Good outcome in early pregnancy following direct thrombolysis for cerebral venous sinus thrombosis

Weatherby, S. J. M.; Edwards, Nathaniel; West, R.; Heafield, M. T. E.

doi:10.1007/s00415-003-0173-6

Cited by 30 publications

(13 citation statements)

References 7 publications

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“…103 Combined intrathrombus r-tPA and IV heparin with good outcomes has also been reported. 104,105 Mortality from pregnancy-associate CST is 10% to 50%, 99 with case-fatality rate in the range of 4% to 36%. 106 …”

Section: Cerebral Sinus Thrombosismentioning

confidence: 99%

Neurologic Complications in Pregnancy

Cuero

Varelas

2016

Critical Care Clinics

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Section: Cerebral Sinus Thrombosismentioning

confidence: 99%

Neurologic Complications in Pregnancy

Cuero

Varelas

2016

Critical Care Clinics

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“…Including Non-stroke Therapy 46) ), 7 with thrombosed valve, 16,32,33) 7 with pulmonary embolism, 2,5, 17,35,42,51) 3 with deep vein thrombosis, 6) and 1 with acute myocardial infarction. 39) Maternal outcomes were good for 23 of these patients, 2 died (7%), and 3 experienced hemorrhagic complications (10.7%).…”

Section: Reports Of Rt-pa Use During Pregnancymentioning

confidence: 99%

Acute Revascularization Therapy in Pregnant Patients

Hirano

2013

Neurol. Med. Chir.(Tokyo)

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Ischemic stroke is uncommon during pregnancy, but decision making for acute revascularization therapy including intravenous recombinant tissue plasminogen activator (rt-PA) is difficult. The use of rt-PA remains controversial, but a systematic review of 16 patients (mean age 31.7 years) showed good results for both maternal (77.8%) and fetal (56.3%) outcomes. Pregnancy alone is not a solid contraindication for acute revascularization therapy including rt-PA. An endovascular approach might be beneficial for reducing the hemorrhagic complication; however, the treatment strategy should be considered based on the available treatment facility. Close cooperation with obstetrics is essential for the successful management of saving the lives of both the mother and the fetus.

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“…In some cases, thrombolytic agents have been given during the first trimester, sometimes inadvertently. In a few pregnant women with cerebral venous thrombosis, direct thrombolysis has been successfully used 112,115 . Teratogenicity has not been reported, but the risk of maternal hemorrhage is high.…”

Section: Special Considerations: Stroke In the Pregnant Patientmentioning

confidence: 99%

“…In a few pregnant women with cerebral venous thrombosis, direct thrombolysis has been successfully used. 112,115 Teratogenicity has not been reported, but the risk of maternal hemorrhage is high. In a review of off-label thrombolysis for acute ischemic stroke, symp-tomatic intracranial hemorrhage occurred in one of 11 pregnant women.…”

Section: Thrombolysismentioning

confidence: 99%

Stroke Treatment

Cronin¹,

Weisman

Llinás³

2008

Annals of the New York Academy of Sciences

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For acute stroke patients who arrive at the hospital within 3 h of symptom onset, the focus of care involves screening for eligibility to receive intravenous tissue plasminogen activator. The publication of the National Institute of Neurological Disorders and Stroke recombinant tissue-type plasminogen activator (tPA, or alteplase) study in 1995 (Marler, J.R. 1995, New England Journal of Medicine333: 1581-1587) spurred protocol changes, which continue to evolve, throughout the health care system in an effort to streamline the patient through the Emergency Medical System. The need to expedite patient evaluation involving emergency department, laboratory, radiology, and clinical neurology testing is clear and has been a focus of many stroke centers. For some patients, intravenous thrombolysis within 3 h has a dramatic effect on outcome. However, that is not the only course of action for acute stroke patients. This article will review some of the effective treatments for stroke patients beyond the first 3 h of their care.

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Good outcome in early pregnancy following direct thrombolysis for cerebral venous sinus thrombosis

Cited by 30 publications

References 7 publications

Neurologic Complications in Pregnancy

Neurologic Complications in Pregnancy

Acute Revascularization Therapy in Pregnant Patients

Stroke Treatment

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