Gonadal sex steroid status and bone health in middle-aged and elderly European men

Vanderschueren, Dirk; Pye, Stephen R.; Venken, Katrien; Borghs, Herman; Gaytant, J.; Huhtaniemi, Ilpo; Adams, Judith E.; Ward, Kate A; Bártfai, György; Casanueva, Felipe F.; Finn, Joseph D.; Forti, Gianni; Giwercman, Aleksander; Han, Tae-Kyung; Kula, Krzysztof; Labrie, Fernand; Lean, Michael E. J.; Pendleton, Neil; Punab, Margus; Silman, Alan J.; Wu, Frederick C. W.; O’Neill, Terence W; Boonen, Steven

doi:10.1007/s00198-009-1144-2

Cited by 37 publications

(31 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We recently reported a similar negative association with bone QUS parameters, even after adjusting for potential confounders, in our cohort (53). Similar findings have also been documented in ageing women (54).…”

Section: Discussionsupporting

confidence: 90%

Influence of bone remodelling rate on quantitative ultrasound parameters at the calcaneus and DXA BMDa of the hip and spine in middle-aged and elderly European men: the European Male Ageing Study (EMAS)

Boonen

Pye

O'Neill

et al. 2011

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: To assess the influence of sex hormones on markers of bone turnover and to explore the association between these markers and bone health in middle-aged and elderly European men. Design: A cross-sectional population-based survey. Methods: Men aged 40-79 years were recruited from population registers in eight European centres. Subjects completed a postal questionnaire which included questions concerning lifestyle and were invited to undergo quantitative ultrasound (QUS) of the calcaneus and to provide a fasting blood sample from which the bone markers serum N-terminal propeptide of type 1 procollagen (P1NP) and crosslinks (b C-terminal cross-linked telopeptide (b-cTX)), total testosterone, total oestradiol (E 2 ), sex hormone-binding globulin (SHBG) and insulin-like growth factor 1 (IGF1) were measured. Dualenergy X-ray absorptiometry (DXA) of the hip and lumbar spine was performed in two centres. Results: A total of 3120, mean age 59.9 years (S.D.Z11.0) were included. After adjustment for centre, age, height, weight, lifestyle factors, season and other hormones, total and free E 2 were negatively associated with b-cTX but not P1NP while SHBG, IGF1 and parathyroid hormone (PTH) were positively associated with both b-cTX and P1NP. Total or free testosterone was not independently associated with either bone marker. After the same adjustments, higher levels of both bone markers were significantly associated with lower QUS parameters and lower DXA-assessed bone density at the total hip and lumbar spine. Conclusions: E 2 , SHBG, IGF1 and PTH contribute significantly to the regulation/rate of bone turnover in middle-aged and older European men. Higher rates of bone remodelling are negatively associated with male bone health.

show abstract

Section: Discussionsupporting

confidence: 90%

Influence of bone remodelling rate on quantitative ultrasound parameters at the calcaneus and DXA BMDa of the hip and spine in middle-aged and elderly European men: the European Male Ageing Study (EMAS)

Boonen

Pye

O'Neill

et al. 2011

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…120 In the EMAS study, however, men with overt hypogonadism (total T<230 ng/dL [8 nml/L]) show worse serum parameters of bone health compared with eugonadal men. 118,121 Probably, T contributes to bone health through its effect on muscle mass (and the consequent mechanical load on bone) and via aromatization to estrogens. 42,48,121 Thus, low circulating levels of T result in parallel in low serum E 2 42,48 .…”

Section: Main Outcomes Of Cohort Studiesmentioning

confidence: 99%

Aging and sex hormones in males

2016

View full text Add to dashboard Cite

Several large cohort studies have disclosed the trajectories of sex steroids changes overtime in men and their clinical significance. In men the slow, physiological decline of serum testosterone (T) with advancing age overlaps with the clinical condition of overt, pathological hypogonadism. In addition, the increasing number of comorbidities, together with the high prevalence of chronic diseases, all further contribute to the decrease of serum T concentrations in the aging male. For all these reasons both the diagnosis of late-onset hypogonadism (LOH) in men and the decision about starting or not T replacement treatment remain challenging. At present, the biochemical finding of T deficiency alone is not sufficient for diagnosing hypogonadism in older men. Coupling hypogonadal symptoms with documented low serum T represents the best strategy to refine the diagnosis of hypogonadism in older men and to avoid unnecessary treatments.

