Goose IFIT5 positively regulates goose astrovirus replication in GEF cells

Li, Ruixue; Zhai, Saimin; Gao, Shenyan; Yang, Xia; Zhao, Jun; Zhang, Xiaozhan; Wang, Zeng

doi:10.1016/j.psj.2024.103930

Poultry Science

2024

DOI: 10.1016/j.psj.2024.103930

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Goose IFIT5 positively regulates goose astrovirus replication in GEF cells

Ruixue Li,

Saimin Zhai,

Shenyan Gao

et al.

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Antiviral Effects of Avian Interferon-Stimulated Genes

He,

Zhang,

Zou

et al. 2024

Animals

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Interferons (IFNs) stimulate the expression of numerous IFN-stimulating genes via the Janus kinase-signal transducers and activators of the transcription (JAK-STAT) signaling pathway, which plays an important role in the host defense against viral infections. In mammals, including humans and mice, a substantial number of IFN-stimulated genes (ISGs) have been identified, and their molecular mechanisms have been elucidated. It is important to note that avian species are phylogenetically distant from mammals, resulting in distinct IFN-induced ISGs that may have different functions. At present, only a limited number of avian ISGs have been identified. In this review, we summarized the identified avian ISGs and their antiviral activities. As gene-editing technology is widely used in avian breeding, the identification of avian ISGs and the elucidation of their molecular mechanism may provide important support for the breeding of avians for disease resistance.

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Antiviral Effects of Avian Interferon-Stimulated Genes

He,

Zhang,

Zou

et al. 2024

Animals

View full text Add to dashboard Cite

show abstract

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Goose IFIT5 positively regulates goose astrovirus replication in GEF cells

Cited by 1 publication

References 48 publications

Antiviral Effects of Avian Interferon-Stimulated Genes

Antiviral Effects of Avian Interferon-Stimulated Genes

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