Gonadotrophins versus clomifene citrate with or without intrauterine insemination in women with normogonadotropic anovulation and clomifene failure (M-OVIN): a randomised, two-by-two factorial trial

Weiss, N S; Nahuis, Marleen; Bordewijk, Esmée M; Oosterhuis, Jurjen G E; Smeenk, J.M.J.; Hoek, Annemieke; Broekmans, Frank J.; Fleischer, Kathrin; Bruin, Jan Peter de; Kaaijk, Eugenie M.; Laven, Joop S.E.; Hendriks, Dave J.; Gerards, Marie H.; Rooij, Ilse A.J. van; Bourdrez, Petra; Gianotten, Judith; Koks, Carolien A.M.; Lambalk, Cornelis B.; Hompes, Peter G.A.; Veen, Fulco van der; Mol, Ben Willem J.; Wely, Madelon van

doi:10.1016/s0140-6736(17)33308-1

Cited by 25 publications

(8 citation statements)

References 23 publications

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“…It is envisioned that the hydrogen bonds between the enriched -OH, -NH 2 , C]O/CONH 2 groups in CDs and the carboxyl/ hydroxyl groups in CC, as well as the polar interactions between them form stable electrons donor-acceptor adducts, the efficient energy transfer statically quenches the uorescence of CDs. In the case of static quenching process, the number of binding site (n) and the binding constant (K) can be obtained according to eqn (2) (Fig. 10b)…”

Section: Fluorescence Quenching Mechanismmentioning

confidence: 99%

“…1) is the rst and the most widely used pharmaceutical capable of promoting ovulation in female patients with polycystic ovary syndrome and therefore treating infertility. 1,2 However, a lot of clinical reports have shown that an excessive dosage of CC in the human body also causes ovarian hyperstimulation syndrome and luteinized unruptured follicle syndrome. Hence, the sensitive and reliable monitoring of CC is crucial in the clinic.…”

Section: Introductionmentioning

confidence: 99%

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Highly fluorescent carbon dots as an efficient nanoprobe for detection of clomifene citrate

et al. 2019

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Section: Fluorescence Quenching Mechanismmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Highly fluorescent carbon dots as an efficient nanoprobe for detection of clomifene citrate

et al. 2019

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“…A recently published multi‐centre Dutch RCT compared gonadotrophins with timed intercourse or intrauterine insemination (IUI) versus clomiphene citrate with timed intercourse or IUI over six cycles in 666 infertile WHO Group 2 anovulatory women with CCF and found a higher live‐birth rate (52% vs 41%; relative risk 1.24; 95% CI 1.05–1.46; P = 0.0124) and reduced time to conception leading to live birth (5.0 vs 5.5 months; P = 0.028) favouring gonadotrophins and the addition of IUI did not increase live births compared with timed intercourse. There was no evidence of a difference in multiple pregnancy rates …”

Section: Pharmaceutical Ovulation Induction Treatmentsmentioning

confidence: 92%

A brief update on the evidence supporting the treatment of infertility in polycystic ovary syndrome

Costello

Misso

Balen

et al. 2019

Aust NZ J Obst Gynaeco

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Background: Polycystic ovary syndrome (PCOS) is complex with reproductive, metabolic and psychological features. Infertility is a prevalent presenting feature of PCOS with approximately 75% of these women suffering infertility due to anovulation, making PCOS by far the most common cause of anovulatory infertility.Previous guidelines either lacked rigorous evidence-based processes, did not engage consumer and international multidisciplinary perspectives, or were outdated. Aims: This review paper aims to provide a brief update on the best available and most current research evidence supporting the treatment of PCOS which informed the recommendations in the assessment and treatment of infertility section of the international evidence-based guideline on PCOS 2018.

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“…Women should also be advised if the use of such agents is off-label (though permitted) in countries where this is the case 145 . Women who have achieved regular ovulation with oral induction agents can continue this treatment for up to 12 months, as pregnancy and complication rates are acceptable for this time period 151 . However, prolonged use of ovulation induction agents should be avoided owing to low success rates 145 A second-line treatment for women who fail to respond to oral induction agents is gonadotrophins, which are injectable drugs 152 , .…”

Section: [H2] Ovulation Disordersmentioning

confidence: 99%

Female subfertility

2019

Nat Rev Dis Primers

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Subfertility is common, and affects one in six couples, half of whom lack an explanation for their delay in conceiving. Developments in the diagnosis and treatment of subfertility over the past 50 years have been truly remarkable. Indeed, current generations of couples with subfertility are more fortunate than previous generations as they have many more opportunities to become parents. The timely access to effective treatment for subfertility is important, as many couples have a narrow window of opportunity before the age-related effects of subfertility limit the likelihood of success. Assisted reproduction can overcome the barriers to fertility caused by tubal disease and low sperm counts, but little progress has been made in reducing the effect of increasing age on ovarian function. The next 5-10 years will likely see further increases in birth rates in women with subfertility, greater awareness of lifestyle factors and possible refinement of current assisted reproduction techniques and development of new ones. Such progress will bring challenging questions regarding the potential benefits and harms of treatments involving germ-cell manipulation, artificial gametes, genetic screening of embryos, and gene editing of embryos. We hope to see a major increase in fertility awareness, access to safe and cost-effective fertility care in low-income countries, and a reduction in the current disparity of access to fertility care.

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Gonadotrophins versus clomifene citrate with or without intrauterine insemination in women with normogonadotropic anovulation and clomifene failure (M-OVIN): a randomised, two-by-two factorial trial

Abstract: The Netherlands Organization for Health Research and Development.

Cited by 25 publications

References 23 publications

Highly fluorescent carbon dots as an efficient nanoprobe for detection of clomifene citrate

Highly fluorescent carbon dots as an efficient nanoprobe for detection of clomifene citrate

A brief update on the evidence supporting the treatment of infertility in polycystic ovary syndrome

Female subfertility

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