Gonadal tumor and H-Y antigen in 46,XY pure gonadal dysgenesis

Amice, V.; Amice, J.; Bercovici, J. P.; Rivière, D; Corolleur, Marie-Joséa

doi:10.1002/1097-0142(19860401)57:7<1313::aid-cncr2820570710>3.0.co;2-k

Cited by 19 publications

(8 citation statements)

References 19 publications

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“…Uehara et al ., and Amice showed that SRY may play a formation of gonadal tumors, especially dysgerminoma in Swyer syndrome [20,21]. However intra abdominal gonads should be removed as early in life as possible because of the known risk of tumor development [2].…”

Section: Discussionmentioning

confidence: 99%

Dysgerminoma in three patients with Swyer syndrome

Behtash¹,

Zarchi²

2007

World J Surg Onc

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Section: Discussionmentioning

confidence: 99%

Dysgerminoma in three patients with Swyer syndrome

Behtash¹,

Zarchi²

2007

World J Surg Onc

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“…1 As with other disorders of sex development, patients with Swyer syndrome are at risk of gonadoblastoma and malignant transformation of the dysplastic gonads. 2,3 The affected individuals are phenotypically female with normal external genitalia, and normal or hypoplastic Mullerian structures. They are almost always diagnosed when they present with primary amenorrhea and/or delayed puberty.…”

mentioning

confidence: 79%

Ovarian Choriocarcinoma as the First Manifestation of 46,XY Pure Gonadal Dysgenesis

Lee¹,

Fong²

2011

Journal of Pediatric Hematology/Oncology

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We report a case of 46,XY pure gonadal dysgenesis (Swyer syndrome) in a phenotypically normal 12-year-old girl with a history of vaginal bleeding and early breast development, with ovarian choriocarcinoma as the first manifestation. The clues leading to the diagnosis included the failure to establish any relationship between normal menstrual cycles postoperatively and a small remaining contralateral ovary. The correct diagnosis is important for cancer prophylaxis and hormonal replacement therapy. Prepubertal and peripubertal girls presenting with gonadal germ cell tumors should be carefully evaluated for the possibility of underlying gonadal dysgenesis. A history of vaginal bleeding or early signs of puberty does not exclude the diagnosis.

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“…[25] In the 1880s, it was elucidated that the presence of macromolecules differentially in the normal and tumor tissue microenvironments. [26] Passive accumulation of drug-polymer conjugates or drug-containing liposomes within tumors may reflect high vascular permeability, which is the EPR effect. Studies have found that NPs with a size of 50-200 nm are more conducive to accumulation in tumor tissues to achieve passive targeting.…”

Section: Passive Targetingmentioning

confidence: 99%

Cancer Immunotherapy Elicited by Immunogenic Cell Death Based on Smart Nanomaterials

et al. 2023

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Cancer immunotherapy has been a revolutionary cancer treatment modality because it can not only eliminate primary tumors but also prevent metastases and recurrent tumors. Immunogenic cell death (ICD) induced by various treatment modalities, including chemotherapy, phototherapy, and radiotherapy, converts dead cancer cells into therapeutic vaccines, eliciting a systemic antigen‐specific antitumor. However, the outcome effect of cancer immunotherapy induced by ICD has been limited due to the low accumulation efficiency of ICD inducers in the tumor site and concomitant damage to normal tissues. The boom in smart nanomaterials is conducive to overcoming these hurdles owing to their virtues of good stability, targeted lesion site, high bioavailability, on‐demand release, and good biocompatibility. Herein, the design of targeted nanomaterials, various ICD inducers, and the applications of nanomaterials responsive to different stimuli, including pH, enzymes, reactive oxygen species, or dual responses are summarized. Furthermore, the prospect and challenges are briefly outlined to provide reference and inspiration for designing novel smart nanomaterials for immunotherapy induced by ICD.

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Gonadal tumor and H-Y antigen in 46,XY pure gonadal dysgenesis

Cited by 19 publications

References 19 publications

Dysgerminoma in three patients with Swyer syndrome

Dysgerminoma in three patients with Swyer syndrome

Ovarian Choriocarcinoma as the First Manifestation of 46,XY Pure Gonadal Dysgenesis

Cancer Immunotherapy Elicited by Immunogenic Cell Death Based on Smart Nanomaterials

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