Good longterm survival after primary living donor liver transplantation for solitary hepatocellular carcinomas up to 8cm in diameter

Abstract

Living donor liver transplantation surpassed LR in survival outcomes, achieving a 10-year overall survival rate 1.5 times as high and a 10-year disease-free survival rate twice as high as those facilitated by LR. However, it entailed more complications, in addition to the inevitable risks to the donor.

Impact of intraoperative blood transfusion on long‐term outcomes of liver transplantation for hepatocellular carcinoma

“…Similar findings have also been made with malignancies of the breast, the stomach, and the colon and rectum . It is speculated that perioperative blood transfusions cause immunomodulation reactions and thus have a deleterious effect on the recurrence of malignancies and the survival of patients, which was demonstrated in recent studies …”

“…The strategies adopted for selection of patients with known HCC for transplantation have been described elsewhere . In brief, tumour evaluation was done with computed tomography of the abdomen and thorax, in addition to radionuclide bone scan at initial diagnosis.…”

Radiofrequency ablation versus transarterial chemoembolization for unresectable solitary hepatocellular carcinomas sized 5–8 cm

“…A recent study reported that patients who underwent hepatectomy or living‐donor liver transplantation as a primary treatment for solitary HCC sized 5–8 cm achieved 5‐year overall survival rates of 68.9% and 87.5%, respectively . A comparison of the relative efficacy of TACE and RFA in treating patients with unresectable HCCs of ≥5 cm is lacking in the literature.…”

Living Donor Liver Transplantation for Hepatocellular Carcinoma

“…However, even in many Asian centers which perform LDLT on regular basis, up to 50% of early HCC cases may not have suitable donors or be concerned about the risk to donor. So, many Asian centers adopt the policy of offering LR to patients with resectable tumors with compensated cirrhosis and deferring LT to the salvage setting [13,23,77,78].…”

“…So, the choice of primary LT is recommended. The same approach is adopted by the American Association of Study of Liver Disease (AASLD) guidelines that prefer liver resection for very early cases with the optimal liver profile [7,78,81,82].…”