Gonadal white adipose tissue is important for gametogenesis in mice through maintenance of local metabolic and immune niches

Yang, Chaofan; Liu, Wen; Wang, Hai-Quan; Zhang, Jia-Le; Li, Kang; Diao, Zongli; Yue, Qiuling; Yan, Guijun; Li, Chao‐Jun; Sun, Haixiang

doi:10.1016/j.jbc.2022.101818

Cited by 8 publications

(6 citation statements)

References 40 publications

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“…A group of other authors believes that gonadal white adipose tissue may regulate gametogenesis by modulating neuroendocrine signaling. [16,17,31].…”

Section: Discussionmentioning

confidence: 99%

The greater omentum and similar serous formations of testis in male white rats

Гринь¹,

Kostylenko²,

Maksymenko³

2023

Folia Morphol

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“…A group of other authors believes that gonadal white adipose tissue may regulate gametogenesis by modulating neuroendocrine signaling. [16,17,31].…”

Section: Discussionmentioning

confidence: 99%

The greater omentum and similar serous formations of testis in male white rats

Гринь¹,

Kostylenko²,

Maksymenko³

2023

Folia Morphol

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“…An altered metabolic microenvironment (lack of homeostasis) in the testis affects spermatogenesis and impairs male fertility (Yang et al, 2022). The maintenance of the testis microenvironment is based on the metabolic coupling between Sertoli cells and germ cells as these cells provide the energy and material basis for spermatogenesis (Enders & Millette, 1988; Holembowski et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Our previous study found that alteration of the metabolic microenvironment of the testis has an important effect on spermatogenesis. After removal of epididymal white adipose tissue in mice, the disruption of the glycerophospholipid metabolism pathway in the mouse testis results in abnormal spermatogenesis (Yang et al, 2022). With aging, the male reproductive system undergoes a series of changes as the metabolic environment suffers disruption.…”

mentioning

confidence: 99%

Mevalonate pathway and male reproductive aging

Zhang,

Lv,

Yang

et al. 2023

Molecular Reproduction Devel

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Male fertility declines with age. The mevalonate pathway, through which cholesterol and nonsteroidal isoprenoids are synthesized, plays key role in metabolic processes and is an essential pathway for cholesterol production and protein prenylation. Male reproductive aging is accompanied by dramatic changes in the metabolic microenvironment of the testis. Since the mevalonate pathway has an important role in spermatogenesis, we attempted to explore the association between male reproductive aging and the mevalonate pathway to explain the mechanism of male reproductive aging. Alterations in the mevalonate pathway may affect male reproductive aging by decreasing cholesterol synthesis and altering testis protein prenylation. Decreased cholesterol levels affect cholesterol modification, testosterone production, and remodeling of germ cell membranes. Aging‐related metabolic disorders also affect the metabolic coupling between somatic cells and spermatogenic cells, leading to male fertility decline. Therefore, we hypothesized that alterations in the mevalonate pathway represent one of the metabolic causes of reproductive aging.

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“…The discriminant metabolites from univariate analysis in both type of AT are different, and although their statistical weight is low, this suggests an interesting difference in response between eAT and rAT. It may be related to the fact that eAT has been confirmed to be an important regulator of the reproductive system in mice, 40 where POPs have also been shown to cause reproductive disorders. 41 In the following we will discuss metabolic modulations in the liver, brain, and AT by families of metabolites that participate in common metabolic pathways.…”

Section: F I G U R Ementioning

confidence: 99%

NMR metabolomics study of chronic low‐dose exposure to a cocktail of persistent organic pollutants

Lucas‐Torres,

Caradeuc,

Prieur

et al. 2023

NMR in Biomedicine

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Nowadays, exposure to endocrine‐disrupting chemicals (EDCs), including persistent organic pollutants (POPs), is one of the most critical threats to public health. EDCs are chemicals that mimic, block, or interfere with hormones in the body's endocrine system and have been associated with a wide range of health issues. This innovative, untargeted metabolomics study investigates chronic low‐dose internal exposure to a cocktail of POPs on multiple tissues that are known to accumulate these lipophilic compounds. Interestingly, the metabolic response differs among selected tissues/organs in mice. In the liver, we observed a dynamic effect according to the exposure time and the doses of POPs. In the brain tissue, the situation is the opposite, leading to the conclusion that the presence of POPs immediately gives a saturated effect that is independent of the dose and the duration of exposure studied. By contrast, for the adipose tissues, nearly no effect is observed. This metabolic profiling leads to a holistic and dynamic overview of the main metabolic pathways impacted in lipophilic tissues by a cocktail of POPs.

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Gonadal white adipose tissue is important for gametogenesis in mice through maintenance of local metabolic and immune niches

Cited by 8 publications

References 40 publications

The greater omentum and similar serous formations of testis in male white rats

The greater omentum and similar serous formations of testis in male white rats

Mevalonate pathway and male reproductive aging

NMR metabolomics study of chronic low‐dose exposure to a cocktail of persistent organic pollutants

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