Gonorrhea treated with oxytetracycline

A survey of problems in the antibiotic treatment of gonorrhoea. With special reference to South-East Asia.

“…Also most of the published information refers to male patients. Females need more prolonged and intensive treatment (Shapiro and Lentz, 1967), given for approximately double the time required by males. INJECTABLE PENICILLINS (Table XXXI) Even in areas with highly resistant gonococci, satisfactory cures can still be obtained with single injections of crystalline benzyl penicillin G in high doses with probenecid, while repeated injections of this or of procaine penicillin can be expected to produce levels in excess of the MIC of the least sensitive strains if given in sufficient amounts and with sufficient frequency.…”

“…Higher doses of procaine penicillin (i.e. 4-8 mega units) have been used for single session treatment in the USA (Lucas, Price, Thayer, and Schroeter, 1967;Shapiro and Lentz, 1967), but unless this preparation can be further concentrated a dose of this size probably represents the limit of the amount that can be given in a single injection (Shapiro and Lentz, 1967) if it does not exceed it (Holmes and others, 1967a); even so 14 per cent. of failures have been obtained with this technique.…”

“…More recently cure rates of 90-98-4 per cent. have been reported with one injection plus 1 g. orally at a single session Lentz, 1963, 1965;Prince, Randall, Lentz, and Shapiro, 1964), or with injection plus multiple oral doses (Berry, 1967) Other preparations are being tried in this way Has been little used for gonorrhoea 95 per cent. cure rate reported with single injections of chloromycetin succinate ( Table V) Single injections of 1 g. inadequate (Piguet, 1961), but excellent results with 1 g. given daily for 2-3 days (Piguet, 1961(Piguet, , 1962Ziprkowski and others, 1961;Wilkinson and others, 1967 Cure rates above 95 per cent.…”