Pneumonia, which is commonly caused by bacterial infection and subsequent lung inflammation leading to hospitalization and death, occurs at different rates in men and women. In this context, male and female hormones can have direct effects on the immunity system by binding to receptors in immune cells, and these responses can be modulated by environmental exposures. This chapter summarizes clinical, animal, and epidemiological studies linking exposure to air pollution and pneumonia in both males and females. Understanding sex-specific mechanisms in pneumonia pathogenesis and environmental responses can help in the development of more effective therapeutics and treatment options to reduce negative health outcomes in men and women.

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“…Further, non-WTC exposures, such as smoking and air pollution, have demonstrated a disproportional impact on women, who are at increased risk for reduced lung function, obstructive airways disease (OAD) and lung cancer 9–13. Sex hormones may play a role as they are associated with the regulation of lung innate immunity and inflammation 14. For these reasons, federally funded research mandates that sex and race/ethnicity effects be examined 15…”

Section: Introductionmentioning

confidence: 99%

Post-9/11/2001 lung function trajectories by sex and race in World Trade Center-exposed New York City emergency medical service workers

et al. 2016

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Objective To determine whether lung function trajectories after 9/11/2001 (9/11) differed by sex or race/ethnicity in World Trade Center-exposed Fire Department of the City of New York emergency medical service (EMS) workers. Method Serial cross-sectional study of pulmonary function tests (PFTs) taken between 9/11 and 9/10/2015. We used data from routine PFTs (forced expiratory volume in 1 s (FEV1) and FEV1% predicted), conducted at 12–18 month intervals. FEV1 and FEV1% predicted were assessed over time, stratified by sex, and race/ethnicity. We also assessed FEV1 and FEV1% predicted in current, former and never-smokers. Results Among 1817 EMS workers, 334 (18.4%) were women, 979 (53.9%) self-identified as white and 939 (51.6%) were never-smokers. The median follow-up was 13.1 years (IQR 10.5–13.6), and the median number of PFTs per person was 11 (IQR 7–13). After large declines associated with 9/11, there was no discernible recovery in lung function. In analyses limited to never-smokers, the trajectory of decline in adjusted FEV1 and FEV1% predicted was relatively parallel for men and women in the 3 racial/ethnic groups. Similarly, small differences in FEV1 annual decline between groups were not clinically meaningful. Analyses including ever-smokers were essentially the same. Conclusions 14 years after 9/11, most EMS workers continued to demonstrate a lack of lung function recovery. The trajectories of lung function decline, however, were parallel by sex and by race/ethnicity. These findings support the use of routine, serial measures of lung function over time in first responders and demonstrate no sex or racial sensitivity to exposure-related lung function decline.

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Gonadal hormones and oxidative stress interaction differentially affects survival of male and female mice after lungKlebsiella Pneumoniaeinfection

Cited by 44 publications

References 48 publications

Effect of ozone exposure and infection on bronchoalveolar lavage: Sex differences in response patterns

Effect of ozone exposure and infection on bronchoalveolar lavage: Sex differences in response patterns

Understanding the Intersection of Environmental Pollution, Pneumonia, and Inflammation: Does Gender Play a Role?

Post-9/11/2001 lung function trajectories by sex and race in World Trade Center-exposed New York City emergency medical service workers

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