Gonadoblastoma in the Ovaries of a Lesser Galago (Galago senegalensis braccatus)

Rovira, Armando R. Irizarry; Lynch, S. V.; David, M; Vara, J.A. Ramos

doi:10.1016/j.jcpa.2012.01.007

Cited by 4 publications

(3 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Combinations of more than one of the three traditional lineages have been described in ovarian lesions of domestic animals [7–9]; however, these must be distinguished from two distinct neoplastic entities, collision tumours and tissue histological variations within a single tumour [10]. Ovarian tumours composed of a mixture of germ cells and sex cord-stromal cells are rare in both humans and animals [7, 11, 12]. According to the human World Health Organization (WHO) classification of tumours of the genital system, these lesions are subclassified into gonadoblastoma (GB) or mixed germ cell-sex cord-stromal tumour (MGCSCST) [12].…”

Section: Introductionmentioning

confidence: 99%

“…Mixed tumours histologically resembling human GB have been rarely described in veterinary literature, most occurring in the testes instead of ovaries [7, 11, 14–16]. To the best of our knowledge, only two cases arising from the ovary were reported, one consisting of a mixed dysgerminoma/granulosa cell tumour in a bitch [7] and another of a bilateral GB in a female Lesser Galago [11]. The present communication describes an unprecedented case of ovarian GB with proliferation of dysgerminoma and sex cord-stromal neoplastic components, in a phenotypically and cytogenetically normal bitch.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Canine ovarian gonadoblastoma with dysgerminoma overgrowth: a case study and literature review

et al. 2019

View full text Add to dashboard Cite

Background Gonadoblastoma (GB) is a rare mixed germ cell-sex cord-stromal tumour, first described in humans, commonly found in dysgenetic gonads of intersex patients that have a Y chromosome. However, this entity in not recognized in the WHO classification of tumours of genital system of domestic animals. Herein, we describe a case of ovarian gonadoblastoma with proliferation of dysgerminoma and sex cord-stromal tumour components, in a phenotypically and cytogenetically normal bitch. Case presentation A 17-year-old cross-breed bitch had a firm, grey-white multinodular mass in the left ovary. The tumour was submitted to histopathological examination and Y chromosome detected through karyotype analysis and PCR studies. Microscopically, the ovary was almost replaced by an irregular neoplasm composed of three distinct, intermixed elements: dysgerminoma, mixed germ cell-sex cord-stromal tumour resembling human GB and a proliferative sex cord-stromal tumour component. The germ cells of gonadoblastoma and dysgerminoma components were immunoreactive for c-KIT. Sex cord-stromal cells of gonadoblastoma were immunoreactive for α-inhibin. The sex cord-stromal tumour was immunoreactive for AE1/AE3, occasionally for α-inhibin and negative for epithelial membrane antigen (EMA). The karyotype was 78, XX and PCR analysis confirmed the absence of the Y chromosome. Conclusion Based on these findings, a diagnosis of gonadoblastoma with proliferation of dysgerminoma and sex cord-stromal tumour was made. This is the first case of ovarian gonadoblastoma in a female dog.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Canine ovarian gonadoblastoma with dysgerminoma overgrowth: a case study and literature review

et al. 2019

View full text Add to dashboard Cite

show abstract

“…In humans, gonadoblastomas consist of discrete nests separated by fibrous stroma containing Call-Exner bodies or calcified foci [ 15 ]. Though gonadoblastomas are not included in the World Health Organization classification of tumors that occur in domestic animals, detection of gonadoblastomas has been reported in two canines, two rabbits and in a lesser galago [ 7 , 8 , 16 ]. On the other hand, MGSCTs typically consist of diffuse admixed proliferation of two cell types, and Call-Exner bodies are usually absent [ 17 ].…”

mentioning

confidence: 99%

Mixed germ cell-sex cord-stromal tumor with a concurrent interstitial cell tumor in a ferret

Inoue

Yonemaru

Yanai

et al. 2015

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

A 5-year-old male ferret presented with an enlarged canalicular testis in the left inguinal region. Microscopically, the enlarged testis consisted of a diffuse intimately admixed proliferation of c-kit-positive germ cell-like and Wilms tumor-1 protein-positive Sertoli cell-like components, but no Call-Exner body was detected. In addition, the compact proliferation of steroidogenic acute regulatory protein-intense positive interstitial cells was identified in a separate peripheral area of the mass. Based on histopathological and immunohistochemical findings, the tumor was diagnosed as a mixed germ cell-sex cord-stromal tumor with a concurrent interstitial cell tumor.

show abstract

Nonhuman Primates

Suckow¹,

Scholz²,

Barnhart³

2020

Veterinary Cytology

View full text Add to dashboard Cite

Gonadoblastoma in the Ovaries of a Lesser Galago (Galago senegalensis braccatus)

Cited by 4 publications

References 20 publications

Canine ovarian gonadoblastoma with dysgerminoma overgrowth: a case study and literature review

Canine ovarian gonadoblastoma with dysgerminoma overgrowth: a case study and literature review

Mixed germ cell-sex cord-stromal tumor with a concurrent interstitial cell tumor in a ferret

Nonhuman Primates

Contact Info

Product

Resources

About