Gonadotropin-releasing hormone agonist trigger in oocyte donors co-treated with a gonadotropin-releasing hormone antagonist: a dose-finding study

Vuong, Lan N; Ho, Min; Ha, Tan Duc; Phung, H T; Huynh, Gia Bao; Humaıdan, Peter

doi:10.1016/j.fertnstert.2015.10.014

Cited by 50 publications

(55 citation statements)

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“…In addition, patient characteristics for the 10 women in each group who underwent gene profiling were similar to those of the total study population ( Table 1). The effects of the different triptorelin doses on oocyte and embryo outcomes have been reported previously [6]. There were no significant differences between women treated with triptorelin 0.2, 0.3 or 0.4 mg as regards the number of MII oocytes, cleavage rates and the number of top-quality embryos.…”

Section: Resultsmentioning

confidence: 56%

“…This study was based on a previous randomised trial [6]. Sample size was calculated based on the primary endpoint in the main trial (i.e., determining non-inferiority for the number of MII oocytes in the three different triptorelin dosage groups).…”

Section: Discussionmentioning

confidence: 99%

“…The Institutional Review Board (IRB) and Ethics Committee approved the study protocol on 21 July 2014 (IRB reference number: NCKH/CGRH_01_2014, and Clinicaltrial.gov registration: NCT02208986). Primary outcome results have been published previously [6].…”

Section: Methodsmentioning

confidence: 99%

“…However, the results of a recent randomised, investigator-blinded study showed that there were no significant differences between triptorelin doses of 0.2, 0.3 and 0.4 mg when used for triggering of final oocyte maturation in oocyte donors as regards the number of mature oocytes, top-quality embryos, ovarian volume and luteal phase duration [6]. In addition, there were practically no between-group differences in serum concentrations of LH, follicle-stimulating hormone (FSH), oestradiol and progesterone during the follicular and early luteal phases [6].…”

Section: Introductionmentioning

confidence: 99%

“…To further assess the comparability of different triptorelin doses used for trigger [6], the present study (NCT02208986) analysed steroid profiles in FF, and cumulus cell and mural granulosa cells gene expression profiles in GnRH antagonist co-treated women, randomised to three different GnRHa trigger doses.…”

Section: Introductionmentioning

confidence: 99%

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Effect of GnRHa ovulation trigger dose on follicular fluid characteristics and granulosa cell gene expression profiles

Vuong

et al. 2017

J Assist Reprod Genet

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Purpose A recent dose-finding study showed no significant differences in number of mature oocytes, embryos and topquality embryos when triptorelin doses of 0.2, 0.3 or 0.4 mg were used to trigger final oocyte maturation in oocyte donors co-treated with a gonadotropin-releasing hormone (GnRH) antagonist. This analysis investigated whether triptorelin dosing for triggering final oocyte maturation in oocyte donors induced differences in follicular fluid (FF) hormone levels and granulosa cell gene expression. Methods This single-centre, randomised, parallel, investigatorblinded trial was conducted in oocyte donors undergoing a single stimulation cycle at IVFMD, My Duc Hospital, Ho Chi Minh City, Vietnam, from August 2014 to March 2015.A total of 165 women aged 18-35 years with body mass index <28 kg/m 2 , anti-Müllerian hormone >1.25 ng/mL, and antral follicle count ≥6 were randomised to three different triptorelin doses for trigger. The main outcome was concentration of steroid hormones in FF collected from the first punctured follicle on each side. Moreover, luteinising hormone receptor (LHR), 3β-hydroxy-steroid-dehydrogenase (3ßHSD) and inhibin-Ba (INHB-A) gene expression in cumulus and mural granulosa cells were investigated in a subset of women from each group. Results Progesterone and oestradiol levels in FF did not differ significantly by trigger doses; findings were similar for 3βHSD, LHR and INHB-A gene expression in both cumulus and mural granulosa cells. Conclusions In women co-treated with a GnRH antagonist, no significant differences in FF steroid levels and granulosa cell gene expression were seen when different triptorelin doses were used to trigger final oocyte maturation.

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Section: Resultsmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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