Gonadotrophin and prolactin secretory dynamics in girls with normal puberty, idiopathic precocious puberty and precocious puberty due to hypothalamic hamartoma

Uriarte, M. Mercedes; Klein, Karen Oerter; Barnes, Kevin M.; Pescovitz, Ora Hirsch; Loriaux, D. Lynn; Cutler, Gordon B.

doi:10.1046/j.1365-2265.1998.00518.x

Cited by 7 publications

(4 citation statements)

References 37 publications

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“…A later report, however, has found that hamartoma cells contain TGFa-, but not GnRH-expressing cells (28). In any case, results of the GnRH tests are in line with previous data consistent with a GnRH pulse generator-dependent precocious puberty (29). A particular feature of this precocious puberty is that the prepubertal hiatus in the activity of the GnRH pulse generator is absent.…”

Section: Discussionsupporting

confidence: 89%

Precocious puberty in children with tumours of the suprasellar and pineal areas: Organic central precocious puberty

Rivarola¹,

Belgorosky²,

Mendilaharzu³

et al. 2001

Acta Paediatrica

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Section: Discussionsupporting

confidence: 89%

Precocious puberty in children with tumours of the suprasellar and pineal areas: Organic central precocious puberty

Rivarola¹,

Belgorosky²,

Mendilaharzu³

et al. 2001

Acta Paediatrica

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“…Together with other findings concerning the role and function of glial cells (Ojeda, 1994) these observations open the possibility that precocious puberty in hamartoma patients may be caused by changes in glial cell activity and by the influence of glial cell products on hypothalamic GnRH neurons (Jung et al, 1999). In addition, there are differences in the pituitary response to exogenous GnRH between patients with hypothalamic hamartoma and those with idiopathic precocious puberty suggesting different changes in the neuroendocrine regulation (Uriarte et al, 1998). Magnetic resonance imaging (MRI) is of particular importance in the diagnosis of hypothalamic hamartomas since histological examination will not be carried out in most patients.…”

Section: Hypothalamic Hamartomamentioning

confidence: 51%

Pathogenesis and epidemiology of precocious puberty. Effects of exogenous oestrogens

Partsch

Sippell

2001

APMIS

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Precocious puberty is generally defined as the appearance of secondary sex characteristics before age 8 years in girls (or menarche before age 9 years) and before 9 years in boys. The overall incidence of sexual precocity is estimated to be 1:5000 to 1:lO 000 children. The female-to-male ratio is -1O:l. In addition to the psychosocial disturbances associated with precocious puberty, the premature pubertal growth spurt (with less time for prepubertal growth) and the accelerated bone maturation result in reduced adult height. Precocious puberty may be gonadotrophindependent [i.e. of central origin with premature activation of the gonadotrophin-releasing hormone (GnRH) pulse generator] or gonadotrophin-independent (i.e. peripheral where the GnRH pulse generator is suppressed). This can be determined by GnRH testing. The pathophysiology is the basis for different diagnostic and therapeutic strategies, i.e. in the first case a stimulated LWFSH ratio >1 and suppressive treatment with GnRH agonists (e.g. in hypothalamic hamartoma), and in the second decreased gonadotrophins and removal or suppression of the endogenous or exogenous sex steroid source (e.g. congenital adrenal hyperplasia). While several cases of gonadotrophin-independent precocious puberty due to oestrogen exposure via the transdermal, oral, or inhalative route have been reported, no case is known with the development of subsequent secondary central precocious puberty. Food contamination with oestrogens is theoretically possible, but would most probably be sporadic and, thus, would not lead to precocious puberty. As steroid hormones in meat production are banned in the European Union, no data on the impact of environmental oestrogenic substances on human maturation are currently available. In conclusion, the risk for children to develop precocious puberty through exposure to oestrogens (or androgens) in the environment or in food is very low. Nevertheless, studies of the effects of defined environmental oestrogenic substances on the human reproductive system and on pubertal development are warranted.

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“…Prolactinoma is rare in children and prolactin dynamics has been investigated in one study where prolactin secretion was observed to be similar among girls with hypothalamic hamartoma, idiopathic precocious puberty and normal puberty [23]. Prolactinoma is rare in children and prolactin dynamics has been investigated in one study where prolactin secretion was observed to be similar among girls with hypothalamic hamartoma, idiopathic precocious puberty and normal puberty [23].…”

Section: Discussionmentioning

confidence: 99%

“…We also report a girl with breast development only who was found to have a pituitary microadenoma associated with hyperprolacinaemia. Prolactinoma is rare in children and prolactin dynamics has been investigated in one study where prolactin secretion was observed to be similar among girls with hypothalamic hamartoma, idiopathic precocious puberty and normal puberty [23].…”

Section: Discussionmentioning

confidence: 99%

Precocious puberty at an endocrine centre in Jordan

Taher¹,

Ajlouni²,

Hamamy³

et al. 2004

Eur J Clin Investigation

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Gonadotrophin and prolactin secretory dynamics in girls with normal puberty, idiopathic precocious puberty and precocious puberty due to hypothalamic hamartoma

Cited by 7 publications

References 37 publications

Precocious puberty in children with tumours of the suprasellar and pineal areas: Organic central precocious puberty

Precocious puberty in children with tumours of the suprasellar and pineal areas: Organic central precocious puberty

Pathogenesis and epidemiology of precocious puberty. Effects of exogenous oestrogens

Precocious puberty at an endocrine centre in Jordan

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