Good agreements between self and clinician-collected specimens for the detection of human papillomavirus in Brazilian patients

Campos, Karla Lopes Mandu de; Machado, Ana Paula; Almeida, Flávia Gatto de; Bonin, Camila Mareti; Prata, Thiago Theodoro Martins; Almeida, Larissa Zatorre; Padovani, Cacilda Tezelli Junqueira; Ferreira, Alda Maria Teixeira; Fernandes, Carlos Eurico dos Santos; Tozetti, Inês Aparecida

doi:10.1590/0074-0276130397

Cited by 10 publications

(6 citation statements)

References 25 publications

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“…Several studies have been conducted around Brazil. The prevalence rates range from 10·5% to 48·6% [19][20][21][22][23][24][25][26][27]. In this study, we detected a high prevalence of HPV infection in Southern Bahia (47·7%, 95% CI 40·8-54·7), which is similar to the prevalence reported in Rio de Janeiro [27], and higher when compared with other regions including Salvador, the Capital of Bahia State [23,28].…”

Section: Discussionsupporting

confidence: 78%

Clinical, laboratory and epidemiological aspects of HPV infection in a low-income population from South Bahia, Brazil

Gadelha

Dmv

et al. 2017

Epidemiol. Infect.

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The aim of this study was to determine the prevalence and risk factors for human papillomavirus (HPV) infection in the Southern region of the State of Bahia, evaluating the performance of alternative complementary methods for cervical lesion detection. Cervical samples from women who attended healthcare units were collected and diagnosed by visual inspection, cervical cytology and nested polymerase chain reaction (PCR). Moreover, hemi-nested PCR was performed to detect different HPV genotypes. The prevalence of HPV infection was 47·7%, with genotype 16 detected in most cases. Infection was associated with dyspareunia and bleeding (P < 0·001, odds ratio (OR) 5·6, 95% confidence interval (CI) 2·815-11·14) and hormonal contraceptive use (P = 0·007, OR 2·33, 95% CI 1·25-4·34). There was a positive correlation between positive PCR and positive visual inspection, cervical cytology and symptoms reported. Furthermore, visual inspection was twice as specific, and had a greater positive predictive value than cytology. We showed a high prevalence of HPV infection in Southern Bahia, with HPV 16 being the most common type, and visual inspection being most effective at detecting HPV lesions, corroborating the suggestion that it can be applied in routine gynecologic examinations for low-income populations.

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Section: Discussionsupporting

confidence: 78%

Clinical, laboratory and epidemiological aspects of HPV infection in a low-income population from South Bahia, Brazil

Gadelha

Dmv

et al. 2017

Epidemiol. Infect.

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“…We believe that this strategy could improve the poor screening programs developed in our country. Not only the HPV DNA detection rate in self-sampling has been reported to be in good agreement with physician-sampling, but also the self-sampling method seems better accepted among women [24, 25]. It could therefore enhance cervical cancer screening program coverage, a primary prevention strategy in countries with low resources [26].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the self-sampling for cervical cancer screening in Bolivia

et al. 2019

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BackgroundIncidence and mortality rates of cervical cancer in Bolivia are the highest in Latin America. Vaginal cell self-sampling can improve screening coverage. Information on common reasons for low screening coverage and preferences for future screening are essential to reduce cervical cancer incidence. We aimed to evaluate the knowledge about human papillomavirus (HPV) and cervical cancer of Bolivian women from urban, peri-urban and rural areas of Cochabamba and to determine their degree of acceptability and confidence towards vaginal HPV self-sampling. In addition, we assessed the impact of self-sampling on cervical cancer screening coverage in a selected peri-urban area.MethodsWe gathered information from women living in urban, peri-urban and rural areas of Cochabamba province in Bolivia using two different structured questionnaires. In Survey1, we collected information from 222 women about their knowledge on HPV and cervical cancer. In Survey 2, the acceptance and confidence towards vaginal HPV self-sampling compared to the physician-sampling was assessed in 221 women. A non-probabilistic stratified sampling by areas was carried out for the two questionnaires. In the third phase of the study, we determined the impact of HPV self-sampling collection on screening coverage in a peri-urban area of Cochabamba.ResultsBolivian women knew little or nothing about cervical cancer and HPV infection in all areas. They all found self-sampling collection easier to perform (86.9 to 93.2%) and more comfortable (79.4 to 83.3%) compared to physician sampling. Sampling accuracy to detect cervical cancer was probably higher in their point of view when it was taken by physician (35.1 to 63.5%). However in rural areas women preferred self-sampling. Accordingly, the campaign of vaginal HPV self-sampling in this peri-urban area increased screening coverage, reaching in three months the annual rate average.ConclusionsThe knowledge about cervical cancer and HPV infection is poor in Bolivia. Despite greater acceptance of the vaginal HPV self-sampling in all areas, women kept greater confidence in the screening performed by the gynecologist although HPV self-sampling improved coverage rate.Electronic supplementary materialThe online version of this article (10.1186/s12889-019-6401-5) contains supplementary material, which is available to authorized users.

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“…HPV-induced cell transformation is mediated by the viral E6 and E7 oncoproteins interfering with the cell cycle regulators of the host cells, starting at the basal cells layer and gradually extending to the full epithelial thickness [ 9 , 18 ]. Once the infection is well established, the HPV genome is present as extra-chromosomal elements (episomes) in the nucleus, and the viral genome load is increased up to 50–100 copies per cell, while remaining high in the infectious phase [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, self-collection of vaginal specimens for HPV testing could be useful particularly for women who live in regions with low-resource settings and restricted access to adequate health care, like in many regions of Brazil, thus increasing the acceptability and coverage of the screening program. However, HPV DNA testing is not yet a routine in Brazil, despite the fact that several studies in Brazilian population have demonstrated its potential usefulness in CC prevention [ 20 , 43 , 44 ].…”

Section: Introductionmentioning

confidence: 99%

Human papillomavirus (HPV) screening and cervical cancer burden. A Brazilian perspective

Lorenzi

Syrjänen

Longatto‐Filho

2015

Virol J

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This review tackles the issues related to disease burden caused by cervical cancer (CC) and its precursor (CIN) lesions in Brazil. A special focus is given to new technologies with potential to interfere with the development of CC by reducing the high-risk human papillomavirus (hr-HPV)-induced lesions that remain a major public health burden in all developing countries where organized screening programs do not exist. Globally, 85 % of all incident CC and 50 % of CC deaths occur in the developing countries. Unfortunately, most regions of Brazil still demonstrate high mortality rates, ranking CC as the second most common cancer among Brazilian women. Recently, CC screening programs have been tailored in the country to enable early detection of CC precursor lesions and thereby reduce cancer mortality. A combination of HPV testing with liquid-based cytology (LBC) seems to be a promising new approach in CC screening, with high expectation to offer an adequate control of CC burden in this country.

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Good agreements between self and clinician-collected specimens for the detection of human papillomavirus in Brazilian patients

Cited by 10 publications

References 25 publications

Clinical, laboratory and epidemiological aspects of HPV infection in a low-income population from South Bahia, Brazil

Clinical, laboratory and epidemiological aspects of HPV infection in a low-income population from South Bahia, Brazil

Evaluation of the self-sampling for cervical cancer screening in Bolivia

Human papillomavirus (HPV) screening and cervical cancer burden. A Brazilian perspective

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