show abstract

“…All fractions of E2 may play a crucial role in the maintenance of bone health in men, more important than T. In middle-aged and elderly men, total and free E2, but not T, blood levels positively correlated with bone health [4]. Aromatase deficiency (a rare autosomal recessive disorder) in young men, despite normal or elevated T levels, results in osteopenia and osteoporosis [5][6][7][8].…”

Section: Rycina 1 Zmiany Wskaźnika Masy Ciała (Bmi) (A) Stężenia Womentioning

confidence: 99%

“…This might be because young men were invited. In the European Male Ageing Study, exploring the relationship between gonadal steroid status and bone health in the older population, the response rate was 45% [4,33]. Any factors influencing participation, however, are unlikely to have influenced the association between hormones and QUS parameters, which are based on an internal comparison of those who participated.…”

Section: Rycina 1 Zmiany Wskaźnika Masy Ciała (Bmi) (A) Stężenia Womentioning

confidence: 99%

“…Studies on individuals with androgen insensitivity support the role of T in maintaining trabecular bone [2], and androgen receptors have been reported in human osteoblasts [3]. However, in a large cohort of middle-aged and elderly men, total and free E2, but not T, blood levels were found to positively correlate with bone health as estimated by quantitative ultrasonography (QUS) at the calcaneus [4]. Longitudinal bone growth ceases by the end of puberty and it is thought to be a result, in both males and females, of the actions of increased pubertal oestrogen concentrations to induce epiphyseal maturation and closure [5][6][7][8].…”

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Wolne i biodostępne frakcje steroidów płciowych mogą wpływać na kości u młodych mężczyzn w zależności od wieku i stężenia estradiolu

Szyska-Skrobot¹,

Marchlewska²,

Walczak-Jędrzejowska³

et al. 2014

Endokrynologia Polska

View full text Add to dashboard Cite

Free and bioavailable fractions of sex steroids may influence bones in young men, depending on age and oestradiol level Wolne i biodostępne frakcje steroidów płciowych mogą wpływać na kości u młodych mężczyzn w zależności od wieku i stężenia estradiolu AbstractIntroduction: Longitudinal bone growth ceases by the end of puberty, and it is thought to be a result, in both sexes, of increased pubertal oestrogen serum concentrations. Since peak bone mass is achieved by the third decade of life or later, the aim of this study was to relate sex steroid hormones and sex hormone binding globulin (SHBG) levels to bone quality in men during their third and fourth decades of life. Material and methods: Eighty men, healthy volunteers aged between 18 and 39 years, were subjected to an interviewer-administered questionnaire, body mass index (BMI) measurement, blood sample and calcaneal quantitative ultrasound (QUS) (Hologic-SAHARA). Blood was assessed for testosterone (T), oestradiol (E2), dehydroepiandrosterone sulfate (DHEAS), SHBG, luteinising hormone (LH) and follicle stimulating hormone (FSH). Free and bioavailable T and E2 levels were calculated knowing SHBG and albumin levels. Results: While T, E2, DHEAS, LH and FSH levels were not related, free and bioavailable fractions of T and E2 were positively associated with QUS readings. SHBG level was associated negatively. After dichotomisation for age, the associations remained significant only for younger subjects (18-30 years, n = 47). After adjustment for other co-variants, only SHBG in younger subjects retained its negative association with QUS. Older subjects (31-39 years, n = 33) revealed higher BMI and lower serum concentrations of total (-17 %), free (-18.5%) and bioavailable (-22.5%) levels of E2 than younger subjects. Conclusion: Free and bioavailable fractions of sex steroids may influence bones in young men, depending on age and E2 level.

show abstract

Gonadal sex steroid status and bone health in middle-aged and elderly European men

Abstract: Higher free and total E(2) are associated with bone health not only among the elderly but also middle-aged European men.

Cited by 37 publications

References 48 publications

Influence of bone remodelling rate on quantitative ultrasound parameters at the calcaneus and DXA BMDa of the hip and spine in middle-aged and elderly European men: the European Male Ageing Study (EMAS)

Influence of bone remodelling rate on quantitative ultrasound parameters at the calcaneus and DXA BMDa of the hip and spine in middle-aged and elderly European men: the European Male Ageing Study (EMAS)

Aging and sex hormones in males

Wolne i biodostępne frakcje steroidów płciowych mogą wpływać na kości u młodych mężczyzn w zależności od wieku i stężenia estradiolu

Contact Info

Product

Resources

About