Good clinical practice advice: Iron deficiency anemia in pregnancy

Renzo, Gian Carlo Di; Fonseca, Eduardo Borges da; Gratacós, Eduard; Hassan, Sonia S.; Курцер, М. А.; Malone, Fergal D.; Nambiar, Shilpa; Nicolaides, Kypros; Sierra, Nancy; Yang, Huixia; Fuchtner, Carlos; Berghella, Vincenzo; Morales, Ernesto Castelazo; Hanson, Mark; Hod, Moshe; Ville, Y.; Visser, Gerard H.A.; Simpson, Joe Leigh; Adra, Abdallah; Bataeva, R.S.; Roura, Luis Cabero; Chmait, Ramen H.; Cheng, Yvonne W.; Hyett, Jon; Khalil, Asma; Malhotra, Narendra; Giardina, Irene; Morrison, John C.; Nazareth, Amala; Poon, Chiu Yee Liona; Purandare, C. N.; Quintero, Rubén A.; Sepúlveda, Waldo; Tosto, Valentina

doi:10.1002/ijgo.12740

Cited by 30 publications

(18 citation statements)

References 22 publications

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“…The human body, weighing 70 kg, contains 4 to 5 g of iron, approximately. However, iron deficiency has been reported to affect about two billion individuals, including a great number of pregnant women and young children [ 4 ]. It is also a major cause of anemia worldwide [ 5 ] and is one of the global issues for disability and even death [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

The Change in the Structure and Functionality of Ferritin during the Production of Pea Seed Milk

Xing

Yao

Chen

et al. 2022

Foods

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Understanding the effect of thermal treatment on the physical and chemical properties of protein and its mechanisms has important theoretical implications in food science. Pea seed ferritin (PSF) is an iron storage protein naturally occurring in pea seeds, which represents a promising iron supplement. However, how thermal processing affects the structure and function of PSF remains unknown. In this work, during the production of pea seed milk, we investigated the effect of thermal treatments at boiling temperature for two different times (5 and 10 min), respectively, on the structure and function of PSF. The results demonstrated that thermal treatment resulted in a pronounced change in the primary, secondary, and tertiary structure, iron content, and iron oxidation activity of PSF. However, the shell-like structure of PSF can be kept during the processing of pea seed milk. Interestingly, upon thermal treatment, both thermal-treated samples exhibit larger higher iron absorption rate by Caco-2 than untreated PSF at the same protein concentration. Such an investigation provides a better understanding of the relationship between the structure and function of food protein, as affected by thermal treatment.

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Section: Introductionmentioning

confidence: 99%

The Change in the Structure and Functionality of Ferritin during the Production of Pea Seed Milk

Xing

Yao

Chen

et al. 2022

Foods

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“…During pregnancy, anaemia is common due to higher requirements of iron and the effect of haemodilution caused by an increase in plasma volume [ 4 ]. IDA during pregnancy has been reported to be associated with intra- and postpartum haemorrhage and transfusion need [ 5 ] and it is not just the mother who is affected by IDA but the new-born as well, as iron deficiency affects growth and organ functioning, the immune system is also altered, and neurodevelopmental impairments and predisposition to postnatal iron deficiency have been reported [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Applying reflective multicriteria decision analysis to understand the value of therapeutic alternatives in the management of gestational and peripartum anaemia in Spain

Casellas

Hidalgo

García-Erce

et al. 2022

BMC Pregnancy Childbirth

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Background The objective of the FeminFER project was to assess the value of ferric carboxymaltose following a multicriteria decision analysis in obstetrics and gynaecology in Spain. Methods Ferric carboxymaltose (FCM) and ferrous sulphate were evaluated using the EVIDEM framework. Ten stakeholders participated to collect different perspectives. The framework was adapted considering evidence retrieved with a PICO-S search strategy and grey literature. Criteria/subcriteria were weighted by level of relevance and an evidence-based decision-making exercise was developed in each criterion; weights and scores were combined to obtain the value of intervention relative to each criterion/subcriterion, that were further combined into the Modulated Relative Benefit-Risk Balance (MRBRB). Results The most important criterion favouring FCM was Compared Efficacy/Effectiveness (0.183 ± 0.07), followed by Patient Preferences (0.059 ± 0.10). Only Direct medical costs criterion favoured FS (-0.003 ± 0.03). MRBRB favoured FCM; 0.45 ± 0.19; in a scale from -1 to + 1. Conclusions In conclusion, considering the several criteria involved in the decision-making process, participants agreed with the use of FCM according to its MRBRB.

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“…8,9 Conventionally, iron supplementation, either oral or parenteral, is recommended for the correction and treatment of IDA and iron stores. 10 Nearly 70% of women report gastrointestinal (GI) intolerance (nausea, constipation, diarrhea, indigestion, and metallic taste) with oral iron that affects compliance. 11 Thus, intravenous (IV) iron formulations such as iron sucrose and FCM may be preferred which can be administered from the second trimester onward.…”

Section: Introductionmentioning

confidence: 99%

Ferric Carboxymaltose for the Treatment of Anemia during Antenatal and Postpartum Period: Expert Opinion

Malhotra¹,

Malhotra²,

Gupte³

et al. 2022

Journal of South Asian Federation of Obstetrics and Gynaecology

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Iron therapy is a cornerstone for treating iron-deficiency anemia (IDA) in pregnancy and in the postpartum period. Oral iron is the first choice of iron preparation around the globe. However, intolerating gastrointestinal side effects with oral iron seriously affect the compliance. Intravenous (IV) iron, such as ferric carboxymaltose (FCM) is a useful alternative to oral iron for treatment of IDA. Use of FCM in the second and third trimesters of pregnancy and in postpartum anemia (PPA) is associated with a significant rise in hemoglobin (Hb) and replenishment of iron stores. With increasing use of FCM in IDA of pregnancy and PPA, there is a need for a unified approach. With this context, nearly 250 experts from the field of obstetrics and gynecology (ObGy) discussed the current evidence and their experiences with FCM use. After a series of expert meetings on an online platform, key opinions were formulated for the use of FCM in management of IDA in these subgroups. This paper brings out current evidence along with expert opinions for the use of FCM in the management of IDA in pregnancy and postpartum periods.

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Good clinical practice advice: Iron deficiency anemia in pregnancy

Cited by 30 publications

References 22 publications

The Change in the Structure and Functionality of Ferritin during the Production of Pea Seed Milk

The Change in the Structure and Functionality of Ferritin during the Production of Pea Seed Milk

Applying reflective multicriteria decision analysis to understand the value of therapeutic alternatives in the management of gestational and peripartum anaemia in Spain

Ferric Carboxymaltose for the Treatment of Anemia during Antenatal and Postpartum Period: Expert Opinion

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