Good correlation between the Afinion AS100 analyser and the ABX Pentra 400 analyser for the measurement of glycosylated haemoglobin and lipid levels in older adults in Durban, South Africa

Abbai, Nathlee; Nyirenda, Makandwe; Reddy, Tarylee; Ramjee, Gita

doi:10.7196/samj.2017.v108i1.12548

Cited by 18 publications

(18 citation statements)

References 15 publications

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“…[5] In both these studies, no follow-up of patients was performed to assess the effects of POCT on diabetes control at a later stage. [5,15] Our study showed good correlation between the Quo-Test POCT HbA1c values and NHLS laboratory values. Pillay et al [1] showed that the majority of patients with diabetes are diagnosed and have their therapy initiated at their local healthcare clinic.…”

Section: Discussionmentioning

confidence: 52%

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Validation and effect on diabetes control of glycated haemoglobin (HbA1c) point-of-care testing

et al. 2019

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Background. Optimal control of diabetes mellitus (DM) remains daunting globally. Point-of-care testing (POCT) for glycated haemoglobin (HbA1c) enables the clinician to make immediate management decisions and thereby improve DM control and complications. Better control is increasingly being striven for in developing countries where availability of POCT devices is limited. Methods. Every alternate patient who visited the diabetes clinic at Edendale Hospital, Durban, South Africa, between 1 June 2017 and 31 August 2017 was invited to participate in the study. These patients made up the POCT group, with the remainder making up the control laboratory group. The POCT group had Quo-Test HbA1c POCT done at the clinic visit and their treatment was adjusted based on the HbA1c reading, while the control group received standard treatment. The two groups of patients were reviewed at 3 months to identify differences in diabetes control between them. Results. Data from 266 patients were analysed (135 in the POCT group v. 131 in the control group). There was no significant difference between the price of the POCT and laboratory HbA1c tests (p=0.823). The POCT and laboratory HbA1c values showed good correlation at baseline (r=0.995; p<0.001). The two groups of patients were evenly matched in respect of most demographic and clinical variables. Patients in the POCT group showed a significant improvement in mean (standard deviation) glycaemic control between baseline and 3 months (9.61 (2.46) v. 8.98 (2.15); p<0.043). No improvement was noted in the control group (9.58 (2.49) v. 9.43 (2.15); p=0.823). Conclusions. The Quo-Test HbA1c POCT had good correlation with standard laboratory methods in respect of both glycaemic control and price. Patients who had POCT at baseline showed a significant improvement in glycaemic control at 3 months. HbA1c POCT in the setting of a multifaceted approach to diabetes care has been shown to have definite benefits.

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Section: Discussionmentioning

confidence: 52%

“…Recently, Abbai et al [15] demonstrated in their study in Durban, SA, that there was good correlation between POCT and laboratory HbA1c values using the Afinion AS100 point-of-care analyser. This study, however, only included patients aged >50 years (mean 66 years).…”

Section: Discussionmentioning

confidence: 98%

Validation and effect on diabetes control of glycated haemoglobin (HbA1c) point-of-care testing

et al. 2019

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“…One drop of blood will be taken up by the test strip and read by the machine. Good correspondence exists between the Alere point-of-care (PAC) analyser results and reference laboratory tests for HbA1c and lipid levels [171, 172]. Following Rodondi et al [173], the following clinically relevant cut-off values should be considered for total cholesterol (≥ 5.6 mmol/l), HDL-C (≤ 1.41 mmol/l), and LDL-C (≥ 3.40 mmol/l).…”

Section: Methodsmentioning

confidence: 99%

The impact of lifestyle Physical Activity Counselling in IN-PATients with major depressive disorders on physical activity, cardiorespiratory fitness, depression, and cardiovascular health risk markers: study protocol for a randomized controlled trial

Gerber

Beck

Brand

et al. 2019

Trials

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Background Major depressive disorder (MDD) is a widespread and burdensome psychiatric issue. Physical activity counselling may increase lifestyle physical activity and cardiorespiratory fitness in this specific and particularly vulnerable population, which often suffers from both mental and physical health problems. Therefore, this study will examine the impact of a lifestyle physical activity counselling intervention on physical activity, cardiorespiratory fitness, depression, and cardiovascular health risk markers among in-patients diagnosed with MDD compared to controls. Secondary purposes are to examine the acceptability and perceived usefulness of the intervention among these patients, to find out whether the effectiveness of the intervention is moderated by genetic factors, and to compare baseline values with an age- and gender-matched group of healthy controls. Methods The study is designed as a multi-centric two-arm randomized clinical trial including an intervention group and a placebo control group, allocation concealment, single-blinding, and intention-to-treat analysis. Participants ( N = 334) will be continuously recruited from four clinics specialized in the treatment of MDD. The intervention builds on a standardized, theory-based, low-cost lifestyle physical activity counselling programme, which was specifically designed for an in-patient rehabilitation setting. The placebo control condition consists of general instructions about health-enhancing physical activity. Data assessments will take place 2–3 weeks after admission to in-patient treatment (baseline), and 6 weeks (post) and 12 months (follow-up) after discharge from in-patient treatment. The primary outcome is objectively assessed physical activity at follow-up. Discussion Because regular physical activity has proven to be an important predictor of long-term response and remission in patients with major depression, we believe that our planned study may lay important groundwork by showing how individually tailored lifestyle physical activity counselling can be integrated into given clinical structures. Improving physical activity may have important implications for tackling metabolic and cardiovascular disease and increasing mood and cognitive functioning in this at-risk population, hence limiting the future burden of multiple chronic conditions. Increased physical activity may also reduce the likelihood of future depressive episodes. By moving towards the primary prevention of chronic physical conditions, much can be done to enhance the quality and quantity of life of people with MDD. Trial registration ISRCTN, ISRCTN10469580 . Registered on 3 September 2018. Electronic supplementary material The online version of this article (10.1186/s13063-019-3468-3) contains supplementary material, which is available to authorized users.

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“…Fourthly, precision studies: precision performance forms the cornerstone for the assessment of clinical utility of a test or an instrument. Abbai et al [1] have not presented data with regard to imprecision performance of the POC analyser for the tests evaluated. Shephard et al [5] have proposed desirable imprecision goals for POC devices for HbA1c (coefficient of variation 3%) and lipid parameters.…”

mentioning

confidence: 99%

“…The American Diabetes Association also provide recommendations for HbA1c precision. Abbai et al [1] only evaluated performance of Afinion HbA1c with regard to correct categorisation of patients at one medical decision point (HbA1c 6.5%). As one of the primary roles of POC testing (POCT) is the monitoring of diabetic patients receiving treatment in order to allow for a more prompt change in management, evaluation at other important medical decision limits, e.g.…”

mentioning

confidence: 99%

Considerations regarding point-of-care testing

Gounden

2018

S Afr Med J

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Good correlation between the Afinion AS100 analyser and the ABX Pentra 400 analyser for the measurement of glycosylated haemoglobin and lipid levels in older adults in Durban, South Africa

Abstract: This study supports the use of the Afinion AS100 analyser in POC testing for the measurement of HbA1c, triglycerides and HDL-C in a South African setting.

Cited by 18 publications

References 15 publications

Validation and effect on diabetes control of glycated haemoglobin (HbA1c) point-of-care testing

Validation and effect on diabetes control of glycated haemoglobin (HbA1c) point-of-care testing

The impact of lifestyle Physical Activity Counselling in IN-PATients with major depressive disorders on physical activity, cardiorespiratory fitness, depression, and cardiovascular health risk markers: study protocol for a randomized controlled trial

Considerations regarding point-of-care testing

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