Good response to HBsAg vaccine in dialysis patients is associated with high CD4+/CD8+ ratio

Sarı, Funda; Taşkapan, Hülya

doi:10.1007/s11255-011-0043-6

Cited by 15 publications

(9 citation statements)

References 22 publications

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“…What’s more, a positive correlation was observed between the SI and IgG level, indicating that both quantity and function of T cells are associated with immunological effect of HBV vaccine. Previous studies have shown that good antibody response to HBV vaccine is associated with higher CD4 + T cell counts [29], [30] or high CD4 + /CD8 + ratio [31]. Moreover, zinc is required for the regeneration of CD4 + T cells [32], [33], and zinc deficiency is associated with significantly decreased CD4 + /CD8 + ratio and lowered B cell numbers [34], which is similar to our findings.…”

Section: Discussionsupporting

confidence: 90%

Gestational Zinc Deficiency Impairs Humoral and Cellular Immune Responses to Hepatitis B Vaccination in Offspring Mice

et al. 2013

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BackgroundGestational zinc deficiency has been confirmed to impair the infant immune function. However, knowledge about effects of maternal mild zinc deficiency during pregnancy on hepatitis B vaccine responsiveness in offspring is limited. In this report, we aimed to examine how maternal zinc deficiency during pregnancy influences humoral and cellular immune responses to hepatitis B vaccination in offspring of BALB/c mice.Methodology/Principal FindingsFrom day 1 of pregnancy upon delivery, maternal mice were given a standard diet (30 mg/kg/day zinc), zinc deficient diet (8 mg/kg/day zinc), or combination of zinc deficient diet (8 mg/kg/day zinc in the first 2 weeks of gestation) and zinc supplement diet (150 mg/kg/day zinc for the last week of pregnancy), respectively. Newborn pups of these maternal mice were immunized with hepatitis B vaccine at postnatal weeks 0, 2 and 4. Then, splenocytes and blood samples from the offspring mice were harvested for detection of serum zinc concentrations, humoral and cell-mediated immune responses, expression of cytokines using ELISA, CCK-8 and flow cytometric analysis. Results from the present study demonstrated that gestational zinc deficiency inhibited antibody responses, and decreased the proliferative capacity of T cells in offsprings immunized with hepatitis B vaccine. Additionally, HBsAg-specific cytokines analysis revealed that gestational zinc deficiency could inhibit secretion of IFN-γ from splenocytes, and decrease IFN-γ expression of CD4+ and CD8+ T cells.Conclusions/SignificanceGestational zinc deficiency can weaken the humoral and cell-mediated immune responses to hepatitis B vaccine via decreasing B cell counts and hepatitis B virus-specific immunoglobulin G production, as well as reducing T cell proliferation, CD4+/CD8+ T cell ratio, and Th1-type immune responses.

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Section: Discussionsupporting

confidence: 90%

Gestational Zinc Deficiency Impairs Humoral and Cellular Immune Responses to Hepatitis B Vaccination in Offspring Mice

et al. 2013

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“…However, there was significant heterogeneity of the studies included in the meta‐analysis; this limitation was acknowledged by the authors. A few small trials in the Asian population found a similar association with age, whereas conflicting results were noted in some others . Additionally, Lin and colleagues reported that nonresponse to the vaccine was associated with infection‐cause mortality in ESRD patients, although there was no impact of the immune response on the 5‐year survival rate.…”

Section: Hepatitis Bmentioning

confidence: 99%

“…A growing body of literature has recognized a number of other factors relating to the efficacy of the hepatitis vaccine in patients with kidney disease. Immune deficiency in the uremic milieu, malnutrition , male gender , hepatitis C virus infection , and diabetes mellitus have been associated with a diminished vaccine response albeit some studies refute these associations . Some previous studies have demonstrated that seroconversion rates correlate with the stage of CKD , substantiating the recommendation for vaccinating patients with CKD before they become dialysis dependent .…”

Section: Hepatitis Bmentioning

confidence: 99%

Immunization in End‐Stage Renal Disease: Opportunity to Improve Outcomes

Soni

Horowitz

Unruh

2013

Seminars in Dialysis

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Infection is the second most common cause of death in patients with end-stage renal disease (ESRD), following cardiovascular causes. Immunization is a fairly simple, but underutilized, strategy for prevention of infectious morbidity and mortality in patients with kidney failure. It is imperative for nephrologists and primary care providers to have an understanding of immunization as an essential component of preventive healthcare measures in this high-risk population. Patients with ESRD represent a unique population due to their immunosuppressed state, dialysis-related exposures and suboptimal response to routine vaccines. While the Advisory Committee on Immunization Practices (ACIP) provides guidelines for vaccination of patients with renal disease against Hepatitis B, influenza and pneumococcal disease, the data on immunization against other commonly preventable infectious diseases are lacking. This article reviews the recent evidence on immunization in the ESRD population and synthesizes the related implications for maximizing prevention of infectious diseases in this high-risk population.

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“…In HD patients, the activity of NK cells is either lowered or unchanged [17]. A higher CD4/CD8 ratio, a marker of Ig production by B cells, is also associated with a better serological response to hepatitis B vaccination [18].…”

Section: Effects On Immune Responsementioning

confidence: 99%

Effects of L-carnitine supplementation on nutritional, immunological, and cardiac parameters in hemodialysis patients: a pilot study

et al. 2015

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Background: L-carnitine is an essential compound that facilitates the transport of long-chain fatty acid across the inner mitochondrial membrane for β-oxidation. However, the effect of L-carnitine supplementation remains to be fully explored in patients with chronic kidney disease. We aimed in this study to determine the multidirectional effects of L-carnitine supplementation on clinical parameters in more detail. Methods: We orally administered L-carnitine to maintain serum-free carnitine levels within the normal range (30 to 70 μmol/L) for 6 months in 21 hemodialysis (HD) patients (age, 74 ± 11 years; time on HD, 60 ± 84 months).

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Good response to HBsAg vaccine in dialysis patients is associated with high CD4+/CD8+ ratio

Abstract: High skin test anergy rate and low seroconversion rate after hepatitis B vaccination are important problems in patients on dialysis. Females, younger patients, and patients with higher CD4+/CD8+ ratio have better HBsAb antibody response to hepatitis B vaccination.

Cited by 15 publications

References 22 publications

Gestational Zinc Deficiency Impairs Humoral and Cellular Immune Responses to Hepatitis B Vaccination in Offspring Mice

Gestational Zinc Deficiency Impairs Humoral and Cellular Immune Responses to Hepatitis B Vaccination in Offspring Mice

Immunization in End‐Stage Renal Disease: Opportunity to Improve Outcomes

Effects of L-carnitine supplementation on nutritional, immunological, and cardiac parameters in hemodialysis patients: a pilot study

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