Good old-fashioned (anti)sense

Golden, Susan S.

doi:10.1073/pnas.0601872103

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…2C) is beneficial to the cellular energy budget. First, isiA becomes the most abundant transcript in cells subjected to oxidative stress (17). Second, IsiA expression saves photosynthesis in stressed cells, but decreases photosynthesis efficiency and thus energy production in non-stressed cells (16).…”

Section: Pulse Filtering Properties Of Srna Circuitsmentioning

confidence: 99%

Small RNAs Establish Delays and Temporal Thresholds in Gene Expression

Legewie

Dienst

Wilde

et al. 2008

Biophysical Journal

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Noncoding RNAs are crucial regulators of gene expression in prokaryotes and eukaryotes, but how they affect the dynamics of transcriptional networks remains poorly understood. We analyzed the temporal characteristics of the cyanobacterial iron stress response by mathematical modeling and quantitative experimental analyses and focused on the role of a recently discovered small noncoding RNA, IsrR. We found that IsrR is responsible for a pronounced delay in the accumulation of isiA mRNA encoding the late-phase stress protein, IsiA, and that it ensures a rapid decline in isiA levels once external stress triggers are removed. These kinetic properties allow the system to selectively respond to sustained (as opposed to transient) stimuli and thus establish a temporal threshold, which prevents energetically costly IsiA accumulation under short-term stress conditions. Biological information is frequently encoded in the quantitative aspects of intracellular signals (e.g., amplitude and duration). Our simulations reveal that competitive inhibition and regulated degradation allow intracellular regulatory networks to efficiently discriminate between transient and sustained inputs.

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Section: Pulse Filtering Properties Of Srna Circuitsmentioning

confidence: 99%