AIDS‐generated anxiety may occur in the general public, health staff, patients and high‐risk individuals. Anxieties associated with AIDS create confusion in the patient and chronic anxiety may generate a ‘pseudo‐AIDS’ condition, the somatic features of which may be misinterpreted as evidence of the disease. Furthermore, chronic anxiety itself may be immunosuppressive. Management requires multistage intervention involving: relaxation, cognitive techniques, peer‐group support, health education, ‘marital’ therapy, drug therapy and hospitalization. Educating patients is not enough; the general public must be continually reminded that this infection is no respector of gender or sexual orientation.