Gonadal Steroid Action

McKenna, Neil J.

doi:10.1016/b978-0-12-397175-3.00009-0

Cited by 6 publications

(2 citation statements)

References 189 publications

(106 reference statements)

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“…These are just a few of the relatively recent developments that have elucidated how steroids affect cells and specifically brain function by modulating gene transcription. More extensive reviews of the current state of the art have been published and it is clearly not the purpose of this short assay to cover this field exhaustively (see namely (Etgen and Pfaff, 2009b; McKenna, 2016)). However, the more we learn, the more we realize how little we know.…”

Section: Genomic Action Of Steroids: the Last 50 Yearsmentioning

confidence: 99%

Steroids and the brain: 50 years of research, conceptual shifts and the ascent of non-classical and membrane-initiated actions

Balthazart

Choleris

Remage‐Healey

2018

Hormones and Behavior

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This brief commentary reviews key steps in the history of steroid endocrinology that have resulted in important conceptual shifts. Our understanding of the "Fast Effects of Steroids" now reflect substantial progress, including the major concept that steroids act rapidly on a variety of physiological and behavioral responses, via mechanisms that are too fast to be fully accounted for by classical receptor-dependent regulation of gene transcription. Several so-called 'non-classical' mechanisms have been identified and include binding to membrane receptors and regulating non genomic signaling cascades. We survey the discovery of steroids, the initial characterization of their intracellular receptors, key progress in the understanding of the genomic effects of steroids and then the progressive discovery of the rapid non-classical and membrane-initiated actions of steroids. Foundational discoveries about brain steroid synthesis in neural processes and terminals has converged with emerging evidence for the rapid actions of steroids on brain and behavior. Had the rapid effects of steroids in the central nervous system been discovered first, these molecules would likely now be considered as a class of neurotransmitter.

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Section: Genomic Action Of Steroids: the Last 50 Yearsmentioning

confidence: 99%

Steroids and the brain: 50 years of research, conceptual shifts and the ascent of non-classical and membrane-initiated actions

Balthazart

Choleris

Remage‐Healey

2018

Hormones and Behavior

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“…In animal reproduction, synthesis of sex steroid hormones is one of the most primary processes ( 15 ) . Steroid hormones activate the gonadal development and play important regulating roles all through the reproductive period, even including ovulation ( 16 ) .…”

mentioning

confidence: 99%

Effects of different dietary DHA:EPA ratios on gonadal steroidogenesis in the marine teleost, tongue sole (Cynoglossus semilaevis)

Cao

Wei

et al. 2017

Br J Nutr

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The present study was conducted to investigate the effects of dietary DHA and EPA on gonadal steroidogenesis in mature females and males, with a feeding trial on tongue sole, a typical marine teleost with sexual dimorphism. Three experimental diets differing basically in DHA:EPA ratio, that is, 0·68 (diet D:E-0·68), 1·09 (D:E-1·09) and 2·05 (D:E-2·05), were randomly assigned to nine tanks of 3-year-old tongue sole (ten females and fifteen males in each tank). The feeding trail lasted for 90 d before and during the spawning season. Fish were reared in a flowing seawater system and fed to apparent satiation twice daily. Compared with diet D:E-0·68, diet D:E-1·09 significantly enhanced the oestradiol production in females, whereas diet D:E-2·05 significantly enhanced the testosterone production in males. In ovaries, diet D:E-1·09 induced highest mRNA expression of follicle-stimulating hormone receptor (FSHR), steroidogenic acute regulatory protein, 17α-hydroxylase (P450c17) and 3β-hydroxysteroid dehydrogenase (3β-HSD). In testes, diet 2·05 resulted in highest mRNA expression of FSHR, cholesterol side-chain cleavage enzyme, P450c17 and 3β-HSD. Fatty acid profiles in fish tissues reflected closely those of diets. Female fish had more gonadal EPA content but less DHA content than male fish, whereas there was a reverse observation in liver. In conclusion, the dietary DHA:EPA ratio, possibly combined with the dietary EPA:arachidonic acid ratio, differentially regulated sex steroid hormone synthesis in mature female and male tongue soles. Females seemed to require more EPA but less DHA for the gonadal steroidogenesis than males. The results are beneficial to sex-specific nutritive strategies in domestic teleost.

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The epigenetic impacts of endocrine disruptors on female reproduction across generations†

Rattan

Flaws

2019

Biology of Reproduction

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Humans and animals are repeatedly exposed to endocrine disruptors, many of which are ubiquitous in the environment. Endocrine disruptors interfere with hormone action; thus, causing non-monotonic dose responses that are atypical of standard toxicant exposures. The female reproductive system is particularly susceptible to the effects of endocrine disruptors. Likewise, exposures to endocrine disruptors during developmental periods are particularly concerning because programming during development can be adversely impacted by hormone level changes. Subsequently, developing reproductive tissues can be predisposed to diseases in adulthood and these diseases can be passed down to future generations. The mechanisms of action by which endocrine disruptors cause disease transmission to future generations are thought to include epigenetic modifications. This review highlights the effects of endocrine disruptors on the female reproductive system, with an emphasis on the multi- and transgenerational epigenetic effects of these exposures.

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Gonadal Steroid Action

Cited by 6 publications

References 189 publications

Steroids and the brain: 50 years of research, conceptual shifts and the ascent of non-classical and membrane-initiated actions

Steroids and the brain: 50 years of research, conceptual shifts and the ascent of non-classical and membrane-initiated actions

Effects of different dietary DHA:EPA ratios on gonadal steroidogenesis in the marine teleost, tongue sole (Cynoglossus semilaevis)

The epigenetic impacts of endocrine disruptors on female reproduction across generations†

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