Good relationship between saliva cotinine kinetics and plasma cotinine kinetics after smoking one cigarette

Yuki, Dai; Kikuchi, Akira; Miura, Naoki; Kakehi, Aoi; Onozawa, Masahiro

doi:10.1016/j.yrtph.2013.08.002

Cited by 15 publications

(8 citation statements)

References 17 publications

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“…This design choice was intended to explore the use of noninvasive and potentially more sensitive measure of nicotine exposure. To the authors’ knowledge, saliva nicotine has been used in only three published acute exposure studies each involving cigarette smoking (Corrigall et al, 2001; Schramm et al, 1992; Yuki et al, 2013) and an examination of the relationship between saliva and plasma nicotine among nicotine patch users (Rose et al, 1993). This prior work supports the idea saliva nicotine increases following tobacco smoke exposure (Corrigall et al, 2001; Schramm et al, 1992; Yuki et al, 2013), and plasma and saliva nicotine concentrations may be correlated highly ( r = 0.82; Rose et al, 1993).…”

Section: Discussionmentioning

confidence: 99%

“…To the authors’ knowledge, saliva nicotine has been used in only three published acute exposure studies each involving cigarette smoking (Corrigall et al, 2001; Schramm et al, 1992; Yuki et al, 2013) and an examination of the relationship between saliva and plasma nicotine among nicotine patch users (Rose et al, 1993). This prior work supports the idea saliva nicotine increases following tobacco smoke exposure (Corrigall et al, 2001; Schramm et al, 1992; Yuki et al, 2013), and plasma and saliva nicotine concentrations may be correlated highly ( r = 0.82; Rose et al, 1993). Mean saliva nicotine concentrations observed here (between 190.4 and 952.5 ng/ml) were comparable to those measured in a prior acute settings involving cigarette smokers (Schramm et al, 1992; Yuki et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

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Acute effects of flavored Black and mild cigars among young adult cigarette smokers.

Maldonado¹,

Bono²,

Wall³

et al. 2023

Experimental and Clinical Psychopharmacology

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The U.S. Food and Drug Administration proposed new product standards that would ban characterizing flavors (other than tobacco) in cigars. To inform this regulatory action, we compared physiological effects, use behavior, and subjective effects of four popular cigar flavors in cigar-naïve young adult cigarette smokers. Across five laboratory visits, participants (n = 25) used and evaluated own brand (OB) cigarettes or Black & Mild cigars (original, wine, apple, and cream flavors). Linear mixed models tested differences in saliva nicotine, exhaled carbon monoxide (CO), heart rate (HR), blood pressure (BP), puff topography, and subjective effects (p < .05). Compared to all cigars, OB resulted in higher nicotine boost (953 vs. <300 ng/ml) and lower CO boost (4 vs. 8–9 ppm). Nicotine boost for original cigars (283 ng/ml) was significantly higher than wine (190 ng/ml). All products significantly increased HR/BP relative to baseline, but across time wine and apple cigars were associated with significantly lower HR than OB and BP effects varied. Relative to OB, participants took approximately 0.5 s longer puffs for all cigars and took significantly larger puffs (+21%–24%) of original, wine, and apple cigars. OB was rated more positively than all cigars, which had similar subjective effects. Wine cigars were disliked most and were less effective in reducing tobacco abstinence symptoms than OB; cream cigars were harsher and had stronger flavor intensity than original. The consistency in toxicant exposure, use behavior, and subjective effects across cigar flavors, including original, highlights the need for product standards to interpret characterizing flavors subject to prohibition broadly.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Acute effects of flavored Black and mild cigars among young adult cigarette smokers.

Maldonado¹,

Bono²,

Wall³

et al. 2023

Experimental and Clinical Psychopharmacology

View full text Add to dashboard Cite

show abstract

“…Thus, there is a need for noninvasive biofluids that are ethically appropriate, cost-efficient, and toxicologically rele-vant [20][21][22]. Studies have demonstrated that the pharmacokinetics in saliva are well correlated with that in plasma [23]. Due to advantages such as noninvasiveness and easy sample collection, saliva is an important body fluid suited to study the pharmacokinetics in humans.…”

Section: Abbreviationsmentioning

confidence: 99%

Establishment of an Enzyme-Linked Immunosorbent Assay and Application on Determination of Ginsenoside Re in Human Saliva

Sai

Yan

et al. 2014

Planta Med

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This work describes an immunochemical approach for the quality control of Panax ginseng and a pharmacological study of ginsenoside Re, a major bioactive constituent in P. ginseng, using an enzyme-linked immunosorbent assay. A hybridoma secreting monoclonal antibody against ginsenoside Re was produced by fusing splenocytes immunized with a ginsenoside Re-bovine serum albumin conjugate with the hypoxanthine-aminopterin-thymidine-sensitive mouse myeloma SP2/0 cell line. The method, at an effective measuring range of 7.8-500 ng · mL(-1) of ginsenoside Re, successfully detected ginsenoside Re in Chinese traditional herb prescriptions. The results demonstrate that we generated a novel and reliable assay system for measuring ginsenoside Re in Chinese medicines more efficiently. Futhermore, we determined the ginsenoside Re concentrations in the saliva of six healthy adults after the oral administration of a ginseng capsule to study the pharmacokinetics of ginsenoside Re in human saliva.

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“…In addition, saliva is a suitable surrogate diagnostic tool for other body fluids as saliva testing is cost-effective, simple and non-invasive [19]. In individuals, salivary cotinine concentrations have been shown to be approximately the same as plasma concentrations [20]. Until now, only few studies aimed to focus on the determinants of SHS exposure, although this information is needed for adequate public health policies to protect non-smokers.…”

Section: Introductionmentioning

confidence: 99%

Factors associated with secondhand smoke exposure among non-smoking employees in the workplace: A cross-sectional study in Qingdao, China

Jia

Wang

et al. 2022

Preprint

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Objective The study was designed to describe secondhand smoke (SHS) exposure among non-smoking employees in the workplace and identify factors that related exposure in Qingdao. Methods The study subjects covered the key non-smoking places stipulated in the “Qingdao City Smoking Control Regulations”. Airborne nicotine concentration in the workplace and saliva cotinine concentration of employees were measured. Questionnaire included employees’ demographics factors, smoke-free measures in the workplace, the employer’s tobacco hazard knowledge and attitudes towards smoke-free policy. Results A total of 222 non-smoking employees and 46 employees were included in the study. The median concentrations of airborne nicotine and salivary cotinine were 0.389 µg/m 3 and 0.575 ng/ml. Educational status, average number of smokers per day and exposure time of SHS in the workplace, whether to divide smoking and non-smoking areas were related to the airborne nicotine concentration significantly. Age, educational status, exposure time of SHS in the workplace, tobacco control training and publicity and whether the employers support the “Qingdao Tobacco Control Regulation” were related to the salivary cotinine concentration significantly. Conclusions : Exposure to SHS is highly prevalent among non-smoking employees in the workplace. Interventions to reduce SHS exposure in the workplace are urgently needed.

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Good relationship between saliva cotinine kinetics and plasma cotinine kinetics after smoking one cigarette

Cited by 15 publications

References 17 publications

Acute effects of flavored Black and mild cigars among young adult cigarette smokers.

Acute effects of flavored Black and mild cigars among young adult cigarette smokers.

Establishment of an Enzyme-Linked Immunosorbent Assay and Application on Determination of Ginsenoside Re in Human Saliva

Factors associated with secondhand smoke exposure among non-smoking employees in the workplace: A cross-sectional study in Qingdao, China

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