Gonadal influences on behavioral deterioration with aging of male rats

Perez, Juan Manuel Bethencourth; Burunat, Enrique; Arevalo, R.; Rodrı́guez, Manuel

doi:10.1016/0018-506x(89)90035-4

Cited by 5 publications

(1 citation statement)

References 29 publications

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“…& Chambers, 1993). Testosterone exposure throughout life may have a senescence promotor effect as older rats castrated in the neonatal period outperformed sham-operated rats and rats castrated as juveniles on a task of motor coordination (Perez, Burunat, Arevalo, & Rodriguez, 1989). On the other hand, testosterone administration in aged rats increased the biosynthetic activity of vasopressin neurons in the bed nucleus of the stria terminalis (Dobie, Miller, Raskind, & Dorsa, 1992).…”

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Testosterone influences spatial cognition in older men.

Janowsky¹,

Oviatt²,

Orwoll³

1994

Behavioral Neuroscience

454

252

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Testosterone plays a role in the organization of behavior during development. The authors examined whether testosterone could play a maintenance role in behavior as well. In a double-blind manner, verbal and visual memory, spatial cognition, motor speed, cognitive flexibility, and mood in a group of healthy older men who were supplemented for 3 months with testosterone were assessed. The increase in testosterone levels to 150% of baseline levels resulted in a significant enhancement of spatial cognition, but no change in any other cognitive domain was found. Testosterone supplementation influenced the endogenous production of estradiol, and estradiol was found to have an inverse relationship to spatial cognitive performance. These results suggest that testosterone supplementation can modify spatial cognition in older men; however, it is likely that this occurs through testosterone's influence on estrogen.You are only as old as your glands. (Hamilton, 1986, p. 40)

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confidence: 99%