Delamination of lower continental lithosphere is known to have occurred under different tectonic settings. However, its fate in the mantle is poorly understood. By analyzing global seismic models, we find that most of likely lithosphere that delaminated during the Cenozoic and Mesozoic is preserved in the mantle transition zone, especially beneath North America and Africa. Numerical experiments indicates that delaminated lithosphere can remain stagnant in the mantle transition zone for tens of millions of years, followed by its potential sinking into the lower mantle or re‐rising to shallower depths depending on its density, the Clapeyron slope of the spinel‐to‐post‐spinel phase change and increase in mantle viscosity at ∼660–1,000 km depths. Re‐ascent occurs when delaminated lithosphere is reheated so that its effective density becomes lower than its surrounding ambient mantle after ∼100 Myr. Delaminated fragments can also potentially be mobilized by underlying global mantle flow to move horizontally away from plume regions.